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Immunology

D-Index
74
Citations
17510
World Ranking
2069
National Ranking
1010

Overview

Christian F. Ockenhouse is affiliated with the Walter Reed Army Institute of Research in the United States. Their research activity primarily spans the field of medicine with a focus on public health, environmental and occupational health, infectious diseases, molecular biology, computational theory and mathematics, and general health topics.

The scientist's work centers around several main topics, including:

  • Malaria Research and Control
  • Mosquito-borne diseases and control
  • Computational Drug Discovery Methods
  • Vaccines and immunoinformatics approaches
  • Vaccine Coverage and Hesitancy
  • SARS-CoV-2 and COVID-19 Research
  • Invertebrate Immune Response Mechanisms

Ockenhouse has authored multiple research papers in a variety of journals and scientific venues. Notable recent papers include:

  • "Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial," 2020, published in Trials
  • "Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention," 2021, published in New England Journal of Medicine
  • "Efficacy of RTS,S/AS01E malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5-17 months in Ghana and Kenya: an open-label, phase 2b, randomised controlled trial," 2022, published in The Lancet Infectious Diseases
  • "Seasonal vaccination with RTS,S/AS01E vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial," 2023, published in The Lancet Infectious Diseases
  • "A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults," 2020, published in The Journal of Infectious Diseases

The scientist frequently publishes in venues such as:

  • The Journal of Infectious Diseases
  • The Lancet Infectious Diseases
  • Malaria Journal
  • Zenodo (CERN European Organization for Nuclear Research)
  • Vaccine

Ockenhouse has collaborated extensively with a number of peers, including:

  • Cynthia Lee
  • Opokua Ofori-Anyinam
  • Marc Lievens
  • Erik Jongert
  • Karen Ivinson

Best Publications

  • Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

    Kent E. Kester;James F. Cummings;Opokua Ofori-Anyinam;Christian F. Ockenhouse

  • Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity

    J. E. Epstein;K. Tewari;K. E. Lyke;B. K. L. Sim

  • Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1.

    C. F. Ockenhouse;T. Tegoshi;Y. Maeno;C. Benjamin

  • Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

    Daniel E Neafsey;Michal Juraska;Trevor Bedford;David Benkeser

  • Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor

    Christian F. Ockenhouse;Narendra N. Tandon;Cathleen Magowan;G. A. Jamieson

  • Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

    James J. Moon;Heikyung Suh;Heikyung Suh;Adrienne Victoria Li;Christian F. Ockenhouse

  • Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.

    Bernhards R. Ogutu;Odika J. Apollo;Denise McKinney;Willis Okoth

  • Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria

    Kent E. Kester;Denise A. McKinney;Nadia Tornieporth;Christian F. Ockenhouse

  • Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis.

    Ramachandra S. Naik;Ora Lee H. Branch;Amina S. Woods;Matam Vijaykumar

  • Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC-Pf7, a Pox-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria

    Christian F. Ockenhouse;Pei Fang Sun;David E. Lanar;Bruce T. Wellde

  • Long-Term Efficacy and Immune Responses following Immunization with the RTS,S Malaria Vaccine

    J A Stoute;K E Kester;U Krzych;B T Wellde

  • Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

    Jason W. Bennett;Brandon S. Pybus;Anjali Yadava;Donna Tosh

  • Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1.

    C. F. Ockenhouse;May Ho;N. N. Tandon;G. A. Van Seventer

  • Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial.

    Ricardo Palacios;Elizabeth González Patiño;Roberta de Oliveira Piorelli;Monica Tilli Reis Pessoa Conde

  • Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

    Dmitri Kazmin;Helder I Nakaya;Eva K Lee;Matthew J Johnson

  • Characterization of proteoglycans of human placenta and identification of unique chondroitin sulfate proteoglycans of the intervillous spaces that mediate the adherence of Plasmodium falciparum-infected erythrocytes to the placenta.

    Rajeshwara N. Achur;Manojkumar Valiyaveettil;Abdulnaser Alkhalil;Christian F. Ockenhouse

  • Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

    D. Gray Heppner;Kent E. Kester;Christian F. Ockenhouse;Nadia Tornieporth

  • Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus

    Christian F. Ockenhouse;Rajashekhar Betageri;Timothy A. Springer;Donald E. Staunton

  • Development of a Highly Sensitive Genus-Specific Quantitative Reverse Transcriptase Real-Time PCR Assay for Detection and Quantitation of Plasmodium by Amplifying RNA and DNA of the 18S rRNA Genes

    Edwin Kamau;LaDonna S. Tolbert;Luke Kortepeter;Michael Pratt

  • Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

    Michele D. Spring;James F. Cummings;Christian F. Ockenhouse;Sheetij Dutta

  • Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

    Jason A. Regules;Susan B. Cicatelli;Jason W. Bennett;Kristopher M. Paolino

  • Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy.

    Iona O'Neil-Dunne;Iona O'Neil-Dunne;Rajeshwara N. Achur;Sean T. Agbor-Enoh;Sean T. Agbor-Enoh;Sean T. Agbor-Enoh;Manojkumar Valiyaveettil

Frequent Co-Authors

W. Ripley Ballou
W. Ripley Ballou International AIDS Vaccine Initiative
Kent E. Kester
Kent E. Kester Walter Reed Army Institute of Research
Joe Cohen
Joe Cohen GlaxoSmithKline (United Kingdom)
D. Gray Heppner
D. Gray Heppner Crozet BioPharma
Urszula Krzych
Urszula Krzych United States Army Research Laboratory
David E. Lanar
David E. Lanar Walter Reed Army Institute of Research
Martha Sedegah
Martha Sedegah Naval Medical Research Center
D. Channe Gowda
D. Channe Gowda University of Mysore
Thomas L. Richie
Thomas L. Richie Naval Medical Research Center
Robert W. Sauerwein
Robert W. Sauerwein Radboud University

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