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Biology and Biochemistry

D-Index
59
Citations
17919
World Ranking
12316
National Ranking
5272

Overview

Akiko Shimamura is affiliated with Harvard University in the United States. Their research primarily resides within the broad fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these domains, Shimamura's work extensively covers subfields such as Genetics, Hematology, Immunology, Molecular Biology, and Epidemiology.

Their research focuses on several main topics related to blood disorders and hematologic malignancies. These include Blood disorders and treatments, Acute Myeloid Leukemia Research, Immunodeficiency and Autoimmune Disorders, Hematopoietic Stem Cell Transplantation, Erythrocyte Function and Pathophysiology, Pneumocystis jirovecii pneumonia detection and treatment, and Myeloproliferative Neoplasms: Diagnosis and Treatment.

Shimamura has contributed to multiple publications, with frequent appearances in several scientific journals. The main venues for their work include Blood, Pediatric Blood & Cancer, Blood Advances, EJC Paediatric Oncology, and Experimental Hematology.

  • Blood
  • Pediatric Blood & Cancer
  • Blood Advances
  • EJC Paediatric Oncology
  • Experimental Hematology

They have collaborated regularly with a number of coauthors, which include Kasiani C. Myers, Taizo A. Nakano, Alison A. Bertuch, Edie Weller, and Elissa Furutani.

  • Kasiani C. Myers
  • Taizo A. Nakano
  • Alison A. Bertuch
  • Edie Weller
  • Elissa Furutani

Selected recent publications illustrate the scope of Shimamura's research:

  • International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data, 2022, Blood
  • On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology, 2020, Nature Biomedical Engineering
  • Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia, 2022, Blood
  • Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome, 2021, Nature Communications
  • MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia, 2020, Cell Stem Cell

Best Publications

  • Disease-Specific Induced Pluripotent Stem Cells

    In Hyun Park;Natasha Arora;Hongguang Huo;Nimet Maherali

  • Pathophysiology and management of inherited bone marrow failure syndromes

    Akiko Shimamura;Blanche P. Alter

  • Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference

    Adrianna Vlachos;Sarah Ball;Niklas Dahl;Blanche P. Alter

  • Rsk1 mediates a MEK–MAP kinase cell survival signal

    Akiko Shimamura;Bryan A. Ballif;Stephanie A. Richards;John Blenis

  • Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy

    Michael Y. Zhang;Jane E. Churpek;Siobán B. Keel;Tom Walsh

  • Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature

    Jan Kazenwadel;Genevieve A. Secker;Yajuan J. Liu;Jill A. Rosenfeld

  • Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy.

    Philip S. Rosenberg;Cornelia Zeidler;Audrey Anna Bolyard;Blanche P. Alter

  • Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood.

    Betsy Hirsch;Akiko Shimamura;Lisa Moreau;Shari Baldinger

  • Draft consensus guidelines for diagnosis and treatment of Shwachman-Diamond syndrome.

    Yigal Dror;Jean Donadieu;Jutta Koglmeier;John Dodge

  • Fanconi anemia pathway–deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated

    Richard D. Kennedy;Clark C. Chen;Patricia Stuckert;Elyse M. Archila

  • On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology.

    David B. Chou;David B. Chou;Viktoras Frismantas;Yuka Milton;Rhiannon David

  • Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies

    Maya Lewinsohn;Anna L. Brown;Anna L. Brown;Luke M Weinel;Luke M Weinel;Connie Phung

  • Genetic predisposition to hematologic malignancies: management and surveillance

    Lucy A. Godley;Akiko Shimamura

  • Shwachman-Diamond Syndrome: A Review of the Clinical Presentation, Molecular Pathogenesis, Diagnosis, and Treatment

    Lauri Burroughs;Ann Woolfrey;Ann Woolfrey;Akiko Shimamura;Akiko Shimamura

  • Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

    Stephanie A. Richards;Joyce Fu;Angela Romanelli;Akiko Shimamura

  • The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.

    Karthik A. Ganapathi;Karyn M. Austin;Chung Sheng Lee;Anusha Dias

  • Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts.

    Gaël McGill;Akiko Shimamura;Richard C. Bates;Robert E. Savage

  • Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L.

    Dong Hui Chen;Jennifer E. Below;Akiko Shimamura;Sioban B. Keel

  • Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway

    Jean Soulier;Thierry Leblanc;Jérôme Larghero;Hélène Dastot

  • The Shwachman-Diamond SBDS protein localizes to the nucleolus

    Karyn M. Austin;Rebecca J. Leary;Rebecca J. Leary;Akiko Shimamura;Akiko Shimamura

Frequent Co-Authors

David C. Dale
David C. Dale University of Washington
Peter E. Newburger
Peter E. Newburger University of Massachusetts Chan Medical School
Stella M. Davies
Stella M. Davies Cincinnati Children's Hospital Medical Center
Blanche P. Alter
Blanche P. Alter National Institutes of Health
Mark D. Fleming
Mark D. Fleming Boston Children's Hospital
Mary Claire King
Mary Claire King University of Washington
Laurence A. Boxer
Laurence A. Boxer University of Michigan–Ann Arbor
Alan D. D'Andrea
Alan D. D'Andrea Dana-Farber Cancer Institute
Daniel C. Link
Daniel C. Link Washington University in St. Louis
Tom Walsh
Tom Walsh University of Washington

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