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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
14442
World Ranking
8728
National Ranking
156

Overview

Pierre Maechler is affiliated with the University of Geneva in Switzerland. Their research spans multiple areas primarily within biochemistry, genetics, molecular biology, and medicine, with specific focus on subfields including molecular biology, surgery, endocrinology, diabetes and metabolism, physiology, and biochemistry.

The scientist's main topics of work cover several aspects of pancreatic function and diabetes, metabolism related to diabetes and cancer, mitochondrial function and pathology, diet and metabolism studies, muscle physiology and disorders, as well as diabetes and associated disorders.

Frequent publication venues include International Journal of Molecular Sciences, Human Genomics, IBRO Neuroscience Reports, Nature, and Nature Communications.

Recent notable papers include:

  • Macrophage-derived glutamine boosts satellite cells and muscle regeneration, 2020, Nature
  • Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα, 2021, Nature Communications
  • Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation, 2021, Nature Metabolism
  • AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics, 2020, Glia
  • Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia, 2021, Frontiers in Neuroscience

They have collaborated frequently with:

  • Cecilia Jiménez-Sánchez
  • Lucie Oberhauser
  • Thierry Brun
  • Katrien De Bock
  • Nicola Zamboni

Best Publications

  • Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells

    Arnaud Merglen;Sten Theander;Blanca Rubi;Gaelle Chaffard

  • Mitochondrial function in normal and diabetic beta-cells.

    Pierre Maechler;Claes B. Wollheim

  • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

    Pierre Maechler;Claes B. Wollheim

  • Islet |[beta]|-cell secretion determines glucagon release from neighbouring |[alpha]|-cells

    Hisamitsu Ishihara;Pierre Maechler;Asllan Gjinovci;Pedro-Luis Herrera

  • Regulation of insulin secretion by SIRT4, a mitochondrial ADP -ribosyltransferase

    Nidhi Ahuja;Bjoern Schwer;Stefania Carobbio;David Waltregny

  • Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA.

    Philippe Parone;Sandrine Da Cruz;Daniel Tondera;Yves Benoît Mattenberger

  • Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

    Pierre Maechler;Lan Jornot;Claes B. Wollheim

  • New insights into amino acid metabolism, β-cell function and diabetes

    Philip Newsholme;Lorraine Brennan;Blanca Rubi;Pierre Maechler

  • Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion

    Blanca Rubí;Sanda Ljubicic;Shirin Pournourmohammadi;Stefania Carobbio

  • Mitochondrial dysfunction in pancreatic β cells

    Sachin Supale;Ning Li;Thierry Brun;Pierre Maechler

  • Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion

    Haiyan Wang;Pierre Maechler;Peter A. Antinozzi;Kerstin A. Hagenfeldt

  • Saturated fatty acid‐induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

    Sandro M. Hirabara;Rui Curi;Pierre Maechler

  • Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.

    Haiyan Wang;Pierre Maechler;Beate Ritz-Laser;Kerstin A. Hagenfeldt

  • Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

    Pierre Maechler;Eleanor D. Kennedy;Tullio Pozzan;Claes B. Wollheim

  • Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance

    Blanca Rubí;Pierre Maechler

  • Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

    Laurene Marine Vetterli;Thierry Brun;Laurianne Giovannoni;Domenico Bosco

  • Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

    Haiyan Wang;Pierre Maechler;Kerstin A. Hagenfeldt;Claes B. Wollheim

  • Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

    E D Kennedy;P Maechler;C B Wollheim

  • Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell.

    Pierre Maechler;Claes B. Wollheim

  • In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.

    Pierre Maechler;Stefania Carobbio;Blanca Rubi

Frequent Co-Authors

Claes B. Wollheim
Claes B. Wollheim University of Geneva
Susanne Mandrup
Susanne Mandrup University of Southern Denmark
Helle S. Waagepetersen
Helle S. Waagepetersen University of Copenhagen
Hisamitsu Ishihara
Hisamitsu Ishihara Nihon University
Rolf Gruetter
Rolf Gruetter École Polytechnique Fédérale de Lausanne
Philip Newsholme
Philip Newsholme Curtin University
Paolo Meda
Paolo Meda University of Geneva
Pascale Gaudet
Pascale Gaudet Swiss Institute of Bioinformatics
Emmanouil T. Dermitzakis
Emmanouil T. Dermitzakis University of Geneva

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