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Biology and Biochemistry

D-Index
59
Citations
11252
World Ranking
12661
National Ranking
5400

Overview

John Papaconstantinou is affiliated with The University of Texas Medical Branch at Galveston in the United States. Their work spans multiple fields, including Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Molecular Biology and Physiology as subfields.

The research topics covered by John Papaconstantinou include:

  • Fibroblast Growth Factor Research
  • Muscle Physiology and Disorders
  • Adipose Tissue and Metabolism

One noted publication by John Papaconstantinou is titled The Mechanism of Decline of Senescent Skeletal Muscle Satellite Cell Self-Renewal and Regenerative Proliferation: The Role of Heparan Sulfate-FGF-2--FGFR1-p38αMAPK Axis, Sprouty1, miR-1, miR-133 and miR-29a. This paper was published in 2020 in the Journal of Skeletal Muscle.

Their frequent publication venue includes:

  • Journal of Skeletal Muscle

John Papaconstantinou's scientific output focuses on molecular mechanisms underlying muscle physiology and regeneration, examining pathways involving fibroblast growth factors and associated molecular regulators. The research situates itself at the intersection of molecular biology and physiology, contributing to understanding cellular processes linked to muscle aging and repair.

Best Publications

  • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

    Kevin Flurkey;John Papaconstantinou;Richard A. Miller;David E. Harrison

  • Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.

    Tawfiq Alam;Mi Ra An;John Papaconstantinou

  • Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.

    Markus Grompe;Sven Lindstedt;Muhsen Al-Dhalimy;Nancy G. Kennaway

  • Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.

    Paul L. DeAngelis;John Papaconstantinou;Paul H. Weigel

  • The Snell dwarf mutation Pit1dw can increase life span in mice

    Kevin Flurkey;John Papaconstantinou;David E Harrison

  • Oxidatively damaged proteins of heart mitochondrial electron transport complexes.

    K. B. Choksi;W. H. Boylston;J. P. Rabek;W. R. Widger

  • Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice

    Ching Chyuan Hsieh;John Papaconstantinou

  • Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response.

    M. R. An;C. C. Hsieh;P. D. Reisner;J. P. Rabek

  • The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease.

    John Papaconstantinou

  • Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

    Ramkumar Menon;Istvan Boldogh;Hal K. Hawkins;Michael Woodson

  • Carbonylation of ER chaperone proteins in aged mouse liver.

    Jeffrey P. Rabek;William H. Boylston;John Papaconstantinou

  • Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells.

    Sung Kwon Moon;Larry J. Thompson;Nageswara Madamanchi;Scott Ballinger

  • Isolation of a Streptococcus pyogenes gene locus that directs hyaluronan biosynthesis in acapsular mutants and in heterologous bacteria.

    Paul L. DeAngelis;John Papaconstantinou;Paul H. Weigel

  • Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.

    Hiroshi Saito;Hiroshi Saito;John Papaconstantinou;Hiroyuki Sato;Samuel Goldstein

  • Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers.

    Jonathan E. Nuss;Kashyap B. Choksi;James H. DeFord;John Papaconstantinou

  • Tumor necrosis factor-α and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis

    Naira Baregamian;Jun Song;C. Eric Bailey;John Papaconstantinou

  • trans-activation of the alpha 1-acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor.

    Tawfiq Alam;Mi Ra An;Randy C. Mifflin;Ching Chyuan Hsieh

  • The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

    C. C. Hsieh;Makoto Kuro-o;Kevin P. Rosenblatt;Reynolds Brobey

  • Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development.

    Nisha Garg;Vsevolod L. Popov;John Papaconstantinou

  • HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes.

    Sarah Bredeson;John Papaconstantinou;James H. Deford;Talar Kechichian

Frequent Co-Authors

David E. Harrison
David E. Harrison Jackson Laboratory
Ramkumar Menon
Ramkumar Menon The University of Texas Medical Branch at Galveston
George R. Saade
George R. Saade The University of Texas Medical Branch at Galveston
Sankar Mitra
Sankar Mitra Houston Methodist
David N. Herndon
David N. Herndon The University of Texas Medical Branch at Galveston
Istvan Boldogh
Istvan Boldogh The University of Texas Medical Branch at Galveston
Makoto Kuro-o
Makoto Kuro-o Jichi Medical University
Peter B. Ernst
Peter B. Ernst University of California, San Diego
Marschall S. Runge
Marschall S. Runge University of Michigan–Ann Arbor
Timothy L. Denning
Timothy L. Denning Georgia Research Alliance

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