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Microbiology

D-Index
63
Citations
14803
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2721
National Ranking
1094

Overview

Thomas L. Richie is affiliated with the Naval Medical Research Center in the United States. Their research portfolio focuses primarily on medicine, with significant contributions to public health, environmental and occupational health, molecular biology, immunology, parasitology, and infectious diseases. The overarching themes of their work revolve around malaria research and control, mosquito-borne diseases, vaccines and immunoinformatics approaches, travel-related health issues, parasites and host interactions, the complement system in diseases, and vector-borne infectious diseases.

Richie has published extensively on malaria and infectious diseases, with notable recent papers including:

  • Ethics of controlled human infection to address COVID-19, 2020, Science
  • Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity, 2021, Nature
  • Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial, 2021, Nature Medicine
  • A double-blind, placebo-controlled phase 1/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1, 2020, Science Translational Medicine
  • Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial, 2021, The Lancet Infectious Diseases

Their frequent co-authors include Stephen L. Hoffman, B. Kim Lee Sim, Peter F. Billingsley, Tooba Murshedkar, and Eric R. James. These collaborators have appeared in numerous publications alongside Richie, indicating a collaborative research environment centered on malaria vaccine development and infectious disease control.

Richie's work has appeared in several recurring publication venues, such as:

  • American Journal of Tropical Medicine and Hygiene
  • The Lancet Infectious Diseases
  • PLoS ONE
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine

The scientific topics addressed in Richie's research emphasize the control and understanding of mosquito-borne diseases and malaria. A focus on vaccines is evident, alongside investigations into host-parasite interactions and immunological responses relevant to infectious diseases. Their contributions span clinical trials, immunogenicity studies, and ethical considerations in controlled human infection models to address emergent and endemic diseases.

Best Publications

  • Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites

    Stephen L. Hoffman;Lucy M. L. Goh;Thomas C. Luke;Imogene Schneider

  • Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

    Robert A. Seder;Lee Jah Chang;Mary E. Enama;Kathryn L. Zephir

  • Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity

    J. E. Epstein;K. Tewari;K. E. Lyke;B. K. L. Sim

  • Progress and challenges for malaria vaccines.

    Thomas L. Richie;Allan Saul

  • Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

    Benjamin Mordmüller;Güzin Surat;Heimo Lagler;Heimo Lagler;Sumana Chakravarty

  • Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

    Andrew S Ishizuka;Kirsten E Lyke;Adam DeZure;Andrea A Berry

  • Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria.

    Stephen L Hoffman;Peter F Billingsley;Eric James;Adam Richman

  • Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial

    Mahamadou S Sissoko;Sara A Healy;Abdoulaye Katile;Freda Omaswa

  • Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccine

    Ruobing Wang;Judith Epstein;Fe Maria Baraceros;Edward J. Gorak

  • Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells.

    Rebecca Danner;Snehal N. Chaudhari;John Rosenberger;Jacqueline Surls

  • Protection against Plasmodium falciparum malaria by PfSPZ Vaccine

    Judith E. Epstein;Kristopher M. Paolino;Thomas L. Richie;Martha Sedegah

  • Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection

    Kirsten E. Lyke;Andrew S. Ishizuka;Andrea A. Berry;Sumana Chakravarty

  • The RTS,S malaria vaccine

    Sofia Casares;Teodor-Doru Brumeanu;Thomas L. Richie

  • A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

    S. J. Dunachie;M. Walther;J. E. Epstein;S. Keating

  • The March Toward Malaria Vaccines

    Stephen L. Hoffman;Johan Vekemans;Thomas L. Richie;Patrick E. Duffy

  • Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines.

    Thomas L. Richie;Peter F. Billingsley;B. Kim Lee Sim;Eric R. James

  • Update on the clinical development of candidate malaria vaccines

    W. Ripley Ballou;Myriam Arevalo-Herrera;Daniel Carucci;Thomas L. Richie

  • Mefloquine Compared with Doxycycline for the Prophylaxis of Malaria in Indonesian Soldiers: A Randomized, Double-Blind, Placebo-Controlled Trial

    C Ohrt;T L Richie;H Widjaja;G D Shanks

  • Sterile Protective Immunity to Malaria is Associated with a Panel of Novel P. falciparum Antigens

    Angela Trieu;Matthew A. Kayala;Chad Burk;Douglas M. Molina

  • Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia.

    Walter R. J. Taylor;Thomas L. Richie;David J. Fryauff;Helena Picarima

Frequent Co-Authors

Martha Sedegah
Martha Sedegah Naval Medical Research Center
Denise L. Doolan
Denise L. Doolan Australian Institute of Tropical Health and Medicine
Marcel Tanner
Marcel Tanner Swiss Tropical and Public Health Institute
Daniel J. Carucci
Daniel J. Carucci Naval Medical Research Center
Robert A. Seder
Robert A. Seder National Institute of Allergy and Infectious Diseases
Benjamin Mordmüller
Benjamin Mordmüller Radboud University Medical Center
Christian F. Ockenhouse
Christian F. Ockenhouse Walter Reed Army Institute of Research
Patrick E. Duffy
Patrick E. Duffy National Institute of Allergy and Infectious Diseases

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