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Immunology

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44
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8728
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Overview

Urszula Krzych is affiliated with the United States Army Research Laboratory in the United States and has contributed extensively to research in medicine, immunology, and microbiology. Their work concentrates on several subfields, including public health, environmental and occupational health, immunology, epidemiology, virology, and parasitology.

The primary research topics addressed in their publications include malaria research and control, the complement system in diseases, mosquito-borne diseases and control, hepatitis B virus studies, immunotherapy and immune responses, HIV research and treatment, and parasites and host interactions.

Krzych has published research in several scientific venues, with frequent publications in:

  • Critical Reviews in Immunology
  • The Journal of Immunology
  • Infection and Immunity
  • Vaccine
  • European Journal of Immunology

Their recent papers include:

  • Plasmodium Preerythrocytic Vaccine Antigens Enhance Sterile Protection in Mice Induced by Circumsporozoite Protein, 2021, Infection and Immunity
  • A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naïve adults, 2024, Vaccine
  • The Form of an Antigen and Its Molecular Context Do Matter: Infectious versus Attenuated Plasmodium Sporozoites, 2020, Critical Reviews in Immunology
  • Eli's Propinquity is Far Reaching, from Escherichia coli β-Galactosidase to the Plasmodium Parasite, 2020, Critical Reviews in Immunology
  • Prime-Trap immunization with protective liver stage antigen, MIF-4G and Kb17 peptide, induces liver CD8 TRM cells and protection against Plasmodium berghei malaria, 2021, The Journal of Immunology

Krzych has collaborated frequently with several coauthors, including:

  • Alexander Pichugin
  • Nouf Althubaiti
  • Patrick E. Duffy
  • Jonathan P. Renn
  • Sarat K. Dalai

Their multi-disciplinary research intersects infectious disease immunology and vaccine development, especially focusing on malaria and mosquito-borne diseases. The work contributes to understanding antigen forms in vaccine efficacy and the immune response in liver-stage malaria protection.

Best Publications

  • A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group.

    J A Stoute;M Slaoui;D G Heppner;P Momin

  • Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

    Kent E. Kester;James F. Cummings;Opokua Ofori-Anyinam;Christian F. Ockenhouse

  • Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine.

    D. M. Gordon;T. W. McGovern;U. Krzych;J. C. Cohen

  • Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria

    Kent E. Kester;Denise A. McKinney;Nadia Tornieporth;Christian F. Ockenhouse

  • Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC-Pf7, a Pox-Vectored, Multiantigen, Multistage Vaccine Candidate for Plasmodium falciparum Malaria

    Christian F. Ockenhouse;Pei Fang Sun;David E. Lanar;Bruce T. Wellde

  • Long-Term Efficacy and Immune Responses following Immunization with the RTS,S Malaria Vaccine

    J A Stoute;K E Kester;U Krzych;B T Wellde

  • The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site.

    G. Gammon;Nilabh Shastri;J. Cogswell;S. Wilbur

  • Protective Immunity Induced with Malaria Vaccine, RTS,S, Is Linked to Plasmodium falciparum Circumsporozoite Protein-Specific CD4+ and CD8+ T Cells Producing IFN-γ

    Peifang Sun;Robert Schwenk;Katherine White;Jose A. Stoute

  • Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

    D. Gray Heppner;Kent E. Kester;Christian F. Ockenhouse;Nadia Tornieporth

  • Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

    Michele D. Spring;James F. Cummings;Christian F. Ockenhouse;Sheetij Dutta

  • Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

    Kelley M. VanBuskirk;Matthew T. O'Neill;Patricia De La Vega;Alexander G. Maier

  • Genetically Attenuated Plasmodium berghei Liver Stages Induce Sterile Protracted Protection That Is Mediated by Major Histocompatibility Complex Class I-Dependent Interferon-γ-Producing CD8+ T Cells

    Ousman Jobe;Joanne Lumsden;Ann-Kristin Mueller;Jackie Williams

  • First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.

    Michele Spring;Jittawadee Murphy;Robin Nielsen;Megan Dowler

  • Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research.

    Kent E. Kester;James F. Cummings;Christian F. Ockenhouse;Robin Nielsen

  • A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults

    Kent E. Kester;Denise A. Mckinney;Nadia Tornieporth;Christian F. Ockenhouse

  • T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens.

    U Krzych;J A Lyon;T Jareed;I Schneider

  • Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.

    Mark E. Polhemus;Mark E. Polhemus;Alan J. Magill;James F. Cummings;Kent E. Kester

  • Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine.

    L.S Rickman;R Wistar;S.L Hoffman;D.M Gordon

  • Reduced Cord Blood Immune Effector-Cell Responsiveness Mediated by CD4 + Cells Induced in Utero as a Consequence of Placental Plasmodium falciparum Infection

    Kim Brustoski;Kim Brustoski;Ulrike Möller;Martin Kramer;Franca C. Hartgers

  • Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

    James F. Cummings;Michele D. Spring;Robert J. Schwenk;Christian F. Ockenhouse

Frequent Co-Authors

Kent E. Kester
Kent E. Kester Walter Reed Army Institute of Research
D. Gray Heppner
D. Gray Heppner Crozet BioPharma
W. Ripley Ballou
W. Ripley Ballou International AIDS Vaccine Initiative
Joe Cohen
Joe Cohen GlaxoSmithKline (United Kingdom)
Christian F. Ockenhouse
Christian F. Ockenhouse Walter Reed Army Institute of Research
David E. Lanar
David E. Lanar Walter Reed Army Institute of Research
Patrick E. Duffy
Patrick E. Duffy National Institute of Allergy and Infectious Diseases
Carl R. Alving
Carl R. Alving Walter Reed Army Institute of Research
Stefan H. I. Kappe
Stefan H. I. Kappe University of Washington
Adrian J. F. Luty
Adrian J. F. Luty Institut de Recherche pour le Développement

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