Hisamitsu Ishihara

Overview

Best Publications

• Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.

  H. Ishihara;T. Asano;K. Tsukuda;H. Katagiri

  583
  Citations

• Islet |[beta]|-cell secretion determines glucagon release from neighbouring |[alpha]|-cells

  Hisamitsu Ishihara;Pierre Maechler;Asllan Gjinovci;Pedro-Luis Herrera

  536
  Citations

• Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

  Sonya G. Fonseca;Shinsuke Ishigaki;Christine M. Oslowski;Simin Lu

  432
  Citations

• Type I Phosphatidylinositol-4-phosphate 5-Kinases CLONING OF THE THIRD ISOFORM AND DELETION/SUBSTITUTION ANALYSIS OF MEMBERS OF THIS NOVEL LIPID KINASE FAMILY

  Hisamitsu Ishihara;Yoshikazu Shibasaki;Nobuaki Kizuki;Takako Wada

  407
  Citations

• A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons

  Haruhiko Bito;Tomoyuki Furuyashiki;Hisamitsu Ishihara;Yoshikazu Shibasaki

  391
  Citations

• Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

  Kimberley F. Tolias;John H. Hartwig;John H. Hartwig;Hisamitsu Ishihara;Yoshikazu Shibasaki

  330
  Citations

• WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells

  Takahiro Yamada;Hisamitsu Ishihara;Akira Tamura;Rui Takahashi

  324
  Citations

• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.

  Kenji Uno;Hideki Katagiri;Tetsuya Yamada;Yasushi Ishigaki

  323
  Citations

• Disruption of the WFS1 gene in mice causes progressive β-cell loss and impaired stimulus–secretion coupling in insulin secretion

  Hisamitsu Ishihara;Satoshi Takeda;Akira Tamura;Rui Takahashi

  308
  Citations

• Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes

  Hideki Katagiri;Tomoichiro Asano;Hisamitsu Ishihara;Kouichi Inukai

  290
  Citations

• Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase.

  Hisamitsu Ishihara;Yoshikazu Shibasaki;Nobuaki Kizuki;Hideki Katagiri

  283
  Citations

• Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

  Kohjiro Ueki;Takayoshi Sasako;Yukiko Okazaki;Masayuki Kato

  280
  Citations

• Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver

  Junta Imai;Hideki Katagiri;Tetsuya Yamada;Yasushi Ishigaki

  267
  Citations

• Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells

  Hisamitsu Ishihara;Haiyan Wang;Lester R. Drewes;Claes B. Wollheim

  263
  Citations

• Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.

  Yasushi Ishigaki;Hideki Katagiri;Junhong Gao;Tetsuya Yamada

  262
  Citations

• The role of N-glycosylation of GLUT1 for glucose transport activity.

  T Asano;H Katagiri;K Takata;J L Lin

  244
  Citations

• Massive Actin Polymerization Induced by Phosphatidylinositol-4-phosphate 5-Kinase in Vivo

  Yoshikazu Shibasaki;Hisamitsu Ishihara;Nobuaki Kizuki;Tomoichiro Asano

  244
  Citations

• ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

  Suguru Yamaguchi;Hisamitsu Ishihara;Takahiro Yamada;Akira Tamura

  240
  Citations

• Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.

  Haiyan Wang;Pierre Maechler;Beate Ritz-Laser;Kerstin A. Hagenfeldt

  238
  Citations

• Activation of Type I Phosphatidylinositol 4-Phosphate 5-Kinase Isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42 *

  Paschal A. Oude Weernink;Konstantinos Meletiadis;Silvia Hommeltenberg;Matthias Hinz

  237
  Citations