David E. Harrison

Overview

Best Publications

• Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

  David E. F. Harrison;Randy Strong;Zelton Dave Sharp;James F Nelson

  4019
  Citations

• Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

  Richard A. Miller;Richard A. Miller;David E. Harrison;C. M. Astle;Joseph A. Baur

  1013
  Citations

• Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

  Kevin Flurkey;John Papaconstantinou;Richard A. Miller;David E. Harrison

  911
  Citations

• Mouse models in aging research.

  Kevin Flurkey;Joanne M. Currer;D.E. Harrison

  815
  Citations

• Rapamycin slows aging in mice.

  John E. Wilkinson;Lisa Burmeister;Susan V. Brooks;Chi Chao Chan

  769
  Citations

• Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

  Richard A. Miller;David E. Harrison;Clinton M. Astle;Elizabeth Fernandez

  603
  Citations

• Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

  David E. Harrison;Randy Strong;David B. Allison;Bruce N. Ames

  480
  Citations

• Competitive repopulation: a new assay for long-term stem cell functional capacity.

  David E. Harrison

  474
  Citations

• Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels.

  Rong Yuan;Shirng-Wern Tsaih;Stefka B. Petkova;Caralina Marin De Evsikova

  446
  Citations

• Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

  David E. Harrison;Clinton M. Astle

  397
  Citations

• Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

  Randy Strong;Richard A Miller;Adam Antebi;Clinton M Astle

  380
  Citations

• Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.

  Randy Strong;Richard A. Miller;Richard A. Miller;Clinton M. Astle;Robert A. Floyd;Robert A. Floyd

  352
  Citations

• Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil.

  David E. Harrison;Charles P. Lerner

  338
  Citations

• Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

  D. E. Harrison;C. T. Jordan;Rui Kun Zhong;C. M. Astle

  338
  Citations

• 5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.

  C Lerner;D E Harrison

  334
  Citations

• Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains

  Lawrence C. Erway;James F. Willott;Jonathan R. Archer;David E. Harrison

  316
  Citations

• Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.

  D E Harrison;C M Astle;J A Delaittre

  309
  Citations

• Number and continuous proliferative pattern of transplanted primitive immunohematopoietic stem cells

  David E. Harrison;Clinton M. Astle;Charles Lerner

  289
  Citations

• The Snell dwarf mutation Pit1dw can increase life span in mice

  Kevin Flurkey;John Papaconstantinou;David E Harrison

  287
  Citations

• An Aging Interventions Testing Program: study design and interim report.

  Richard A. Miller;David E. Harrison;Clinton M. Astle;Robert A. Floyd

  262
  Citations