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D-Index & Metrics

Chemistry

D-Index
50
Citations
13844
World Ranking
14230
National Ranking
3674

Overview

Giuseppe L. Squadrito is affiliated with the University of Alabama at Birmingham in the United States. Their research work primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a total of seven publications in this area.

The scientist's work includes several focused subfields such as Cancer Research, Molecular Biology, Spectroscopy, and Radiology, Nuclear Medicine and Imaging. The main topics covered in their research encompass Cancer, Hypoxia, and Metabolism, Advanced NMR Techniques and Applications, Advanced MRI Techniques and Applications, ATP Synthase and ATPases Research, Mitochondrial Function and Pathology, RNA modifications and cancer, and Cancer Genomics and Diagnostics.

Frequent co-authors associated with Giuseppe L. Squadrito include:

  • Nobu Oshima
  • Daniel J. Urban
  • Ganesha Rai
  • Michelle S. Johnson
  • Matthew D. Hall

Scientific output has been published in various venues, including:

  • Cell Reports
  • Journal of Medicinal Chemistry
  • Cancer Research

Notable recent publications feature:

  • Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy, 2020, Cell Reports
  • Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties, 2020, Journal of Medicinal Chemistry
  • Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma, 2020, Cancer Research

Best Publications

  • The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

    W. A. Pryor;G. L. Squadrito

  • Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

    Giuseppe L. Squadrito;William A. Pryor

  • Hydrogen sulfide mediates the vasoactivity of garlic

    Gloria A. Benavides;Giuseppe L. Squadrito;Robert W. Mills;Hetal D. Patel

  • Role of free radicals in the toxicity of airborne fine particulate matter.

    Barry Dellinger;William A. Pryor;Rafael Cueto;Giuseppe L. Squadrito

  • Free radical biology and medicine: it's a gas, man!

    William A. Pryor;Kendall N. Houk;Christopher S. Foote;Jon M. Fukuto

  • Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter

    Giuseppe L. Squadrito;Rafael Cueto;Barry Dellinger;William A. Pryor

  • Reaction of Uric Acid with Peroxynitrite and Implications for the Mechanism of Neuroprotection by Uric Acid

    Giuseppe L. Squadrito;Rafael Cueto;Andres E. Splenser;Andres E. Splenser;Athanasios Valavanidis

  • One- and two-electron oxidations of methionine by peroxynitrite.

    William A. Pryor;Xia Jin;Giuseppe L. Squadrito

  • The cascade mechanism to explain ozone toxicity: The role of lipid ozonation products

    William A. Pryor;Giuseppe L. Squadrito;Mitchell Friedman

  • DNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes

    M.G. Salgo;E. Bermudez;G.L. Squadrito;W.A. Pryor

  • Acceleration of peroxynitrite oxidations by carbon dioxide.

    Rao M. Uppu;Giuseppe L. Squadrito;William A. Pryor

  • A practical method for preparing peroxynitrite solutions of low ionic strength and free of hydrogen peroxide

    William A. Pryor;Rafael Cueto;Xia Jin;Willem H. Koppenol

  • Peroxynitrite causes DNA nicks in plasmid pBR322.

    M.G. Salgo;K. Stone;G.L. Squadrito;J.R. Battista

  • The formation of peroxynitrite in vivo from nitric oxide and superoxide

    Giuseppe L. Squadrito;William A. Pryor

  • Peroxynitrite Causes Apoptosis in Rat Thymocytes

    M.G. Salgo;G.L. Squadrito;W.A. Pryor

  • DIRECT AND INDIRECT OXIDATIONS BY PEROXYNITRITE, NEITHER INVOLVING THE HYDROXYL RADICAL

    Sara Goldstein;Giuseppe L. Squadrito;William A. Pryor;Gidon Czapski

  • Inactivation of glutathione peroxidase by peroxynitrite.

    Sarojini Padmaja;Giuseppe L. Squadrito;William A. Pryor

  • Reaction of Peroxynitrite with Melatonin: A Mechanistic Study

    Houwen Zhang;Giuseppe L. Squadrito;Rao Uppu;William A. Pryor

  • Stopped-Flow Kinetic Study of the Reaction of Ascorbic Acid with Peroxynitrite

    G. L. Squadrito;Xia Jin;W. A. Pryor

  • A new mechanism for the toxicity of ozone

    William A. Pryor;Giuseppe L. Squadrito;Mitchell Friedman

  • The reaction of melatonin with peroxynitrite: formation of melatonin radical cation and absence of stable nitrated products.

    Houwen Zhang;Giuseppe L. Squadrito;William A. Pryor

Frequent Co-Authors

William A. Pryor
William A. Pryor Louisiana State University
Sadis Matalon
Sadis Matalon University of Alabama at Birmingham
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Frank R. Fronczek
Frank R. Fronczek Louisiana State University
Matthew D. Hall
Matthew D. Hall National Institutes of Health
Barry Dellinger
Barry Dellinger Louisiana State University
Ajit Jadhav
Ajit Jadhav Pfizer (Germany)
Larry A. Sklar
Larry A. Sklar University of New Mexico
Anton Simeonov
Anton Simeonov National Institutes of Health
Didier Picard
Didier Picard University of Geneva

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