World's Best Scientists 2026 revealed!

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Microbiology

D-Index
77
Citations
19331
World Ranking
1362
National Ranking
596

Medicine

D-Index
77
Citations
19355
World Ranking
18515
National Ranking
9228

Overview

Stefan H. I. Kappe is affiliated with the University of Washington in the United States. Their research primarily focuses on malaria, infectious diseases, and immunology-related topics. They have contributed extensively to understanding malaria biology, parasite-host interactions, and mechanisms of drug resistance.

Their recent publications include a range of papers on malaria parasite biology and experimental models, such as:

  • Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools, 2021, Annual Review of Microbiology
  • Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1, 2023, Nature Microbiology
  • A replication-competent late liver stage-attenuated human malaria parasite, 2020, JCI Insight
  • A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection, 2020, iScience
  • A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection, 2022, Science Translational Medicine

Kappe has frequently collaborated with several coauthors, including:

  • Ashley M. Vaughan
  • Sudhir Kumar
  • Meseret T. Haile
  • Nelly Camargo
  • Biley A. Abatiyow

Their work has appeared regularly in multiple scientific journals and platforms, with notable frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience
  • mBio
  • The Journal of Immunology
  • Nature Microbiology

Kappe's main fields of study include Medicine and Immunology and Microbiology. Within these broader areas, subfields of research consist of:

  • Public Health, Environmental and Occupational Health
  • Immunology
  • Molecular Biology
  • Parasitology
  • Oncology

Their primary research topics span various aspects of malaria and related infectious diseases, including:

  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Invertebrate Immune Response Mechanisms
  • Drug Transport and Resistance Mechanisms
  • Parasites and Host Interactions
  • Trypanosoma species research and implications
  • Complement system in diseases

Best Publications

  • Malaria: progress, perils, and prospects for eradication

    Brian M. Greenwood;David A. Fidock;Dennis E. Kyle;Stefan H.I. Kappe

  • Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

    Ann-Kristin Mueller;Mehdi Labaied;Stefan H. I. Kappe;Stefan H. I. Kappe;Kai Matuschewski

  • Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interface

    Ann-Kristin Mueller;Nelly Camargo;Karine Kaiser;Cathy Andorfer

  • Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

    Ashley M Vaughan;Matthew T O'Neill;Alice S Tarun;Nelly Camargo

  • Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host

    Ahmed S.I. Aly;Ashley M. Vaughan;Stefan H.I. Kappe

  • A combined transcriptome and proteome survey of malaria parasite liver stages.

    Alice S. Tarun;Xinxia Peng;Ronald F. Dumpit;Yuko Ogata

  • Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

    Andrew S Ishizuka;Kirsten E Lyke;Adam DeZure;Andrea A Berry

  • Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

    Peter Liehl;Vanessa Zuzarte-Luís;Jennie Chan;Thomas Zillinger

  • Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites

    Stefan Kappe;Thomas Bruderer;Soren Gantt;Hisashi Fujioka

  • That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

    Stefan H. I. Kappe;Stefan H. I. Kappe;Ashley M. Vaughan;Justin A. Boddey;Alan F. Cowman

  • Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature.

    Kerstin Baer;Christian Klotz;Stefan H. I Kappe;Thomas Schnieder

  • A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

    Neville K. Kisalu;Azza H. Idris;Connor Weidle;Yevel Flores-Garcia

  • Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

    Noah S. Butler;Nathan W. Schmidt;Ashley M. Vaughan;Ahmed S. Aly

  • Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

    Ashley M. Vaughan;Sebastian A. Mikolajczak;Elizabeth M. Wilson;Markus Grompe

  • Myosin A tail domain interacting protein (MTIP) localizes to the inner membrane complex of Plasmodium sporozoites.

    Lawrence W. Bergman;Karine Kaiser;Hisashi Fujioka;Isabelle Coppens

  • Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics.

    Kristian E. Swearingen;Scott E. Lindner;Scott E. Lindner;Lirong Shi;Melanie J. Shears

  • Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

    Sebastian A. Mikolajczak;Ashley M. Vaughan;Niwat Kangwanrangsan;Wanlapa Roobsoong

  • Infectivity-associated Changes in the Transcriptional Repertoire of the Malaria Parasite Sporozoite Stage

    Kai Matuschewski;Kai Matuschewski;Jessica Ross;Stuart M. Brown;Karine Kaiser

  • Interferon-mediated innate immune responses against malaria parasite liver stages.

    Jessica L. Miller;Brandon K. Sack;Michael Baldwin;Ashley M. Vaughan

  • A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

    Joshua Tan;Joshua Tan;Brandon K Sack;David Oyen;Isabelle Zenklusen;Isabelle Zenklusen

  • Release of Hepatic Plasmodium yoelii Merozoites into the Pulmonary

    Microvasculature Baer;Christian Klotz;Stefan H. I. Kappe;Thomas Schnieder

Frequent Co-Authors

Ashley M. Vaughan
Ashley M. Vaughan Seattle Children's Hospital
Jetsumon Sattabongkot
Jetsumon Sattabongkot Mahidol University
Patrick E. Duffy
Patrick E. Duffy National Institute of Allergy and Infectious Diseases
James G. Kublin
James G. Kublin Fred Hutchinson Cancer Research Center
Alan F. Cowman
Alan F. Cowman Walter and Eliza Hall Institute of Medical Research
Photini Sinnis
Photini Sinnis Johns Hopkins University
Robert L. Moritz
Robert L. Moritz Institute for Systems Biology
François Nosten
François Nosten MORU Mahidol Oxford Tropical Medicine Research Unit
Dennis E. Kyle
Dennis E. Kyle University of Georgia

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