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Overview

Tapas K. Hazra is affiliated with The University of Texas Medical Branch at Galveston in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine as well. The scientist's work spans multiple subfields including molecular biology, immunology, cellular and molecular neuroscience, epidemiology, and oncology.

The main topics Hazra addresses in their research include:

  • DNA Repair Mechanisms
  • Mitochondrial Function and Pathology
  • Genetic Neurodegenerative Diseases
  • Respiratory viral infections research
  • Genetic factors in colorectal cancer
  • DNA and Nucleic Acid Chemistry
  • RNA modifications and cancer

Recent publications illustrate the scope of Hazra's research interests and their contributions to understanding DNA repair and disease mechanisms. Selected recent papers are:

  • "Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells" (2020) published in Journal of Biological Chemistry
  • "The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells" (2020) published in Cells
  • "PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease" (2021) published in Proceedings of the National Academy of Sciences
  • "Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis" (2020) published in Proceedings of the National Academy of Sciences
  • "Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover" (2021) published in DNA repair

Hazra's frequent collaborators include:

  • Anirban Chakraborty
  • István Boldogh
  • Soumita Das
  • Nisha Tapryal
  • Azharul Islam

The scientist often publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences
  • Methods in Molecular Biology
  • Indian Journal of Animal Health

Best Publications

  • Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.

    Muralidhar L Hegde;Tapas K Hazra;Sankar Mitra

  • Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.

    Tapas K. Hazra;Tadahide Izumi;Istvan Boldogh;Barry Imhoff

  • AP endonuclease-independent DNA base excision repair in human cells

    Lee R Wiederhold;John B. Leppard;Padmini Kedar;Feridoun Karimi-Busheri

  • Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

    Jeff W. Hill;Tapas K. Hazra;Tadahide Izumi;Sankar Mitra

  • ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

    Istvan Boldogh;Attila Bacsi;Barun K. Choudhury;Nilesh Dharajiya

  • Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.

    Hong Dou;Sankar Mitra;Tapas K. Hazra

  • Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.

    Tapas K. Hazra;Yoke W. Kow;Zafar Hatahet;Barry Imhoff

  • Oxidative DNA damage repair in mammalian cells: a new perspective.

    Tapas K. Hazra;Aditi Das;Soumita Das;Sujata Choudhury

  • Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

    Tadahide Izumi;Lee R. Wiederhold;Gargi Roy;Rabindra Roy

  • Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species

    Tadahide Izumi;Tapas K. Hazra;Istvan Boldogh;Alan E. Tomkinson

  • Thirdhand smoke causes DNA damage in human cells

    Bo Hang;Altaf H. Sarker;Christopher Havel;Saikat Saha

  • The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation

    Tapas K. Hazra;Tadahide Izumi;Lindsay Maidt;Robert A. Floyd

  • Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells

    Guichun Wang;Tapas K. Hazra;Sankar Mitra;Heung Man Lee

  • Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.

    Kishor K. Bhakat;Sanath K. Mokkapati;Istvan Boldogh;Tapas K. Hazra

  • Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

    Kishor K. Bhakat;Tadahide Izumi;Suk Hoon Yang;Tapas K. Hazra

  • Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

    Lang Pan;Lang Pan;Bing Zhu;Wenjing Hao;Xianlu Zeng

  • Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

    Sankar Mitra;Istvan Boldogh;Tadahide Izumi;Tapas K. Hazra

  • Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

    Ranajoy Chattopadhyay;Lee R Wiederhold;Bartosz Szczesny;Istvan Boldogh

  • Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

    Anirban Chakraborty;Nisha Tapryal;Tatiana Venkova;Nobuo Horikoshi

  • Choreography of oxidative damage repair in mammalian genomes.

    Sankar Mitra;Tadahide Izumi;Istvan Boldogh;Kishor K Bhakat

Frequent Co-Authors

Sankar Mitra
Sankar Mitra Houston Methodist
Istvan Boldogh
Istvan Boldogh The University of Texas Medical Branch at Galveston
Sanjiv Sur
Sanjiv Sur The University of Texas Medical Branch at Galveston
Zsolt Radak
Zsolt Radak Waseda University
Santi M. Mandal
Santi M. Mandal University of California, San Diego
Alan E. Tomkinson
Alan E. Tomkinson University of New Mexico
Tej K. Pandita
Tej K. Pandita Houston Methodist
Allan R. Brasier
Allan R. Brasier University of Wisconsin–Madison
Tetsuo Ashizawa
Tetsuo Ashizawa Houston Methodist
Octavio L. Franco
Octavio L. Franco Universidade Católica de Brasília

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