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Michael B. Wheeler

Michael B. Wheeler

D-Index & Metrics

Medicine

D-Index
86
Citations
21231
World Ranking
14306
National Ranking
598

Overview

Michael B. Wheeler is affiliated with the University of Toronto in Canada and has published extensively in the fields of medicine and biochemistry, genetics, and molecular biology. Their research addresses multiple facets of pancreatic function, diabetes, and metabolic processes, with a strong focus on gestational diabetes and its progression.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

The subfields highlighted in their work are:

  • Surgery
  • Obstetrics and Gynecology
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Genetics

Key topics addressed by Michael B. Wheeler comprise:

  • Pancreatic function and diabetes
  • Gestational Diabetes Research and Management
  • Birth, Development, and Health
  • Pregnancy and preeclampsia studies
  • Diet, Metabolism, and Disease
  • Diet and metabolism studies
  • Diabetes Management and Research

Their frequent co-authors have included:

  • Erica P. Gunderson
  • Feihan F. Dai
  • Anthony Piro
  • Saifur R. Khan
  • Stacey Alexeeff

Publication venues frequently featuring their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience
  • JCI Insight
  • Endocrinology
  • Diabetes

Among their recent papers are:

  • Amino acid and lipid metabolism in post-gestational diabetes and progression to type 2 diabetes: A metabolic profiling study (2020, PLoS Medicine)
  • Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake (2022, Cell & Bioscience)
  • Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α (2020, Journal of Clinical Investigation)
  • Integration of AI and traditional medicine in drug discovery (2021, Drug Discovery Today)
  • Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts (2023, Nature Biomedical Engineering)

Best Publications

  • Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

    Chen-Yu Zhang;György Baffy;György Baffy;Pascale Perret;Stefan Krauss

  • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

    Raewyn M Seaberg;Simon R Smukler;Timothy J Kieffer;Grigori Enikolopov

  • The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.

    Patrick E. MacDonald;Wasim El-kholy;Michael J. Riedel;Anne Marie F. Salapatek

  • Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion: Mechanism of Action

    Catherine B. Chan;Domenica De Leo;Jamie W. Joseph;Timothy S. McQuaid

  • Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

    M. Cristina Nostro;Farida Sarangi;Shinichiro Ogawa;Audrey Holtzinger

  • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

    Tamara J. Nicolson;Elisa A. Bellomo;Nadeeja Wijesekara;Merewyn K. Loder

  • Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells

    Guoxin Kang;Jamie W. Joseph;Oleg G. Chepurny;Marie Monaco

  • Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

    N. Wijesekara;F. F. Dai;A. B. Hardy;P. R. Giglou

  • Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

    Elaine Xu;Elaine Xu;Mohan Kumar;Mohan Kumar;Yi Zhang;Yi Zhang;William Ju;William Ju

  • Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

    Catherine B. Chan;Patrick E. MacDonald;Monique C. Saleh;David C. Johns

  • Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

    M. B. Wheeler;Ming Lu;J. S. Dillon;Xing-Hong Leng

  • Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

    P. E. MacDonald;M. B. Wheeler

  • Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

    Jamie W. Joseph;Vasilij Koshkin;Chen-Yu Zhang;Jing Wang

  • Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion,

    Nadeeja Wijesekara;Mansa Krishnamurthy;Alpana Bhattacharjee;Aamir Suhail

  • Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

    Jamie W. Joseph;Vasilij Koshkin;Monique C. Saleh;William I. Sivitz

  • Free Fatty Acid-Induced Reduction in Glucose Stimulated Insulin Secretion–Evidence for a Role of Oxidative Stress In Vitro and In Vivo

    Andrei I. Oprescu;George Bikopoulos;Anthony Naassan;Emma M. Allister

  • The adult mouse and human pancreas contain rare multipotent stem cells that express insulin.

    Simon R. Smukler;Margot E. Arntfield;Rozita Razavi;George Bikopoulos

  • Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

    M B Wheeler;L Sheu;M Ghai;A Bouquillon

  • The Identification of Potential Factors Associated with the Development of Type 2 Diabetes A Quantitative Proteomics Approach

    Hongfang Lu;Ying Yang;Emma M. Allister;Nadeeja Wijesekara

  • Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

    Hongfang Lu;Vasilij Koshkin;Emma M. Allister;Armen V. Gyulkhandanyan

Frequent Co-Authors

Herbert Y. Gaisano
Herbert Y. Gaisano University of Toronto
Denise D. Belsham
Denise D. Belsham University of Toronto
Gordon Keller
Gordon Keller University of Toronto
Gary Sweeney
Gary Sweeney York University
Guy A. Rutter
Guy A. Rutter Imperial College London
Orian S. Shirihai
Orian S. Shirihai University of California, Los Angeles
Patricia L. Brubaker
Patricia L. Brubaker University of Toronto
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center
David M. Irwin
David M. Irwin University of Toronto
Philippe Froguel
Philippe Froguel Imperial College London

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