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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
133
Citations
64871
World Ranking
166
National Ranking
105

Medicine

D-Index
136
Citations
66325
World Ranking
1986
National Ranking
1127

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Alan D. D'Andrea is affiliated with Harvard University in the United States and contributes extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans primary fields such as Molecular Biology and Oncology, with subfields including Genetics, Cancer Research, and Pathology and Forensic Medicine.

The research topics Alan D. D'Andrea focuses on include:

  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • Cancer-related Molecular Pathways
  • CRISPR and Genetic Engineering
  • Cancer Genomics and Diagnostics
  • BRCA gene mutations in cancer
  • Ovarian cancer diagnosis and treatment

They have numerous publications in prominent venues, with frequent appearances in:

  • Cancer Research (24 publications)
  • Journal of Clinical Oncology (11 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (10 publications)
  • Nature Communications (7 publications)
  • Molecular Cell (4 publications)

Recent papers by Alan D. D'Andrea include:

  • TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes, 2020, Journal of Clinical Oncology
  • Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer, 2020, Nature Communications
  • A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors, 2021, Nature Cancer
  • Targeting replication stress in cancer therapy, 2022, Nature Reviews Drug Discovery
  • Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial, 2020, The Lancet Oncology

Frequent co-authors collaborating with Alan D. D'Andrea include:

  • Geoffrey I. Shapiro (54 collaborations)
  • Kalindi Parmar (28 collaborations)
  • Bose Kochupurakkal (26 collaborations)
  • Huy Nguyen (21 collaborations)
  • Lisa A. Moreau (18 collaborations)

Alan D. D'Andrea has received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

    Ross L. Levine;Ross L. Levine;Martha Wadleigh;Jan Cools;Benjamin L. Ebert;Benjamin L. Ebert

  • Repair Pathway Choices and Consequences at the Double-Strand Break

    Raphael Ceccaldi;Beatrice Rondinelli;Alan D. D’Andrea

  • Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

    Irene Garcia-Higuera;Toshiyasu Taniguchi;Shridar Ganesan;M.Stephen Meyn

  • Biallelic Inactivation of BRCA2 in Fanconi Anemia

    Niall G. Howlett;Toshiyasu Taniguchi;Susan Olson;Barbara Cox

  • Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

    Shih-Feng Tsai;David I. K. Martin;David I. K. Martin;Leonard I. Zon;Leonard I. Zon;Alan D. D'Andrea;Alan D. D'Andrea

  • Expression cloning of the murine erythropoietin receptor.

    Alan D. D'Andrea;Alan D. D'Andrea;Harvey F. Lodish;Gordon G. Wong

  • The Fanconi anaemia/BRCA pathway

    Alan D. D'Andrea;Markus Grompe

  • Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer

    Panagiotis A. Konstantinopoulos;Raphael Ceccaldi;Geoffrey I. Shapiro;Alan D. D'Andrea

  • Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

    Agata Smogorzewska;Agata Smogorzewska;Shuhei Matsuoka;Patrizia Vinciguerra;E. Robert McDonald

  • How the Fanconi Anemia Pathway Guards the Genome

    George Lucian Moldovan;Alan D. D'Andrea

  • Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

    Raphael Ceccaldi;Jessica C. Liu;Ravindra Amunugama;Ildiko Hajdu

  • Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors.

    Toshiyasu Taniguchi;Marc Tischkowitz;Najim Ameziane;Shirley V. Hodgson

  • Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.

    Kyle C. Strickland;Brooke E Howitt;Sachet A Shukla;Scott J. Rodig

  • The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

    Sebastian M.B. Nijman;Tony T. Huang;Annette M.G. Dirac;Thijn R. Brummelkamp

  • The Fanconi anaemia pathway: new players and new functions

    Raphael Ceccaldi;Prabha Sarangi;Alan D. D'Andrea

  • Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha.

    Shoumo Bhattacharya;Richard Eckner;Richard Eckner;Steven Grossman;Elizabeth Oldread

  • Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

    Hyungjin Kim;Alan D. D'Andrea

  • Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor.

    Jing-Po Li;Alan D. D'Andrea;Alan D. D'Andrea;Alan D. D'Andrea;Harvey F. Lodish;David Baltimore

  • Regulation of monoubiquitinated PCNA by DUB autocleavage

    Tony T. Huang;Sebastian M.B. Nijman;Kanchan D. Mirchandani;Paul J. Galardy

  • Chromatin Remodeling at DNA Double-Strand Breaks

    Brendan D. Price;Alan D. D’Andrea

Frequent Co-Authors

Geoffrey I. Shapiro
Geoffrey I. Shapiro Harvard University
Markus Grompe
Markus Grompe Oregon Health & Science University
Ursula A. Matulonis
Ursula A. Matulonis Harvard University
Toshiyasu Taniguchi
Toshiyasu Taniguchi Fred Hutchinson Cancer Research Center
Dipanjan Chowdhury
Dipanjan Chowdhury Harvard University
Elizabeth M. Swisher
Elizabeth M. Swisher University of Washington
Eliezer M. Van Allen
Eliezer M. Van Allen Harvard University
Akiko Shimamura
Akiko Shimamura Harvard University
Gad Getz
Gad Getz Broad Institute
Scott J. Rodig
Scott J. Rodig Harvard University

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