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Biology and Biochemistry

D-Index
65
Citations
48146
World Ranking
8912
National Ranking
3958

Overview

Ken Inoki is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Within these fields, they focus notably on subfields such as Molecular Biology, Epidemiology, Physiology, Genetics, and Cell Biology.

The scientist's work covers several main topics, including:

  • Pancreatic function and diabetes
  • PI3K/AKT/mTOR signaling in cancer
  • Autophagy in Disease and Therapy
  • Metabolism, Diabetes, and Cancer
  • Adipose Tissue and Metabolism
  • Adipokines, Inflammation, and Metabolic Diseases
  • Renal Diseases and Glomerulopathies

Ken Inoki has contributed to multiple publications, frequently appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Blood, Journal of Cellular Physiology, Cell Reports, and the Journal of Clinical Investigation. Their recent papers include the following:

  • SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes, 2023, Journal of Clinical Investigation
  • Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases, 2022, Nature Reviews Nephrology
  • ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity, 2020, Blood
  • PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity, 2022, Molecular Biology of the Cell
  • Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity, 2020, Molecular Cell

Their work has involved collaboration with a number of frequent co-authors, including Sungki Hong, Swayam Prakash Srivastava, Ormond A. MacDougald, Vinamra Swaroop, and Lu Liu.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • TSC2 mediates cellular energy response to control cell growth and survival.

    Ken Inoki;Tianqing Zhu;Kun Liang Guan

  • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

    Ken Inoki;Yong Li;Tianquan Zhu;Jun Wu

  • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

    Ken Inoki;Yong Li;Tian Xu;Kun Liang Guan

  • TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

    Ken Inoki;Hongjiao Ouyang;Tianqing Zhu;Charlotta Lindvall

  • Dysregulation of the TSC-mTOR pathway in human disease.

    Ken Inoki;Michael N. Corradetti;Kun Liang Guan

  • AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

    Ken Inoki;Joungmok Kim;Kun Liang Guan

  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

    Angela Alexander;Sheng Li Cai;Jinhee Kim;Adrian Nanez

  • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

    Tsuneo Ikenoue;Ken Inoki;Qian Yang;Xiaoming Zhou

  • Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

    Michael N. Corradetti;Ken Inoki;Nabeel Bardeesy;Ronald A. DePinho

  • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

    Qian Yang;Ken Inoki;Tsuneo Ikenoue;Kun Liang Guan

  • mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

    Ken Inoki;Hiroyuki Mori;Junying Wang;Tsukasa Suzuki

  • Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

    Markus Gödel;Björn Hartleben;Nadja Herbach;Shuya Liu

  • Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

    Masako Narita;Andrew R. J. Young;Satoko Arakawa;Shamith A. Samarajiwa

  • TSC2: filling the GAP in the mTOR signaling pathway

    Yong Li;Michael N. Corradetti;Ken Inoki;Kun Liang Guan

  • Signaling by Target of Rapamycin Proteins in Cell Growth Control

    Ken Inoki;Hongjiao Ouyang;Yong Li;Kun Liang Guan;Kun Liang Guan

  • TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

    Huira Chong-Kopera;Ken Inoki;Yong Li;Tianqing Zhu

  • The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway

    Michael N. Corradetti;Ken Inoki;Kun Liang Guan

  • Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.

    Yong Li;Ken Inoki;Kun Liang Guan;Kun Liang Guan

Frequent Co-Authors

Kun-Liang Guan
Kun-Liang Guan Westlake University
Daisuke Koya
Daisuke Koya Kanazawa Medical University
Tobias B. Huber
Tobias B. Huber Universität Hamburg
Ormond A. MacDougald
Ormond A. MacDougald University of Michigan–Ann Arbor
Cheryl L. Walker
Cheryl L. Walker Baylor College of Medicine
Masashi Narita
Masashi Narita University of Cambridge
Sergio Lavandero
Sergio Lavandero University of Chile
Daniel J. Klionsky
Daniel J. Klionsky University of Michigan–Ann Arbor
Shigeomi Shimizu
Shigeomi Shimizu Tokyo Medical and Dental University
Mustafa Sahin
Mustafa Sahin Boston Children's Hospital

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