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Neuroscience

D-Index
54
Citations
16001
World Ranking
4845
National Ranking
2180

Overview

Kimberly M. Huber is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily spans Biochemistry, Genetics and Molecular Biology, with notable contributions to Neuroscience. The subfields of study include Genetics, Molecular Biology, Cognitive Neuroscience, Cellular and Molecular Neuroscience, and Cell Biology.

The central themes of Huber's work focus on Genetics and Neurodevelopmental Disorders, Autism Spectrum Disorder Research, Neuroscience and Neuropharmacology Research, Pancreatic function and diabetes, RNA modifications and cancer, RNA and protein synthesis mechanisms, and Congenital heart defects research.

Huber has published extensively in several scientific venues. Frequent publication locations include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurobiology of Disease
  • Cell Reports
  • Frontiers in Synaptic Neuroscience
  • Science Translational Medicine

Notable recent papers by Huber encompass the following:

  • "FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism" (2020, Cell Reports)
  • "Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome" (2020, Science Translational Medicine)
  • "Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome" (2023, Neuron)
  • "Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP" (2020, Molecular Autism)
  • "Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP" (2021, eLife)

Collaborative efforts characterize a significant portion of Huber's research activity. Frequent coauthors include:

  • Jay R. Gibson
  • Gemma Molinaro
  • Khaleel A. Razak
  • Shari G. Birnbaum
  • Zhe Zhang

Best Publications

  • The mGluR theory of fragile X mental retardation

    Mark F Bear;Kimberly M Huber;Stephen T Warren

  • Altered synaptic plasticity in a mouse model of fragile X mental retardation

    Kimberly M. Huber;Kimberly M. Huber;Sean M. Gallagher;Stephen T. Warren;Mark F. Bear

  • Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

    Kimberly M. Huber;Matthew S. Kayser;Mark F. Bear

  • Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

    Christian Lüscher;Kimberly M. Huber

  • Internalization of ionotropic glutamate receptors in response to mGluR activation.

    Eric M. Snyder;Benjamin D. Philpot;Kimberly M. Huber;Xin Dong

  • Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

    Jay R. Gibson;Aundrea F. Bartley;Seth A. Hays;Kimberly M. Huber

  • Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

    Maggie W. Waung;Brad E. Pfeiffer;Elena D. Nosyreva;Jennifer A. Ronesi

  • Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

    Kimberly M. Huber;John C. Roder;Mark F. Bear

  • Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome

    Elena D. Nosyreva;Kimberly M. Huber

  • Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

    Meng Lu Liu;Tong Zang;Yuhua Zou;Joshua C. Chang

  • Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

    Nien Pei Tsai;Julia R. Wilkerson;Weirui Guo;Marina A. Maksimova

  • Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation.

    Jennifer A. Ronesi;Kimberly M. Huber

  • Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

    Sean M. Gallagher;Christine A. Daly;Mark F. Bear;Kimberly M. Huber

  • Brain cholesterol turnover required for geranylgeraniol production and learning in mice

    Tiina J. Kotti;Denise M. O. Ramirez;Brad E. Pfeiffer;Kimberly M. Huber

  • Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

    Jennifer A. Ronesi;Katie A. Collins;Seth A. Hays;Nien Pei Tsai

  • PLC-β1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex

    Anthony J. Hannan;Colin Blakemore;Alla Katsnelson;Tania Vitalis

  • Developmental Switch in Synaptic Mechanisms of Hippocampal Metabotropic Glutamate Receptor-Dependent Long-Term Depression

    Elena D. Nosyreva;Kimberly M. Huber

  • The State of Synapses in Fragile X Syndrome

    Brad E. Pfeiffer;Kimberly M. Huber

  • Neuroligin-2 Deletion Selectively Decreases Inhibitory Synaptic Transmission Originating from Fast-Spiking but Not from Somatostatin-Positive Interneurons

    Jay R. Gibson;Kimberly M. Huber;Thomas C. Südhof;Thomas C. Südhof

  • MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.

    Adam J Harrington;Adam J Harrington;Aram Raissi;Kacey Rajkovich;Stefano Berto

  • Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression

    Lenora J. Volk;Christine A. Daly;Kimberly M. Huber

Frequent Co-Authors

Stephen T. Warren
Stephen T. Warren Emory University
Seth A. Hays
Seth A. Hays The University of Texas at Dallas
Shari G. Birnbaum
Shari G. Birnbaum The University of Texas Southwestern Medical Center
Shannon L. Gourley
Shannon L. Gourley Emory University
Peter C. Kind
Peter C. Kind University of Edinburgh
Michael Q. Zhang
Michael Q. Zhang The University of Texas at Dallas
Hongkui Zeng
Hongkui Zeng Allen Institute for Brain Science
Paul F. Worley
Paul F. Worley Johns Hopkins University School of Medicine
Eric Klann
Eric Klann New York University

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