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Motonobu Anai

Motonobu Anai

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
8505
World Ranking
16324
National Ranking
1170

Overview

Motonobu Anai is affiliated with the University of Tokyo in Japan and has contributed to research primarily within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans significant subfields including Molecular Biology, Epidemiology, Endocrinology, Diabetes and Metabolism, Biomedical Engineering, and Nutrition and Dietetics.

The scientist's research interests are reflected in topics such as Liver Disease Diagnosis and Treatment, Peroxisome Proliferator-Activated Receptors, Diet, Metabolism, and Disease, Trace Elements in Health, Heavy Metal Exposure and Toxicity, Iron Metabolism and Disorders, and Endoplasmic Reticulum Stress and Disease.

Frequent co-authors in their research collaborations include:

  • Tatsuhiko Kodama
  • Yusuke Sasaki
  • Masato Asahiyama
  • Toshiya Tanaka
  • Kentaro Murakami

Several publication venues are notable for hosting their work with recurring contributions, including:

  • European Heart Journal
  • Scientific Reports
  • Journal of Diabetes Investigation
  • Cells
  • Diabetes Obesity and Metabolism

Recent papers authored or co-authored by Motonobu Anai include:

  • "Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content," 2020, Scientific Reports
  • "Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study," 2021, Journal of Diabetes Investigation
  • "Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis," 2022, Cells
  • "Comparison of tofogliflozin versus glimepiride as the third oral agent added to metformin plus a dipeptidyl peptidase-4 inhibitor in Japanese patients with type 2 diabetes: A randomized, 24-week, open-label, controlled trial (STOP-OB)," 2020, Diabetes Obesity and Metabolism
  • "Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area," 2022, Molecular Psychiatry

Best Publications

  • Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.

    H. Ishihara;T. Asano;K. Tsukuda;H. Katagiri

  • T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

    A Oku;K Ueta;K Arakawa;T Ishihara

  • Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling

    Takehide Ogihara;Tomoichiro Asano;Katsuyuki Ando;Yuko Chiba

  • Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells

    Nobuhiro Shojima;Hideyuki Sakoda;Takehide Ogihara;Takehide Ogihara;Midori Fujishiro;Midori Fujishiro

  • Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

    Motonobu Anai;Makoto Funaki;Takehide Ogihara;Jungo Terasaki

  • Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.

    Midori Fujishiro;Yukiko Gotoh;Hideki Katagiri;Hideyuki Sakoda

  • p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin

    Kouichi Inukai;Makoto Funaki;Takehide Ogihara;Hideki Katagiri

  • 14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain

    Takehide Ogihara;Toshiaki Isobe;Tohru Ichimura;Masato Taoka

  • High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.

    Takehide Ogihara;Tomoichiro Asano;Katsuyuki Ando;Hideyuki Sakoda

  • Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

    Hiraku Ono;Hitoshi Shimano;Hideki Katagiri;Naoya Yahagi

  • Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

    T. Ogihara;T. Ogihara;T. Asano;H. Katagiri;H. Sakoda

  • A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene.

    Kouichi Inukai;Motonobu Anai;Eric Van Breda;Toshio Hosaka

  • MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.

    Midori Fujishiro;Yukiko Gotoh;Hideki Katagiri;Hideyuki Sakoda

  • Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity

    Hideyuki Sakoda;Yukiko Gotoh;Hideki Katagiri;Mineo Kurokawa

  • A Novel Protein Kinase B (PKB)/AKT-binding Protein Enhances PKB Kinase Activity and Regulates DNA Synthesis

    Motonobu Anai;Nobuhiro Shojima;Hideki Katagiri;Takehide Ogihara

  • Mitochondrial diabetes mellitus: Prevalence and clinical characterization of diabetes due to mitochondrial tRNALeU(UUR) gene mutation in Japanese patients

    H. Katagiri;I. Asano;H. Ishihara;K. Inukai

  • Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats

    Takehide Ogihara;Tomoichiro Asano;Katsuyuki Ando;Yuko Chiba

  • Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

    Motonobu Anai;Makoto Funaki;Takehide Ogihara;Akira Kanda

  • Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation

    Yukiko Onishi;Miho Honda;Takehide Ogihara;Hideyuki Sakoda

  • Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.

    Hideyuki Sakoda;Takehide Ogihara;Motonobu Anai;Midori Fujishiro

Frequent Co-Authors

Tomoichiro Asano
Tomoichiro Asano Hiroshima University
Yoshitomo Oka
Yoshitomo Oka Tohoku University
Yoshio Yazaki
Yoshio Yazaki University of Tokyo
Hisamitsu Ishihara
Hisamitsu Ishihara Nihon University
Hiroki Kurihara
Hiroki Kurihara University of Tokyo
Juro Sakai
Juro Sakai University of Tokyo
Kuniaki Takata
Kuniaki Takata Gunma University
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Tomoichiro Asano
Tomoichiro Asano Hiroshima University
Tatsuhiko Kodama
Tatsuhiko Kodama University of Tokyo

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