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Biology and Biochemistry

D-Index
96
Citations
62321
World Ranking
1785
National Ranking
985

Overview

Roberta A. Gottlieb is affiliated with Cedars-Sinai Medical Center in the United States and has contributed extensively to research in the fields of medicine and biochemistry, genetics, and molecular biology. Their work spans multiple specialized subfields, including molecular biology, epidemiology, surgery, cardiology and cardiovascular medicine, and physiology.

The research topics that Roberta A. Gottlieb focuses on include autophagy in disease and therapy, mitochondrial function and pathology, pancreatic function and diabetes, adipose tissue and metabolism, endoplasmic reticulum stress and disease, cardiovascular function and risk factors, and metabolism and genetic disorders.

Notable recent papers authored or coauthored by Roberta A. Gottlieb include:

  • Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis, 2021, JCI Insight
  • At the heart of mitochondrial quality control: many roads to the top, 2021, Cellular and Molecular Life Sciences
  • Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation, 2020, Proceedings of the National Academy of Sciences
  • DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress, 2023, Nature Communications
  • Attenuation of Adverse Postinfarction Left Ventricular Remodeling with Empagliflozin Enhances Mitochondria-Linked Cellular Energetics and Mitochondrial Biogenesis, 2021, International Journal of Molecular Sciences

Frequent coauthors in their research collaborations include:

  • Aleksandr Stotland
  • Jennifer E. Van Eyk
  • D. Taylor
  • Allen M. Andres
  • Honit Piplani

Roberta A. Gottlieb's work is published often in scientific venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • International Journal of Molecular Sciences
  • Journal of Molecular and Cellular Cardiology
  • Frontiers in Physiology

Their research primarily addresses complex biological processes with an emphasis on mitochondrial quality control, autophagy, cardiovascular inflammation, ischemic and hypoxic cellular stress, and cellular energetics related to mitochondrial biogenesis.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

    Christopher P. Baines;Robert A. Kaiser;Nicole H. Purcell;N. Scott Blair

  • Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

    Roberta A. Gottlieb;Katharine O. Burleson;Robert A. Kloner;Bernard M. Babior

  • The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases.

    Yoram Devary;Roberta A. Gottlieb;Tod Smeal;Michael Karin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Rapid and preferential activation of the c-jun gene during the mammalian UV response.

    Yoram Devary;Roberta A. Gottlieb;Lester F. Lau;Michael Karin

  • Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.

    A. Hamacher-Brady;Nathan R. Brady;S. E. Logue;M. R. Sayen

  • Enhancing Macroautophagy Protects against Ischemia/Reperfusion Injury in Cardiac Myocytes

    Anne Hamacher-Brady;Nathan R. Brady;Roberta A. Gottlieb

  • Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification

    Roberta A. Gottlieb;Judy Nordberg;Evan Skowronski;Bernard M. Babior

  • Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

    Jean Ehrland Ricci;Roberta A. Gottlieb;Douglas R. Green

  • New Paradigm for Lymphocyte Granule-mediated Cytotoxicity: TARGET CELLS BIND AND INTERNALIZE GRANZYME B, BUT AN ENDOSOMOLYTIC AGENT IS NECESSARY FOR CYTOSOLIC DELIVERY AND SUBSEQUENT APOPTOSIS *

    Christopher J. Froelich;Kim A Orth;Jane Turbov;Prem Seth

  • Heart mitochondria: gates of life and death

    Asa B. Gustafsson;Roberta A. Gottlieb

  • Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion.

    Min Chen;Huaping He;Shixing Zhan;Stan Krajewski

  • Autophagy in Ischemic Heart Disease

    Åsa B. Gustafsson;Roberta A. Gottlieb

  • Bcl-2 family members and apoptosis, taken to heart.

    Åsa B. Gustafsson;Roberta A. Gottlieb

  • Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

    Chengqun Huang;Allen M. Andres;Eric P. Ratliff;Genaro Hernandez

  • Calpain and Mitochondria in Ischemia/Reperfusion Injury

    Min Chen;Dong-Jun Won;Stan Krajewski;Roberta A. Gottlieb

Frequent Co-Authors

Åsa B. Gustafsson
Åsa B. Gustafsson University of California, San Diego
Bernard M. Babior
Bernard M. Babior Scripps Research Institute
David J. Granville
David J. Granville University of British Columbia
Jennifer E. Van Eyk
Jennifer E. Van Eyk Cedars-Sinai Medical Center
Sergio Lavandero
Sergio Lavandero University of Chile
Kelly S. Doran
Kelly S. Doran University of Colorado Denver
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Evelina Gatti
Evelina Gatti Aix-Marseille University
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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