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Immunology

D-Index
63
Citations
14240
World Ranking
3027
National Ranking
1420

Overview

D. Gray Heppner is affiliated with Crozet BioPharma in the United States and has contributed to research primarily within the field of Medicine. Their work spans multiple subfields including Infectious Diseases, Public Health, Environmental and Occupational Health, Molecular Biology, and Immunology.

The scientist's research focuses heavily on SARS-CoV-2 and COVID-19, with an emphasis on clinical research studies related to COVID-19 as well as vaccine development and immunoinformatics approaches. Additionally, Heppner has been involved in studies related to Malaria Research and Control, mosquito-borne diseases, and the complement system in diseases.

Recent publications include:

  • A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2 (2022), published in Emerging Microbes & Infections
  • A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naïve adults (2024), published in Vaccine

Frequent collaborators in research include:

  • Shixia Wang
  • Chang Yi Wang
  • Hui-Kai Kuo
  • Wen-Jiun Peng
  • Juin-Hua Huang

Heppner's work has appeared predominantly in the journals Emerging Microbes & Infections and Vaccine, reflecting their focus on infectious disease and immunological research within clinical and public health contexts.

Best Publications

  • A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group.

    J A Stoute;M Slaoui;D G Heppner;P Momin

  • Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites

    Stephen L. Hoffman;Lucy M. L. Goh;Thomas C. Luke;Imogene Schneider

  • Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans.

    Samuel J McConkey;William H H Reece;Vasee S Moorthy;Daniel Webster

  • Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

    Kent E. Kester;James F. Cummings;Opokua Ofori-Anyinam;Christian F. Ockenhouse

  • A field trial to assess a blood-Stage malaria vaccine

    Mahamadou A. Thera;Ogobara K. Doumbo;Drissa Coulibaly;Matthew B. Laurens

  • Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine.

    D. M. Gordon;T. W. McGovern;U. Krzych;J. C. Cohen

  • Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.

    Bernhards R. Ogutu;Odika J. Apollo;Denise McKinney;Willis Okoth

  • Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria

    Kent E. Kester;Denise A. McKinney;Nadia Tornieporth;Christian F. Ockenhouse

  • Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway

    Sathit Pichyangkul;Kosol Yongvanitchit;Utaiwan Kum-arb;Hiroaki Hemmi

  • Protective Immunity Induced with Malaria Vaccine, RTS,S, Is Linked to Plasmodium falciparum Circumsporozoite Protein-Specific CD4+ and CD8+ T Cells Producing IFN-γ

    Peifang Sun;Robert Schwenk;Katherine White;Jose A. Stoute

  • Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

    D. Gray Heppner;Kent E. Kester;Christian F. Ockenhouse;Nadia Tornieporth

  • Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand

    F Nosten;C Luxemburger;D E Kyle;W R Ballou

  • Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

    Michele D. Spring;James F. Cummings;Christian F. Ockenhouse;Sheetij Dutta

  • Update on the clinical development of candidate malaria vaccines

    W. Ripley Ballou;Myriam Arevalo-Herrera;Daniel Carucci;Thomas L. Richie

  • Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

    Kelley M. VanBuskirk;Matthew T. O'Neill;Patricia De La Vega;Alexander G. Maier

  • Salmonella typhi Vaccine Strain CVD 908 Expressing the Circumsporozoite Protein of Plasmodium falciparum: Strain Construction and Safety and Immunogenicity in Humans

    C. Gonzalez;D. Hone;F. R. Noriega;C. O. Tacket

  • Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children.

    Suharyono;C Simanjuntak;H Totosudirjo;N Witham

  • Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria

    Christian F. Ockenhouse;Wan Chung Hu;Kent E. Kester;James F. Cummings

  • First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.

    Michele Spring;Jittawadee Murphy;Robin Nielsen;Megan Dowler

  • Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.

    Mahamadou A. Thera;Ogobara K. Doumbo;Drissa Coulibaly;Dapa A. Diallo

Frequent Co-Authors

Joe Cohen
Joe Cohen GlaxoSmithKline (United Kingdom)
Kent E. Kester
Kent E. Kester Walter Reed Army Institute of Research
W. Ripley Ballou
W. Ripley Ballou International AIDS Vaccine Initiative
David E. Lanar
David E. Lanar Walter Reed Army Institute of Research
Christian F. Ockenhouse
Christian F. Ockenhouse Walter Reed Army Institute of Research
Urszula Krzych
Urszula Krzych United States Army Research Laboratory
Christopher V. Plowe
Christopher V. Plowe University of Maryland, Baltimore
Amanda J. Leach
Amanda J. Leach Charles Darwin University
Ogobara K. Doumbo
Ogobara K. Doumbo University of Bamako
Arthur M. Krieg
Arthur M. Krieg University of Massachusetts Chan Medical School

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