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Medicine

D-Index
78
Citations
17859
World Ranking
18193
National Ranking
9071

Overview

Rakesh C. Kukreja is affiliated with Virginia Commonwealth University in the United States and has a research focus primarily in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple fields of study including cardiology and cardiovascular medicine, molecular biology, pulmonary and respiratory medicine, physiology, and oncology.

The scientist's research topics cover a range of specialized areas such as phosphodiesterase function and regulation, chemotherapy-induced cardiotoxicity and mitigation, prostate cancer treatment and research, sexual function and dysfunction studies, renin-angiotensin system studies, erythrocyte function and pathophysiology, and cellular processes involving caveolin-1.

Frequent collaborators include Arun Samidurai, Anindita Das, Lei Xi, Donatas Kraskauskas, and Surinder K. Batra.

Common publication venues where their research appears often include Circulation, Molecular and Cellular Biochemistry, The FASEB Journal, Journal of Ovarian Research, and The Annual Review of Pharmacology and Toxicology.

Representative recent research papers by Rakesh C. Kukreja include:

  • Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders, 2022, The Annual Review of Pharmacology and Toxicology
  • Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities, 2021, Pharmacology & Therapeutics
  • Cardiovascular risks and toxicity - The Achilles heel of androgen deprivation therapy in prostate cancer patients, 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout Mice, 2020, Scientific Reports
  • Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling, 2020, Clinical Cancer Research

Best Publications

  • PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

    Rakesh C. Kukreja;Hermes A. Kontos;Michael L. Hess;Earl F. Ellis

  • The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection

    Rakesh C Kukreja;Michael L Hess

  • Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

    Anindita Das;Lei Xi;Rakesh C. Kukreja

  • Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity

    Patrick W. Fisher;Fadi Salloum;Anindita Das;Haroon Hyder

  • Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

    Antonio Abbate;Fadi N. Salloum;Elena Vecile;Anindita Das

  • Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial KATP channels in rabbits

    Ramzi Ockaili;Fadi Salloum;John Hawkins;Rakesh C. Kukreja

  • Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis

    Liang Qiao;Elaine Studer;Kevin Leach;Robert McKinstry

  • Sildenafil Induces Delayed Preconditioning Through Inducible Nitric Oxide Synthase–Dependent Pathway in Mouse Heart

    Fadi Salloum;Chang Yin;Lei Xi;Rakesh C. Kukreja

  • HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

    Ramzi Ockaili;Ramesh Natarajan;Fadi Salloum;Bernard J. Fisher

  • Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications.

    Rakesh C. Kukreja;Fadi Salloum;Anindita Das;Ramzi Ockaili

  • A Novel Role of MicroRNA in Late Preconditioning: Upregulation of Endothelial Nitric Oxide Synthase and Heat Shock Protein 70

    Chang Yin;Fadi N. Salloum;Rakesh C. Kukreja

  • Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea.

    R Bolli;W X Zhu;C J Hartley;L H Michael

  • PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer.

    Anindita Das;David Durrant;Fadi N. Salloum;Lei Xi

  • Hypoxia Inducible Factor-1 Activation by Prolyl 4-Hydroxylase-2 Gene Silencing Attenuates Myocardial Ischemia Reperfusion Injury

    Ramesh Natarajan;Fadi N. Salloum;Bernard J. Fisher;Rakesh C. Kukreja

  • Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

    Fadi N. Salloum;Antonio Abbate;Anindita Das;Jon-Erik Houser

  • Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

    Anindita Das;Lei Xi;Rakesh C. Kukreja

  • The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.

    Steven P. Jones;Xian Liang Tang;Yiru Guo;Charles Steenbergen

  • Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.

    Tingcun Zhao;Lei Xi;Jeya Chelliah;Joseph E. Levasseur

  • Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes.

    Shakil A. Khan;Fadi Salloum;Anindita Das;Lei Xi

  • Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

    Karol Szczepanek;Qun Chen;Marta Derecka;Marta Derecka;Fadi N. Salloum

Frequent Co-Authors

Antonio Abbate
Antonio Abbate University of Virginia
Edward J. Lesnefsky
Edward J. Lesnefsky Virginia Commonwealth University
Surinder K. Batra
Surinder K. Batra University of Nebraska Medical Center
Roberto Bolli
Roberto Bolli University of Louisville
Paul Dent
Paul Dent Virginia Commonwealth University
Alfonso Baldi
Alfonso Baldi University of Campania "Luigi Vanvitelli"
Giuseppe Biondi-Zoccai
Giuseppe Biondi-Zoccai Sapienza University of Rome
Charles Steenbergen
Charles Steenbergen Johns Hopkins University
David J. Lefer
David J. Lefer Louisiana State University Health Sciences Center New Orleans
Steven Grant
Steven Grant Virginia Commonwealth University

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