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Claes B. Wollheim

Claes B. Wollheim

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
119
Citations
43557
World Ranking
682
National Ranking
16

Medicine

D-Index
119
Citations
43654
World Ranking
3937
National Ranking
49

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 1991 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Claes B. Wollheim is affiliated with the University of Geneva in Switzerland. Their research predominantly focuses on Medicine, with extensive contributions in Biochemistry, Genetics, and Molecular Biology. The subfields of study detailed in their work include Surgery, Molecular Biology, Endocrinology, Diabetes and Metabolism, Epidemiology, and Physiology.

The main topics covered in Wollheim's research relate significantly to pancreatic function and diabetes. Other prominent themes include metabolism in the context of diabetes and cancer, autophagy in disease and therapy, adipose tissue and metabolism, diabetes treatment and management, endoplasmic reticulum stress and disease, as well as diet, metabolism, and disease.

Their recent notable papers include:

  • "Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk" (2021, FEBS Journal)
  • "Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors" (2021, Translational Psychiatry)
  • "Elevated circulating follistatin associates with an increased risk of type 2 diabetes" (2021, Nature Communications)
  • "Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells" (2020, Diabetes)
  • "Islet Gene View-a tool to facilitate islet research" (2022, Life Science Alliance)

Wollheim frequently collaborates with several researchers, including Andreas Wiederkehr, Erik Renström, Kyu-Sang Park, Emma Ahlqvist, and Leif Groop.

Their research has been published in various venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Experimental & Molecular Medicine, FEBS Journal, Translational Psychiatry, and Nature Communications.

Wollheim's professional recognition includes being named a Member of Academia Europaea in 1991 and election as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

    M. Asfari;D. Janjic;Paolo Meda;Guodong Li

  • Regulation of insulin release by calcium.

    Claes Wollheim;G W Sharp

  • Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.

    Jesper Gromada;Isobel Franklin;Claes B. Wollheim

  • Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells

    Arnaud Merglen;Sten Theander;Blanca Rubi;Gaelle Chaffard

  • Mitochondrial function in normal and diabetic beta-cells.

    Pierre Maechler;Claes B. Wollheim

  • Is cytosolic ionized calcium regulating neutrophil activation

    Tullio Pozzan;Daniel P. Lew;Claes B. Wollheim;Roger Y. Tsien

  • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

    Pierre Maechler;Claes B. Wollheim

  • Islet |[beta]|-cell secretion determines glucagon release from neighbouring |[alpha]|-cells

    Hisamitsu Ishihara;Pierre Maechler;Asllan Gjinovci;Pedro-Luis Herrera

  • Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing

    N Sekine;V Cirulli;R Regazzi;L J Brown

  • Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

    Tasnim Dayeh;Petr Volkov;Sofia Salö;Elin Hall

  • Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

    João Fadista;Petter Vikman;Emilia Ottosson Laakso;Inês Guerra Mollet

  • Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

    M Prentki;T J Biden;D Janjic;R F Irvine

  • Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials.

    Werner Schlegel;Benoît P. Winiger;Patrice Mollard;Patrice Mollard;Pierre Vacher

  • Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

    Pierre Maechler;Lan Jornot;Claes B. Wollheim

  • β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

    Isobel Franklin;Jesper Gromada;Asllan Gjinovci;Sten Theander

  • A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.

    Jalal Taneera;Stefan Lang;Amitabh Sharma;Amitabh Sharma;Joao Fadista

  • Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.

    Magalie A. Ravier;Martin Güldenagel;Anne Charollais;Asllan Gjinovci

  • ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

    Haiyan Wang;Georgia Kouri;Claes B. Wollheim

  • Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.

    P D Lew;C B Wollheim;F A Waldvogel;T Pozzan

  • Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

    Jocelyne E. Kaufmann;Alexander Oksche;Claes B. Wollheim;Gabriele Günther

Frequent Co-Authors

Pierre Maechler
Pierre Maechler University of Geneva
Romano Regazzi
Romano Regazzi University of Lausanne
Philippe A. Halban
Philippe A. Halban University of Geneva
Paolo Meda
Paolo Meda University of Geneva
Leif Groop
Leif Groop Lund University
Werner Schlegel
Werner Schlegel University of Geneva
Erik Renström
Erik Renström Lund University
Hisamitsu Ishihara
Hisamitsu Ishihara Nihon University
Tullio Pozzan
Tullio Pozzan University of Padua
Lena Eliasson
Lena Eliasson Lund University

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