World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
60
Citations
11482
World Ranking
1978
National Ranking
983

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Binghui Shen is affiliated with the City Of Hope National Medical Center in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology with notable contributions to medicine. The main areas of study include molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and immunology.

The scientist's work encompasses several key topics such as DNA repair mechanisms, CRISPR and genetic engineering, cancer-related gene regulation, epigenetics and DNA methylation, RNA modifications and cancer, cancer genomics and diagnostics, and advanced biosensing and bioanalysis techniques.

Frequent publication venues for Shen include bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Nucleic Acids Research, Nature Communications, and Theranostics. Their works appear in these venues repeatedly, indicating sustained contributions to these journals and platforms.

Shen has collaborated frequently with several co-authors including Li Zheng (19 collaborations), Mian Zhou (9), Jessica D. Hess (6), Rui Su (5), and Haitao Sun (5).

Selected recent papers include:

  • Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly, 2020, Nature Communications
  • RNA N6-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer, 2022, Theranostics
  • Role of 53BP1 in end protection and DNA synthesis at DNA breaks, 2021, Genes & Development
  • Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival, 2022, Trends in Cell Biology
  • Arginine methylation of APE1 promotes its mitochondrial translocation to protect cells from oxidative damage, 2020, Free Radical Biology and Medicine

In recognition of their scientific contributions, Binghui Shen was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    Arnab Ray Chaudhuri;Elsa Callen;Xia Ding;Ewa Gogola

  • Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair

    Brian R Chapados;David J Hosfield;Seungil Han;Junzhuan Qiu

  • Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

    Susan E. Tsutakawa;Scott Classen;Brian R. Chapados;Andrew S. Arvai

  • Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1: Coupling DNA and PCNA Binding to FEN-1 Activity

    David J Hosfield;Clifford D Mol;Binghui Shen;John A Tainer

  • Fen1 mutations result in autoimmunity, chronic inflammation and cancers

    Li Zheng;Huifang Dai;Mian Zhou;Mei Li

  • Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

    Li Zheng;Mian Zhou;Zhigang Guo;Huiming Lu

  • O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth.

    Xiongjian Rao;Xiaotao Duan;Weimin Mao;Xuexia Li

  • PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans

    Yuejin Hua;Issay Narumi;Guanjun Gao;Bing Tian

  • Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

    Pingfang Liu;Limin Qian;Jung-Suk Sung;Nadja C. de Souza-Pinto

  • Functional regulation of FEN1 nuclease and its link to cancer

    Li Zheng;Jia Jia;L. David Finger;Zhigang Guo

  • Okazaki fragment maturation: nucleases take centre stage

    Li Zheng;Binghui Shen

  • Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases

    Binghui Shen;Purnima Singh;Ren Liu;Junzhuan Qiu

  • Reciprocal Regulation of Akt and Oct4 Promotes the Self-Renewal and Survival of Embryonal Carcinoma Cells

    Yuanji Lin;Ying Yang;Weihua Li;Qi Chen

  • Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease.

    Junzhuan Qiu;Ying Qian;Peter Frank;Ulrike Wintersberger

  • Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

    Li Zheng;Mian Zhou;Qing Chai;Jay Parrish

  • Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

    Weiqiang Lin;Shilpa Sampathi;Huifang Dai;Changwei Liu;Changwei Liu

  • Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

    Zhigang Guo;Li Zheng;Hong Xu;Huifang Dai

  • Overexpression and Hypomethylation of Flap Endonuclease 1 Gene in Breast and Other Cancers

    Purnima Singh;Ming Yang;Huifang Dai;Dianke Yu

  • CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity

    Hailong Wang;Yongjiang Li;Lan N. Truong;Linda Z. Shi

  • CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation

    Jay Z. Parrish;Chonglin Yang;Binghui Shen;Ding Xue

Frequent Co-Authors

John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Larry A. Sklar
Larry A. Sklar University of New Mexico
Xiwei Wu
Xiwei Wu City Of Hope National Medical Center
Gerd P. Pfeifer
Gerd P. Pfeifer Van Andel Institute
James H. Doroshow
James H. Doroshow National Institutes of Health
Judith L. Campbell
Judith L. Campbell California Institute of Technology
Yuan Chen
Yuan Chen University of Sydney
Sven Rottenberg
Sven Rottenberg University of Bern
Dongxin Lin
Dongxin Lin Chinese Academy of Sciences
Giacomo P. Comi
Giacomo P. Comi University of Milan

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