What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Oxidative stress, Molecular biology, Biochemistry, Reactive oxygen species and Endocrinology.
His Oxidative stress research incorporates elements of Myocarditis, Submitochondrial particle, Mitochondrial respiratory chain, Gene chip analysis and Respiratory chain.
His research in Molecular biology intersects with topics in Molecular cloning, Gene expression, Regulatory sequence and Gene isoform.
His Reactive oxygen species study combines topics from a wide range of disciplines, such as Enzyme activator, Superoxide dismutase and p38 mitogen-activated protein kinases.
The concepts of his Endocrinology study are interwoven with issues in Internal medicine, Senescence and Signal transduction.
His Internal medicine study combines topics in areas such as Fumarylacetoacetate hydrolase and Protein kinase B.
His most cited work include:
- Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production (658 citations)
- Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. (276 citations)
- Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. (265 citations)
What are the main themes of his work throughout his whole career to date?
John Papaconstantinou mainly investigates Molecular biology, Internal medicine, Endocrinology, Oxidative stress and Gene expression.
The study incorporates disciplines such as Gene isoform, Messenger RNA, Transcription and Transcription factor in addition to Molecular biology.
In his study, which falls under the umbrella issue of Internal medicine, Molecular cloning and Escherichia coli is strongly linked to Mutant.
His work carried out in the field of Endocrinology brings together such families of science as Mitogen-activated protein kinase, Signal transduction, Senescence, Longevity and Stress Response Signaling.
His Oxidative stress research incorporates themes from Reactive oxygen species and Mitochondrion.
His studies deal with areas such as Transforming growth factor and Fatty acid metabolism as well as Gene expression.
He most often published in these fields:
- Molecular biology (37.50%)
- Internal medicine (25.00%)
- Endocrinology (24.17%)
What were the highlights of his more recent work (between 2008-2019)?
- Oxidative stress (21.67%)
- Cell biology (15.83%)
- Reactive oxygen species (15.00%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Oxidative stress, Cell biology, Reactive oxygen species, Senescence and Internal medicine.
His study in Oxidative stress is interdisciplinary in nature, drawing from both Molecular biology and Membrane.
His studies in Molecular biology integrate themes in fields like Lipopolysaccharide and Cytokine.
His Cell biology study incorporates themes from Insulin receptor and Longevity.
His Senescence study integrates concerns from other disciplines, such as Pregnancy, In vivo, DNA damage and MAPK/ERK pathway.
His Internal medicine course of study focuses on Endocrinology and Stress Response Signaling and Cell type.
Between 2008 and 2019, his most popular works were:
- Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro (109 citations)
- Tumor necrosis factor-α and apoptosis signal-regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis (89 citations)
- The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging (78 citations)
In his most recent research, the most cited papers focused on:
John Papaconstantinou mainly focuses on Oxidative stress, Cell biology, Reactive oxygen species, ASK1 and Klotho.
Oxidative stress is a subfield of Biochemistry that John Papaconstantinou explores.
His Cell biology research is multidisciplinary, incorporating elements of Amnion and Insulin.
His ASK1 research overlaps with other disciplines such as Kinase, p38 mitogen-activated protein kinases, Endocrinology and Internal medicine.
His work in the fields of Thioredoxin overlaps with other areas such as MPTP and Pars compacta.
The various areas that he examines in his Klotho study include Insulin receptor, Receptor, Hormone, Signal transduction and Longevity.
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