What is he best known for?
The fields of study he is best known for:
- Gene
- Phosphorylation
- Cancer
His main research concerns PI3K/AKT/mTOR pathway, Cell biology, RPTOR, RHEB and mTORC2.
His PI3K/AKT/mTOR pathway research incorporates themes from Protein kinase A and Phosphorylation.
His study brings together the fields of Autophagy and Cell biology.
In his research, Wnt signaling pathway, Hamartoma, Translation, Ribosomal s6 kinase and Initiation factor is intimately related to Cell growth, which falls under the overarching field of RPTOR.
He works mostly in the field of mTORC2, limiting it down to topics relating to TOR Serine-Threonine Kinases and, in certain cases, Protein kinase C, Signal transducing adaptor protein and Energy homeostasis.
His P70-S6 Kinase 1 study which covers Tuberous sclerosis protein that intersects with Cancer research and Peutz–Jeghers syndrome.
His most cited work include:
- Guidelines for the use and interpretation of assays for monitoring autophagy (3242 citations)
- TSC2 mediates cellular energy response to control cell growth and survival. (2963 citations)
- TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling (2383 citations)
What are the main themes of his work throughout his whole career to date?
Ken Inoki mainly focuses on Cell biology, PI3K/AKT/mTOR pathway, mTORC1, RHEB and Endocrinology.
His studies deal with areas such as Autophagy and Biochemistry as well as Cell biology.
His research in PI3K/AKT/mTOR pathway intersects with topics in Protein kinase B and Cell growth.
His mTORC1 study combines topics from a wide range of disciplines, such as Amino acid, Oxidative stress, Endocytosis and Podocyte.
He combines subjects such as GTPase, P70-S6 Kinase 1, TSC1 and Small GTPase with his study of RHEB.
His work on Eukaryotic initiation factor 4E binding as part of general P70-S6 Kinase 1 research is frequently linked to GTPase-activating protein, thereby connecting diverse disciplines of science.
He most often published in these fields:
- Cell biology (69.31%)
- PI3K/AKT/mTOR pathway (49.50%)
- mTORC1 (42.57%)
What were the highlights of his more recent work (between 2014-2021)?
- Cell biology (69.31%)
- mTORC1 (42.57%)
- PI3K/AKT/mTOR pathway (49.50%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Cell biology, mTORC1, PI3K/AKT/mTOR pathway, RHEB and Mechanistic target of rapamycin.
The concepts of his Cell biology study are interwoven with issues in Amino acid, Biochemistry, Knockout mouse and Transcription factor.
His mTORC1 research includes themes of Endocytosis and Kinase.
Particularly relevant to mTORC2 is his body of work in PI3K/AKT/mTOR pathway.
His study focuses on the intersection of Mechanistic target of rapamycin and fields such as Podocyte with connections in the field of Diabetic nephropathy, Bioinformatics, Phosphatidylinositol and Ragulator complex.
His research in the fields of AMPK overlaps with other disciplines such as Context.
Between 2014 and 2021, his most popular works were:
- LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs (87 citations)
- Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress. (60 citations)
- Growth factor signaling to mTORC1 by amino acid–laden macropinosomes (55 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Cancer
- Phosphorylation
His primary scientific interests are in Cell biology, mTORC1, Cell growth, Protein kinase A and RNA-binding protein.
His Cell biology research includes elements of Translation and T arm.
His mTORC1 research is multidisciplinary, relying on both AMPK and Muscle atrophy.
The Cell growth study combines topics in areas such as Signal transduction, Small GTPase, Endocytosis and RHEB.
His Protein kinase A research is multidisciplinary, incorporating elements of PI3K/AKT/mTOR pathway, Cell division, Saccharomyces cerevisiae and Downregulation and upregulation.
His research integrates issues of EIF4E, Ribosome profiling, Eukaryotic translation and Initiation factor in his study of RNA-binding protein.
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