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Medicine

D-Index
107
Citations
39568
World Ranking
6293
National Ranking
3356

Overview

James M. Downey is affiliated with the University of South Alabama in the United States. Their research spans multiple fields, including Medicine, Biochemistry, Genetics and Molecular Biology, and Engineering. The scientist's work has a multi-disciplinary focus that integrates biological sciences with engineering principles.

Downey's publications cover topics in molecular biology, aerospace engineering, pathology and forensic medicine, emergency medicine, and electrical and electronic engineering. Their primary research interests are reflected in the following main topics:

  • Cardiac Ischemia and Reperfusion
  • Cardiac Arrest and Resuscitation
  • Antenna Design and Analysis
  • Microwave Engineering and Waveguides
  • Mitochondrial Function and Pathology
  • Advanced Antenna and Metasurface Technologies
  • Inflammasome and immune disorders

Frequent collaboration is a characteristic of Downey's research approach, with notable co-authors including Michael V. Cohen, Xi-Ming Yang, Jonathon P. Audia, Bryan L. Schoenholz, and Sean M. Davidson.

Downey has contributed to multiple publication venues, highlighting a varied research footprint. These venues include:

  • IEEE Transactions on Antennas and Propagation
  • International Journal of Molecular Sciences
  • Circulation
  • IET Conference Proceedings
  • Redox Biology

Recent papers authored or co-authored by Downey feature studies in both biomedical and engineering disciplines:

  • Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection, 2023, Redox Biology
  • A Flat-Panel 8 × 8 Wideband K-/Ka-Band Dual Circularly Polarized Phased Array Antenna for CubeSat Communications, 2023, IEEE Transactions on Antennas and Propagation
  • The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart, 2021, Journal of Cardiovascular Pharmacology and Therapeutics
  • A 22-28 GHz Polarization-Reconfigurable Flat-Panel 8 × 8 Tx/Rx Phased Array Antenna With Uniquely Arranged Novel Radiating Elements for CubeSat Communication, 2023, IEEE Transactions on Antennas and Propagation
  • Dissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada, 2020, Scientific Reports

Best Publications

  • Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

    G. S. Liu;J. Thornton;D. M. Van Winkle;A. W. H. Stanley

  • Preconditioning the Myocardium: From Cellular Physiology to Clinical Cardiology

    Derek M. Yellon;James M. Downey

  • Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.

    Tilley Pain;Xi Ming Yang;Stuart D. Critz;Yankun Yue

  • Xanthine oxidase as a source of free radical damage in myocardial ischemia.

    David E. Chambers;Dale A. Parks;Guy Patterson;Ranjan Roy

  • Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways

    Xi-Ming Yang;J. Bradley Proctor;Lin Cui;Thomas Krieg

  • Preconditioning protects ischemic rabbit heart by protein kinase C activation.

    K. Ytrehus;Yongge Liu;J. M. Downey

  • Ischemic Preconditioning: From Adenosine Receptor to KATP Channel

    Michael V. Cohen;Christopher P. Baines;James M. Downey

  • Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

    Mahiko Goto;Yongge Liu;Xi-Ming Yang;Jeffrey L. Ardell

  • Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

    Christopher P. Baines;Mahiko Goto;James M. Downey

  • Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction.

    J D Thornton;G S Liu;R A Olsson;J M Downey

  • Ischemic preconditioning protects against infarction in rat heart.

    Yongge Liu;J. M. Downey

  • Preconditioning: state of the art myocardial protection.

    Clive S Lawson;James M Downey

  • Volatile anesthetics protect the ischemic rabbit myocardium from infarction.

    D K Cope;W K Impastato;M V Cohen;J M Downey

  • Inhibition of coronary blood flow by a vascular waterfall mechanism.

    James M. Downey;Edward S. Kirk

  • Signaling pathways in ischemic preconditioning

    James M. Downey;Amanda M. Davis;Michael V. Cohen

  • Preconditioning causes improved wall motion as well as smaller infarcts after transient coronary occlusion in rabbits.

    M V Cohen;G S Liu;J M Downey

  • Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels.

    Michael V. Cohen;Xi-Ming Yang;Guang S. Liu;Gerd Heusch

  • The pH Hypothesis of Postconditioning Staccato Reperfusion Reintroduces Oxygen and Perpetuates Myocardial Acidosis

    Michael V. Cohen;Xi-Ming Yang;James M. Downey

  • Signal transduction of ischemic preconditioning.

    Rainer Schulz;Michael V Cohen;Matthias Behrends;James M Downey

  • Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation.

    Xi-Ming Yang;Sebastian Philipp;James M. Downey;Michael V. Cohen

Frequent Co-Authors

Michael V. Cohen
Michael V. Cohen University of South Alabama
Derek M. Yellon
Derek M. Yellon University College London
Thomas Krieg
Thomas Krieg University of Cambridge
Gerd Heusch
Gerd Heusch University of Duisburg-Essen
David J. Hearse
David J. Hearse St Thomas' Hospital
Sean M. Davidson
Sean M. Davidson University College London
Michel Ovize
Michel Ovize Inserm : Institut national de la santé et de la recherche médicale
Rainer Schulz
Rainer Schulz University of Giessen
Narendra N. Tandon
Narendra N. Tandon Cellphire Therapeutics
Michael X Cohen
Michael X Cohen Radboud University

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