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Biology and Biochemistry

D-Index
64
Citations
17057
World Ranking
9546
National Ranking
4214

Overview

Edward J. Lesnefsky is affiliated with Virginia Commonwealth University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Pathology and Forensic Medicine, Surgery, Cell Biology, and Physiology.

The scientist's work focuses on several main topics, including:

  • Mitochondrial Function and Pathology
  • Cardiac Ischemia and Reperfusion
  • Endoplasmic Reticulum Stress and Disease
  • Transplantation: Methods and Outcomes
  • Calpain Protease Function and Regulation
  • Organ Transplantation Techniques and Outcomes
  • Spinal Cord Injury Research

Their recent published papers illustrate these thematic areas and include the following:

  • "Leigh Syndrome: A Tale of Two Genomes," 2021, Frontiers in Physiology
  • "Endoplasmic reticulum stress-mediated mitochondrial dysfunction in aged hearts," 2020, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • "Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload," 2020, Archives of Biochemistry and Biophysics
  • "Sixteen weeks of testosterone with or without evoked resistance training on protein expression, fiber hypertrophy and mitochondrial health after spinal cord injury," 2020, Journal of Applied Physiology
  • "Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function," 2021, Aging

Edward J. Lesnefsky frequently publishes in the following venues:

  • Circulation
  • Frontiers in Physiology
  • Translational Research
  • Cells
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

The scientist collaborates extensively, with frequent co-authors including:

  • Qun Chen
  • Jeremy Thompson
  • Ying Hu
  • Mohammed Quader
  • Stefano Toldo

Overall, the research outputs and collaborations of Edward J. Lesnefsky contribute to understanding mitochondrial biology, cardiac health, and cellular stress mechanisms, particularly in the context of aging, ischemia-reperfusion injury, and spinal cord injury.

Best Publications

  • Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III *

    Qun Chen;Qun Chen;Edwin J. Vazquez;Shadi Moghaddas;Charles L. Hoppel;Charles L. Hoppel

  • Function of Mitochondrial Stat3 in Cellular Respiration

    Joanna Wegrzyn;Ramesh Potla;Yong Joon Chwae;Naresh B.V. Sepuri

  • Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure.

    Edward J. Lesnefsky;Edward J. Lesnefsky;Shadi Moghaddas;Bernard Tandler;Janos Kerner

  • Intracoronary ultrasound imaging: Correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty

    John McB. Hodgson;Karan G. Reddy;Randeep Suneja;Ravi N. Nair

  • Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

    Graham M. Strub;Melanie Paillard;Jie Liang;Ludovic Gomez

  • Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

    Qun Chen;Shadi Moghaddas;Charles L. Hoppel;Edward J. Lesnefsky

  • Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies

    Edward J. Lesnefsky;Edward J. Lesnefsky;Qun Chen;Bernard Tandler;Charles L. Hoppel

  • Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion

    Qun Chen;Amadou K. S. Camara;David F. Stowe;David F. Stowe;David F. Stowe;Charles L. Hoppel

  • Mitochondrial Metabolism in Aging Heart.

    Edward J. Lesnefsky;Qun Chen;Charles L. Hoppel

  • Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria

    Edward J. Lesnefsky;Bernaed Tandler;Jian Ye;Thomas J. Slabe

  • Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria.

    Stephen W. Fannin;Edward J. Lesnefsky;Thomas J. Slabe;Mehat O. Hassan

  • Blockade of electron transport during ischemia protects cardiac mitochondria.

    Edward J. Lesnefsky;Qun Chen;Shadi Moghaddas;Medhat O. Hassan

  • Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion.

    Qun Chen;Shadi Moghaddas;Charles L. Hoppel;Edward J. Lesnefsky

  • Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria

    Edward J. Lesnefsky;Thomas J. Slabe;Maria S. K. Stoll;Paul E. Minkler

  • Potential therapeutic benefits of strategies directed to mitochondria.

    Amadou K.S. Camara;Edward J. Lesnefsky;Edward J. Lesnefsky;David F. Stowe

  • Oxidative phosphorylation and aging.

    Edward J. Lesnefsky;Charles L. Hoppel

  • Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial)

    Benjamin W. Van Tassell;Justin Canada;Salvatore Carbone;Cory Trankle

  • Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy.

    Jose F. Huizar;Karoly Kaszala;Jonathan Potfay;Anthony J. Minisi

  • Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III.

    Edward J. Lesnefsky;Tatyana I. Gudz;Catharina T. Migita;Masao Ikeda-Saito

  • Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

    Karol Szczepanek;Qun Chen;Marta Derecka;Marta Derecka;Fadi N. Salloum

Frequent Co-Authors

Charles L. Hoppel
Charles L. Hoppel Case Western Reserve University
Bernard Tandler
Bernard Tandler Case Western Reserve University
Andrew C. Larner
Andrew C. Larner Virginia Commonwealth University
David F. Stowe
David F. Stowe Medical College of Wisconsin
Rakesh C. Kukreja
Rakesh C. Kukreja Virginia Commonwealth University
Jeremy C. Allegood
Jeremy C. Allegood Virginia Commonwealth University
John J. Mieyal
John J. Mieyal Case Western Reserve University
Antonio Abbate
Antonio Abbate University of Virginia
Hisashi Fujioka
Hisashi Fujioka Case Western Reserve University
Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University

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