World's Best Scientists 2026 revealed!
Tak Hang Chan

Tak Hang Chan

D-Index & Metrics

Chemistry

D-Index
74
Citations
20236
World Ranking
4663
National Ranking
112

Overview

Tak Hang Chan is affiliated with McGill University in Canada and has a multidisciplinary research profile spanning medicine and materials science.

The scientist's work broadly covers the subfields of materials chemistry, oncology, molecular biology, pathology and forensic medicine, as well as infectious diseases. Within these areas, their research topics include:

  • Crystallization and solubility studies
  • X-ray diffraction in crystallography
  • Drug transport and resistance mechanisms
  • Pharmacological effects and toxicity studies
  • HIV/AIDS drug development and treatment
  • Endometriosis research and treatment
  • Tea polyphenols and effects

Publications appear frequently in these venues:

  • The Cambridge Structural Database
  • International Journal of Molecular Sciences
  • Journal of Medicinal Chemistry
  • Frontiers in Pharmacology
  • BMC Cancer

Recent scientific papers authored or coauthored by Tak Hang Chan include:

  • Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer (2020, BMC Cancer)
  • SALL4 promotes tumor progression in breast cancer by targeting EMT (2020, Molecular Carcinogenesis)
  • Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors (2020, Bioorganic Chemistry)
  • Disruption of SND1-MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo (2020, Molecular Cancer Therapeutics)
  • In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31 (2023, International Journal of Molecular Sciences)

The scientist has collaborated extensively with the following researchers:

  • Larry M. C. Chow
  • Iris L. K. Wong
  • R.N. Rutherford
  • S. Ura
  • Andrea Renzetti

Best Publications

  • Organic reactions in aqueous media

    Chao-Jun Li;Tak-Hang Chan

  • Organic syntheses using indium-mediated and catalyzed reactions in aqueous media

    Chao-Jun Li;Tak-Hang Chan

  • Ionic-Liquid-Supported Synthesis: A Novel Liquid-Phase Strategy for Organic Synthesis

    Weishi Miao;Tak Hang Chan

  • ELECTROPHILIC SUBSTITUTION OF ORGANOSILICON COMPOUNDS - APPLICATIONS TO ORGANIC SYNTHESIS

    T. H. Chan;Ian Fleming

  • Comprehensive Organic Reactions in Aqueous Media

    Chao-Jun Li;Tak-Hang Chan

  • Organometallic reactions in aqueous media with indium

    C.J. Li;T.H. Chan

  • Use of Organosilicon Reagents as Protective Groups in Organic Synthesis

    M. Lalonde;T. H. Chan

  • A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent.

    Kristin R. Landis-Piwowar;Congde Huo;Di Chen;Vesna Milacic

  • Chemistry of enol silyl ethers. 5. A novel cycloaromatization reaction. Regiocontrolled synthesis of substituted methyl salicylates

    Tak-Hang Chan;Peter Brownbridge

  • EGCG, GREEN TEA POLYPHENOLS AND THEIR SYNTHETIC ANALOGS AND PRODRUGS FOR HUMAN CANCER PREVENTION AND TREATMENT

    Di Chen;Sheng Biao Wan;Huanjie Yang;Jian Yuan

  • Tea polyphenols, their biological effects and potential molecular targets

    Di Chen;Vesna Milacic;Marina Si Chen;Sheng Biao Wan

  • Ionic‐Liquid‐Supported Organocatalyst: Efficient and Recyclable Ionic‐Liquid‐Anchored Proline for Asymmetric Aldol Reaction

    Weishi Miao;Tak Hang Chan

  • Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning.

    T Chan;M Lee;T.P. Sakmar

  • Exploration of ionic liquids as soluble supports for organic synthesis. Demonstration with a Suzuki coupling reaction.

    Weishi Miao;Tak Hang Chan

  • The proteasome as a potential target for novel anticancer drugs and chemosensitizers.

    Kristin R. Landis-Piwowar;Vesna Milacic;Di Chen;Huanjie Yang

  • 1993 R.U. Lemieux Award Lecture Organometallic-type reactions in aqueous media—a new challenge in organic synthesis

    T.H. Chan;C.J. Li;M.C. Lee;Z.Y. Wei

  • A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (−)-epigallocatechin gallate [(−)-EGCG]

    Wai Har Lam;Aslamuzzaman Kazi;Deborah J. Kuhn;Larry M.C. Chow

  • Chemistry of enol silyl ethers. A general synthesis of 3-hydroxyhomophthalates and a biomimetic synthesis of sclerin

    P. Brownbridge;T. H Chan;M. A. Brook;G. J. Kang

  • Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles by a New Class of Chiral Ferrocenyl P/S Ligands

    Hong Yee Cheung;Wing-Yiu Yu;Fuk Loi Lam;Terry T.-L. Au-Yeung

  • Chiral organosilicon compounds in asymmetric synthesis

    T. H. Chan;D. Wang

  • Synthetic Analogs of Green Tea Polyphenols as Proteasome Inhibitors

    David M. Smith;Zhigang Wang;Aslamuzzaman Kazi;Lian Hai Li

Frequent Co-Authors

Kwok-Yin Wong
Kwok-Yin Wong Hong Kong Polytechnic University
Q. Ping Dou
Q. Ping Dou Wayne State University
Chao-Jun Li
Chao-Jun Li McGill University
Masad J. Damha
Masad J. Damha McGill University
Sheng Chen
Sheng Chen University of Southampton
Michael A. Brook
Michael A. Brook McMaster University
Zhongyuan Zhou
Zhongyuan Zhou Hong Kong Polytechnic University
Ruben Abagyan
Ruben Abagyan University of California, San Diego
Dik-Lung Ma
Dik-Lung Ma Hong Kong Baptist University
Dingsheng Wang
Dingsheng Wang Tsinghua University

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