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Molecular Biology

D-Index
120
Citations
84525
World Ranking
255
National Ranking
149

Overview

John Blenis is a researcher affiliated with Cornell University in the United States. Their primary field of study lies within Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology. Other notable subfields in their research include Cancer Research, Cell Biology, Physiology, and Epidemiology.

The main topics covered in John Blenis's work include Cancer, Hypoxia, and Metabolism; RNA modifications and cancer; PI3K/AKT/mTOR signaling in cancer; Epigenetics and DNA Methylation; Autophagy in Disease and Therapy; Calcium signaling and nucleotide metabolism; and Metabolomics and Mass Spectrometry Studies.

John Blenis's publication record features contributions to several journals and venues, with multiple papers published in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Cancer Research
  • Nature
  • Cell

Frequent co-authors in John Blenis's research collaborations include:

  • Lewis C. Cantley
  • Vivien Low
  • Noah Dephoure
  • Sungyun Cho
  • Gina Lee

Some of the recent published papers by John Blenis are:

  • "An atlas of substrate specificities for the human serine/threonine kinome," 2023, Nature
  • "Age-induced accumulation of methylmalonic acid promotes tumour progression," 2020, Nature
  • "mTORC1 promotes cell growth via m6A-dependent mRNA degradation," 2021, Molecular Cell
  • "The intrinsic substrate specificity of the human tyrosine kinome," 2024, Nature
  • "Altered propionate metabolism contributes to tumour progression and aggressiveness," 2022, Nature Metabolism

Best Publications

  • Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

    Anne Brunet;Azad Bonni;Michael J Zigmond;Michael Z Lin

  • ERK AND P38 MAPK-ACTIVATED PROTEIN KINASES: A FAMILY OF PROTEIN KINASES WITH DIVERSE BIOLOGICAL FUNCTIONS

    Philippe P. Roux;John Blenis

  • Molecular mechanisms of mTOR-mediated translational control

    Xiaoju Max Ma;John Blenis

  • The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

    Michelle C. Mendoza;E. Emrah Er;John Blenis

  • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

    Brendan D Manning;Brendan D Manning;Andrew R Tee;M.Nicole Logsdon;John Blenis

  • Signal transduction via the MAP kinases: proceed at your own RSK.

    John Blenis

  • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

    Diane C Fingar;John Blenis

  • Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

    Haiying Zhang;Daniela Freitas;Han Sang Kim;Han Sang Kim;Kristina Fabijanic

  • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

    Andrew R Tee;Brendan D Manning;Brendan D Manning;Philippe P Roux;Lewis C Cantley;Lewis C Cantley

  • Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

    Rey-Huei Chen;C. Sarnecki;J. Blenis

  • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.

    Jongkyeong Chung;Calvin J. Kuo;Gerald R. Crabtree;John Blenis

  • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

    B Cheatham;C J Vlahos;L Cheatham;L Wang

  • mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

    Marina K. Holz;Bryan A. Ballif;Steven P. Gygi;John Blenis

  • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

    Diane C. Fingar;Sofie Salama;Christina Tsou;Ed Harlow

  • Rapamycin: one drug, many effects

    Jing Li;Sang Gyun Kim;John Blenis

  • Molecular interpretation of ERK signal duration by immediate early gene products

    Leon O. Murphy;Sallie Smith;Rey Huei Chen;Diane C. Fingar

  • ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

    Kenneth W. Wood;Charlyn Sarnecki;Thomas M. Roberts;John Blenis

  • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.

    Diane C. Fingar;Celeste J. Richardson;Andrew R. Tee;Lynn Cheatham

  • Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos

    Sudhanshu Agrawal;Anshu Agrawal;Barbara Doughty;Andrew Gerwitz

  • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

    Andrew R. Tee;Diane C. Fingar;Brendan D. Manning;David J. Kwiatkowski

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
Philippe P. Roux
Philippe P. Roux University of Montreal
Steven P. Gygi
Steven P. Gygi Harvard University
Jongkyeong Chung
Jongkyeong Chung Seoul National University
Bryan A. Ballif
Bryan A. Ballif University of Vermont
Raymond L. Erikson
Raymond L. Erikson Harvard University
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Elizabeth P. Henske
Elizabeth P. Henske Harvard Medical School
Brendan D. Manning
Brendan D. Manning Harvard University

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