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Molecular Biology

D-Index
108
Citations
50792
World Ranking
397
National Ranking
227

Medicine

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109
Citations
51160
World Ranking
5715
National Ranking
3072

Research.com Recognitions

  • 2002 - E. Mead Johnson Award, Society for Pediatric Research

Overview

Markus Grompe is affiliated with Oregon Health & Science University in the United States. Their research spans several fields including Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader fields, Grompe's work focuses on subfields such as Molecular Biology, Surgery, Genetics, Hepatology, and Epidemiology.

Grompe's recent papers demonstrate a focus on liver biology, gene therapy, and epigenetics. Notable publications include:

  • A DNA methylation atlas of normal human cell types (2023), published in Nature
  • AAV integration in human hepatocytes (2021), published in Molecular Therapy
  • Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice (2020), published in Molecular Therapy
  • Proliferative polyploid cells give rise to tumors via ploidy reduction (2021), published in Nature Communications
  • MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia (2020), published in Cell Stem Cell

The main topics covered in Grompe's research include:

  • Liver physiology and pathology
  • CRISPR and Genetic Engineering
  • DNA Repair Mechanisms
  • Virus-based gene therapy research
  • Pancreatic function and diabetes
  • Liver Disease Diagnosis and Treatment
  • Epigenetics and DNA Methylation

Frequent coauthors in Grompe's research work include Leslie Wakefield, Amita Tiyaboonchai, Craig Dorrell, Lander Foquet, and Anne Vonada.

Grompe's research findings have been disseminated across multiple venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Hepatology
  • Journal of Hepatology
  • Molecular Therapy

Among the recognitions received, Grompe was awarded the E. Mead Johnson Award from the Society for Pediatric Research in 2002.

Best Publications

  • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

    Eric Lagasse;Heather Connors;Muhsen Al-Dhalimy;Michael Reitsma

  • Cell fusion is the principal source of bone-marrow-derived hepatocytes

    Xin Wang;Holger Willenbring;Yassmine Akkari;Yumi Torimaru

  • A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

    Carolyn J. Brown;Andrea Ballabio;James L. Rupert;Ronald G. Lafreniere

  • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

    Meritxell Huch;Craig Dorrell;Sylvia F. Boj;Johan H. van Es

  • Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

    Irene Garcia-Higuera;Toshiyasu Taniguchi;Shridar Ganesan;M.Stephen Meyn

  • Biallelic Inactivation of BRCA2 in Fanconi Anemia

    Niall G. Howlett;Toshiyasu Taniguchi;Susan Olson;Barbara Cox

  • Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

    Hao Yin;Wen Xue;Sidi Chen;Roman L Bogorad

  • The Fanconi anaemia/BRCA pathway

    Alan D. D'Andrea;Markus Grompe

  • Robust expansion of human hepatocytes in Fah −/− / Rag2 −/− / Il2rg −/− mice

    Hisaya Azuma;Nicole Paulk;Aarati Ranade;Craig Dorrell

  • Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.

    Ken Overturf;Muhsen Al-Dhalimy;Ching Nan Ou;Milton Finegold

  • Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

    Joshua Moss;Judith Magenheim;Daniel Neiman;Hai Zemmour

  • Generation and Regeneration of Cells of the Liver and Pancreas

    Kenneth S. Zaret;Markus Grompe

  • Characterization of a murine gene expressed from the inactive X chromosome.

    Giuseppe Borsani;Rossana Tonlorenzi;M. Christine Simmler;Luisa Dandolo

  • Stem Cells and Liver Regeneration

    Andrew W. Duncan;Craig Dorrell;Markus Grompe

  • Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I

    Ken Overturf;Muhsen Al-Dhalimy;Robert Tanguay;Mark Brantly

  • Identification of tissue-specific cell death using methylation patterns of circulating DNA.

    Roni Lehmann-Werman;Daniel Neiman;Hai Zemmour;Joshua Moss

  • S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

    Toshiyasu Taniguchi;Irene Garcia-Higuera;Irene Garcia-Higuera;Paul R. Andreassen;Paul R. Andreassen;Richard C. Gregory;Richard C. Gregory

  • The rapid detection of unknown mutations in nucleic acids.

    Markus Grompe

  • The origin and liver repopulating capacity of murine oval cells

    Xin Wang;Mark Foster;Muhsen Al-Dhalimy;Eric Lagasse

  • The ploidy conveyor of mature hepatocytes as a source of genetic variation

    Andrew W. Duncan;Matthew H. Taylor;Raymond D. Hickey;Amy E. Hanlon Newell

Frequent Co-Authors

Milton J. Finegold
Milton J. Finegold Baylor College of Medicine
Alan D. D'Andrea
Alan D. D'Andrea Dana-Farber Cancer Institute
Susan B. Olson
Susan B. Olson Oregon Health & Science University
Mark A. Kay
Mark A. Kay Stanford University
Grover C. Bagby
Grover C. Bagby Oregon Health & Science University
Toshiyasu Taniguchi
Toshiyasu Taniguchi Fred Hutchinson Cancer Research Center
Jonathan Schug
Jonathan Schug University of Pennsylvania
Klaus H. Kaestner
Klaus H. Kaestner University of Pennsylvania
Eugenio Montini
Eugenio Montini IRCCS Ospedale San Raffaele
Yuval Dor
Yuval Dor Hebrew University of Jerusalem

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