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Medicine

D-Index
116
Citations
45012
World Ranking
4390
National Ranking
44

Overview

Decio L. Eizirik is affiliated with the Université Libre de Bruxelles in Belgium and specializes in research areas spanning biochemistry, genetics, molecular biology, and medicine. The scientist's work is prominently situated within the subfields of surgery, genetics, molecular biology, endocrinology, diabetes and metabolism, and immunology.

The research topics covered by Decio L. Eizirik largely focus on pancreatic function and diabetes, diabetes and associated disorders, diabetes management and research, immune cell function and interaction, endoplasmic reticulum stress and disease, RNA modifications and cancer, and diet, metabolism, and disease.

Eizirik has contributed extensively to scholarly articles published in various scientific journals. Frequently appearing publication venues include bioRxiv (Cold Spring Harbor Laboratory), Diabetologia, Diabetes, Nature Communications, and iScience.

Among recent papers authored or co-authored by Decio L. Eizirik are:

  • Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure, 2020, Nature Reviews Endocrinology
  • SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature, 2020, Frontiers in Endocrinology
  • An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells, 2020, Nature Communications
  • Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention, 2020, Cell Metabolism
  • Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes, 2020, Cell Reports

The scientist has collaborated regularly with several researchers in the field, including co-authors such as Piero Marchetti, Miriam Cnop, Lorella Marselli, Xiaoyan Yi, and Máikel L. Colli.

Best Publications

  • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

    Miriam Cnop;Nils Welsh;Jean-Christophe Jonas;Anne Jörns

  • The role for endoplasmic reticulum stress in diabetes mellitus.

    Décio L. Eizirik;Alessandra K. Cardozo;Miriam Cnop;Miriam Cnop

  • A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis

    Decio L. Eizirik;T. Mandrup-Poulsen

  • The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.

    Decio L. Eizirik;Maikel Luis Colli;Fernanda Ortis

  • Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

    Ilham Kharroubi;Laurence Ladrière;Alessandra K Cardozo;Zeynep Dogusan

  • Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

    Miriam Cnop;Jean Claude Hannaert;Anne Hoorens;Décio L. Eizirik

  • Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

    Alessandra K. Cardozo;Fernanda Ortis;Joachim Storling;Ying-Mei Feng

  • Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

    Daniel A. Cunha;Paul Hekerman;Laurence Ladrière;Angie Bazarra-Castro

  • Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.

    Décio L Eizirik;Décio L Eizirik;Lorenzo Pasquali;Lorenzo Pasquali;Miriam Cnop

  • The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

    Décio L. Eizirik;Michael Sammeth;Thomas Bouckenooghe;Guy Bottu

  • Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase

    Nils Welsh;Decio L. Eizirik;Klaus Bendtzen;Stellan Sandler

  • DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.

    Michael Volkmar;Sarah Dedeurwaerder;Daniel A Cunha;Matladi N Ndlovu

  • Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells

    Carol A. Delaney;Dejan Pavlovic;Anne Hoorens;Daniel G. Pipeleers

  • The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

    Decio L. Eizirik;M Flodström;A E Karlsen;N Welsh

  • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.

    Decio L. Eizirik;Gregory S. Korbutt;Claes Hellerstrom

  • Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis

    Miriam Cnop;Miriam Cnop;Laurence Ladriere;Paul Hekerman;Fernanda Ortis

  • A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

    Alessandra K. Cardozo;Harry Heimberg;Yves Heremans;Ruth Leeman

  • Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

    Décio L. Eizirik;Stellan Sandler;Nils Welsh;Marina Cetkovic-Cvrlje

  • Expression of adiponectin receptors in pancreatic beta cells.

    Ilham Kharroubi;Joanne Rasschaert;Décio L Eizirik;Miriam Cnop

  • Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.

    Harry Heimberg;Yves Heremans;Christian Jobin;Ruth Leemans

Frequent Co-Authors

Piero Marchetti
Piero Marchetti University of Pisa
Miriam Cnop
Miriam Cnop Université Libre de Bruxelles
Claes Hellerström
Claes Hellerström Uppsala University
Stellan Sandler
Stellan Sandler Uppsala University
Daniel Pipeleers
Daniel Pipeleers Vrije Universiteit Brussel
Steven J. Sandler
Steven J. Sandler University of Massachusetts Amherst
Thomas Mandrup-Poulsen
Thomas Mandrup-Poulsen University of Copenhagen
Torben F. Ørntoft
Torben F. Ørntoft Aarhus University

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