His primary scientific interests are in Oxidative stress, Molecular biology, Biochemistry, Reactive oxygen species and Endocrinology. His Oxidative stress research incorporates elements of Myocarditis, Submitochondrial particle, Mitochondrial respiratory chain, Gene chip analysis and Respiratory chain. His research in Molecular biology intersects with topics in Molecular cloning, Gene expression, Regulatory sequence and Gene isoform.
His Reactive oxygen species study combines topics from a wide range of disciplines, such as Enzyme activator, Superoxide dismutase and p38 mitogen-activated protein kinases. The concepts of his Endocrinology study are interwoven with issues in Internal medicine, Senescence and Signal transduction. His Internal medicine study combines topics in areas such as Fumarylacetoacetate hydrolase and Protein kinase B.
John Papaconstantinou mainly investigates Molecular biology, Internal medicine, Endocrinology, Oxidative stress and Gene expression. The study incorporates disciplines such as Gene isoform, Messenger RNA, Transcription and Transcription factor in addition to Molecular biology. In his study, which falls under the umbrella issue of Internal medicine, Molecular cloning and Escherichia coli is strongly linked to Mutant.
His work carried out in the field of Endocrinology brings together such families of science as Mitogen-activated protein kinase, Signal transduction, Senescence, Longevity and Stress Response Signaling. His Oxidative stress research incorporates themes from Reactive oxygen species and Mitochondrion. His studies deal with areas such as Transforming growth factor and Fatty acid metabolism as well as Gene expression.
The scientist’s investigation covers issues in Oxidative stress, Cell biology, Reactive oxygen species, Senescence and Internal medicine. His study in Oxidative stress is interdisciplinary in nature, drawing from both Molecular biology and Membrane. His studies in Molecular biology integrate themes in fields like Lipopolysaccharide and Cytokine.
His Cell biology study incorporates themes from Insulin receptor and Longevity. His Senescence study integrates concerns from other disciplines, such as Pregnancy, In vivo, DNA damage and MAPK/ERK pathway. His Internal medicine course of study focuses on Endocrinology and Stress Response Signaling and Cell type.
John Papaconstantinou mainly focuses on Oxidative stress, Cell biology, Reactive oxygen species, ASK1 and Klotho. Oxidative stress is a subfield of Biochemistry that John Papaconstantinou explores. His Cell biology research is multidisciplinary, incorporating elements of Amnion and Insulin.
His ASK1 research overlaps with other disciplines such as Kinase, p38 mitogen-activated protein kinases, Endocrinology and Internal medicine. His work in the fields of Thioredoxin overlaps with other areas such as MPTP and Pars compacta. The various areas that he examines in his Klotho study include Insulin receptor, Receptor, Hormone, Signal transduction and Longevity.
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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
Kevin Flurkey;John Papaconstantinou;Richard A. Miller;David E. Harrison.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.
Tawfiq Alam;Mi Ra An;John Papaconstantinou.
Journal of Biological Chemistry (1992)
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.
Markus Grompe;Sven Lindstedt;Muhsen Al-Dhalimy;Nancy G. Kennaway.
Nature Genetics (1995)
Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.
Paul L. DeAngelis;John Papaconstantinou;Paul H. Weigel.
Journal of Biological Chemistry (1993)
The Snell dwarf mutation Pit1dw can increase life span in mice
Kevin Flurkey;John Papaconstantinou;David E Harrison.
Mechanisms of Ageing and Development (2002)
Oxidatively damaged proteins of heart mitochondrial electron transport complexes.
K. B. Choksi;W. H. Boylston;J. P. Rabek;W. R. Widger.
Biochimica et Biophysica Acta (2004)
Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice
Ching Chyuan Hsieh;John Papaconstantinou.
The FASEB Journal (2006)
Carbonylation of ER chaperone proteins in aged mouse liver.
Jeffrey P. Rabek;William H. Boylston;John Papaconstantinou.
Biochemical and Biophysical Research Communications (2003)
Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro
Ramkumar Menon;Istvan Boldogh;Hal K. Hawkins;Michael Woodson.
American Journal of Pathology (2014)
Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells.
Sung Kwon Moon;Larry J. Thompson;Nageswara Madamanchi;Scott Ballinger.
American Journal of Physiology-heart and Circulatory Physiology (2001)
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