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Biology and Biochemistry

D-Index
93
Citations
31576
World Ranking
2105
National Ranking
1144

Overview

Larry A. Sklar is affiliated with the University of New Mexico in the United States. Their research activity focuses primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these wider fields, their work concentrates on subfields including Molecular Biology, Immunology, Cancer Research, Computational Theory and Mathematics, and Hematology.

The scientist's research topics encompass a range of areas, notably:

  • Cancer, Hypoxia, and Metabolism
  • Computational Drug Discovery Methods
  • Cell death mechanisms and regulation
  • Advanced NMR Techniques and Applications
  • Advanced MRI Techniques and Applications
  • COVID-19 Clinical Research Studies
  • Pharmacological Receptor Mechanisms and Effects

Recent peer-reviewed publications by Larry A. Sklar include:

  • Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy, 2020, Cell Reports
  • Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, 2020, ACS Pharmacology & Translational Science
  • Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties, 2020, Journal of Medicinal Chemistry
  • RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia, 2021, Journal of Clinical Investigation
  • Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells, 2021, FASEB BioAdvances

Frequent co-authors with whom they have collaborated multiple times include:

  • Mark K. Haynes
  • Chien-An Andy Hu
  • Nobu Oshima
  • Daniel J. Urban
  • Ganesha Rai

They have published multiple articles in venues such as:

  • SLAS DISCOVERY
  • Clinical Oncology and Research
  • Cell Reports
  • ACS Pharmacology & Translational Science
  • Journal of Medicinal Chemistry

Best Publications

  • A transmembrane intracellular estrogen receptor mediates rapid cell signaling.

    Chetana M. Revankar;Daniel F. Cimino;Larry A. Sklar;Jeffrey B. Arterburn

  • Virtual and biomolecular screening converge on a selective agonist for GPR30

    Cristian G Bologa;Chetana M Revankar;Susan M Young;Bruce S Edwards

  • Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30

    Eric R. Prossnitz;Jeffrey B. Arterburn;Jeffrey B. Arterburn;Harriet O. Smith;Tudor I. Oprea

  • Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase

    Ingrid U. Schraufstatter;Paul A. Hyslop;Daniel B. Hinshaw;Roger G. Spragg

  • In vivo effects of a GPR30 antagonist

    Megan K Dennis;Ritwik Burai;Chinnasamy Ramesh;Whitney K Petrie

  • Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system

    Eugen Brailoiu;Siok L Dun;G Cristina Brailoiu;Keisuke Mizuo

  • Suspension array technology: evolution of the flat-array paradigm.

    John P. Nolan;Larry A. Sklar

  • A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: Its use in the simultaneous fluorimetric assay of cellular activation processes

    Paul A. Hyslop;Larry A. Sklar

  • Conjugated Polyene Fatty Acids as Fluorescent Probes: Synthetic Phospholipid Membrane Studies

    Larry A. Sklar;Bruce S. Hudson;Robert D. Simoni

  • Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

    David B. Sykes;Youmna S. Kfoury;François E. Mercier;Mathias J. Wawer

  • Drug Repurposing from an Academic Perspective.

    Tudor I. Oprea;Julie E. Bauman;Cristian G. Bologa;Tione Buranda

  • Unexplored therapeutic opportunities in the human genome.

    Tudor I. Oprea;Cristian G. Bologa;Søren Brunak;Allen Campbell

  • GPR30: a G protein-coupled receptor for estrogen

    Eric R. Prossnitz;Jeffrey B. Arterburn;Larry A. Sklar

  • Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.

    Megan K. Dennis;Angela S. Field;Ritwik Burai;Chinnasamy Ramesh

  • Control of Molecular Transport Through Stimuli‐Responsive Ordered Mesoporous Materials

    Q. Fu;G.V.R. Rao;L.K. Ista;Y. Wu

  • Human serum albumin. Spectroscopic studies of binding and proximity relationships for fatty acids and bilirubin.

    C B Berde;B S Hudson;R D Simoni;L A Sklar

  • Pharos: Collating protein information to shed light on the druggable genome

    Dac-Trung Nguyen;Stephen L. Mathias;Cristian Bologa;Søren Brunak

  • An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

    Alexis E. Traynor-Kaplan;Anna L. Harris;Barbara L. Thompson;Palmer Taylor

  • Phospholipid lateral phase separation and the partition of cis-parinaric acid and trans-parinaric acid among aqueous, solid lipid, and fluid lipid phases

    Larry A. Sklar;George P. Miljanich;Edward A. Dratz

  • Cytoskeletal and morphologic impact of cellular oxidant injury.

    D. B. Hinshaw;L. A. Sklar;B. Bohl;I. U. Schraufstatter

Frequent Co-Authors

Eric R. Prossnitz
Eric R. Prossnitz University of New Mexico
George P. Tegos
George P. Tegos University of New Mexico
Angela Wandinger-Ness
Angela Wandinger-Ness University of New Mexico
Claudio De Virgilio
Claudio De Virgilio University of Fribourg
Robbie Loewith
Robbie Loewith University of Geneva
Jeffrey Aubé
Jeffrey Aubé University of North Carolina at Chapel Hill
Charles G. Cochrane
Charles G. Cochrane Scripps Research Institute
Algirdas J. Jesaitis
Algirdas J. Jesaitis Montana State University
Gabriel P. Lopez
Gabriel P. Lopez University of New Mexico
Laurie G. Hudson
Laurie G. Hudson University of New Mexico

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