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Biology and Biochemistry

D-Index
78
Citations
63419
World Ranking
4425
National Ranking
291

Overview

Shigeomi Shimizu is affiliated with Tokyo Medical and Dental University in Japan. Their research spans multiple fields with a focus on Medicine and Biochemistry, Genetics and Molecular Biology. Key subfields include Molecular Biology, Epidemiology, Cell Biology, Physiology, and Neurology.

The scientist's work addresses several main topics, notably:

  • Autophagy in Disease and Therapy
  • Endoplasmic Reticulum Stress and Disease
  • Pancreatic function and diabetes
  • Parkinson's Disease Mechanisms and Treatments
  • Metabolism, Diabetes, and Cancer
  • Cellular transport and secretion
  • Calcium signaling and nucleotide metabolism

Shimizu has published extensively in frequent venues such as:

  • Nature Communications
  • Biochemical and Biophysical Research Communications
  • Cells
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports

Example recent papers include:

  • "Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy," 2020, Nature Communications
  • "Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration," 2020, Nature Communications
  • "ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue," 2020, Life Science Alliance
  • "Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation," 2021, Frontiers in Cell and Developmental Biology
  • "Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice," 2021, Human Molecular Genetics

Shimizu frequently collaborates with a group of co-authors, including:

  • Satoru Torii
  • Satoko Arakawa
  • Shinya Honda
  • Hirofumi Yamaguchi
  • Hajime Tajima Sakurai

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

    Shigeomi Shimizu;Masashi Narita;Yoshihide Tsujimoto

  • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

    Takashi Nakagawa;Shigeomi Shimizu;Tetsuya Watanabe;Osamu Yamaguchi

  • Intracellular ATP levels determine cell death fate by apoptosis or necrosis

    Yutaka Eguchi;Shigeomi Shimizu;Yoshihide Tsujimoto

  • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes.

    Shigeomi Shimizu;Toku Kanaseki;Noboru Mizushima;Noboru Mizushima;Noboru Mizushima;Takeshi Mizuta

  • Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

    Masashi Narita;Shigeomi Shimizu;Toshinori Ito;Thomas Chittenden

  • Discovery of Atg5/Atg7-independent alternative macroautophagy

    Yuya Nishida;Satoko Arakawa;Kenji Fujitani;Hirofumi Yamaguchi

  • Autophagy mediates the mitotic senescence transition

    Andrew R.J. Young;Masako Narita;Manuela Ferreira;Kristina Kirschner

  • Another way to die: autophagic programmed cell death

    Y Tsujimoto;S Shimizu

  • Bcl-2 family: Life-or-death switch

    Yoshihide Tsujimoto;Shigeomi Shimizu

  • Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

    Shigeomi Shimizu;Yutaka Eguchi;Hiroaki Kosaka;Wataru Kamiike

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Role of the mitochondrial membrane permeability transition in cell death.

    Yoshihide Tsujimoto;Shigeomi Shimizu

  • JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

    Fuminori Tsuruta;Jun Sunayama;Yasunori Mori;Seisuke Hattori

  • BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death.

    Shigeomi Shimizu;Akimitsu Konishi;Takashi Kodama;Yoshihide Tsujimoto

  • Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene.

    S. Shibahara;Y. Morimoto;Y. Furutani;M. Notake

  • Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

    Masako Narita;Andrew R. J. Young;Satoko Arakawa;Shamith A. Samarajiwa

  • Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

    Shigeomi Shimizu;Yosuke Matsuoka;Yasuo Shinohara;Yoshihiro Yoneda

Frequent Co-Authors

Yoshihide Tsujimoto
Yoshihide Tsujimoto Osaka University
Hikaru Matsuda
Hikaru Matsuda Osaka University
Masashi Narita
Masashi Narita University of Cambridge
Yasuo Uchiyama
Yasuo Uchiyama Juntendo University
Kinya Otsu
Kinya Otsu King's College London
Sergio Lavandero
Sergio Lavandero University of Chile
Noboru Mizushima
Noboru Mizushima University of Tokyo
Tatsuya Saitoh
Tatsuya Saitoh Osaka University
Masaaki Komatsu
Masaaki Komatsu Juntendo University
Evelina Gatti
Evelina Gatti Aix-Marseille University

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