Mark R. Kelley mainly focuses on DNA repair, DNA- lyase, Molecular biology, AP site and Base excision repair. The study incorporates disciplines such as DNA damage and Phosphorylation, Cell biology in addition to DNA repair. Mark R. Kelley has researched DNA- lyase in several fields, including AP endonuclease, Cancer research, Transcription factor and Sarcoma.
His work deals with themes such as Cancer and Pathology, which intersect with Cancer research. The Transcription factor study combines topics in areas such as DNA and Transfection. The various areas that Mark R. Kelley examines in his Base excision repair study include Nuclear DNA, Mitochondrial DNA and DNA mismatch repair.
His primary areas of study are DNA repair, Cancer research, Molecular biology, AP site and Base excision repair. His biological study spans a wide range of topics, including Oxidative stress, DNA damage and Cell biology. His Cancer research study combines topics from a wide range of disciplines, such as Cancer, Metastasis, Pancreatic cancer, Transcription factor and STAT3.
His Molecular biology research includes elements of 8-Oxoguanine, DNA glycosylase, Apoptosis and Gene, Transfection. His AP site study focuses mostly on DNA- lyase and AP endonuclease. His Base excision repair study combines topics from a wide range of disciplines, such as Cancer cell and Methyl methanesulfonate.
Mark R. Kelley mostly deals with Cancer research, Endonuclease, Cancer, AP site and Transcription factor. His Endonuclease research is multidisciplinary, relying on both Base excision repair and Retinal. His study looks at the relationship between Base excision repair and topics such as Enzyme, which overlap with DNA repair.
His AP site research is under the purview of DNA damage. His DNA damage study introduces a deeper knowledge of Biochemistry. His biological study spans a wide range of topics, including Cell biology, Regulation of gene expression, Downregulation and upregulation and Stroma.
Mark R. Kelley spends much of his time researching Cancer research, Endonuclease, Cancer, Transcription factor and STAT3. His study in Cancer research is interdisciplinary in nature, drawing from both Bladder cancer, Inflammation, Immunotherapy, Ape1 ref 1 and Effector. His research integrates issues of Base excision repair and Retinal in his study of Endonuclease.
His work carried out in the field of Cancer brings together such families of science as Oncology, MEDLINE, Chemotherapy, Guideline and Chemotherapy-induced peripheral neuropathy. The study incorporates disciplines such as Cell culture, Stroma, Reactive oxygen species, Downregulation and upregulation and Regulation of gene expression in addition to Transcription factor. His research in AP site intersects with topics in Coactivator, Signal transduction, Cell biology and DNA Repair Pathway.
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Going APE over ref-1.
Angela R. Evans;Melissa Limp-Foster;Mark R. Kelley.
Mutation Research-dna Repair (2000)
The many functions of APE1/Ref-1: Not only a DNA repair enzyme
Gianluca Tell;Franco Quadrifoglio;Claudio Tiribelli;Mark R. Kelley.
Antioxidants & Redox Signaling (2009)
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
Gianluca Tell;Giuseppe Damante;David Caldwell;Mark R. Kelley.
Antioxidants & Redox Signaling (2005)
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism.
Young R. Seo;Mark R. Kelley;Martin L. Smith.
Proceedings of the National Academy of Sciences of the United States of America (2002)
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
Melissa L. Fishel;Mark R. Kelley.
Molecular Aspects of Medicine (2007)
DNA repair in neurons: So if they don’t divide what's to repair?
Melissa L. Fishel;Michael R. Vasko;Mark R. Kelley.
Mutation Research (2007)
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
Dong Wang;Meihua Luo;Mark R. Kelley.
Molecular Cancer Therapeutics (2004)
Altered Expression of Ape1/ref-1 in Germ Cell Tumors and Overexpression in NT2 Cells Confers Resistance to Bleomycin and Radiation
Kent A. Robertson;Heather A. Bullock;Yi Xu;Renee Tritt.
Cancer Research (2001)
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
Mark R. Kelley;Liang Cheng;Richard Foster;Renee Tritt.
Clinical Cancer Research (2001)
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process
Carlo Vascotto;Damiano Fantini;Milena Romanello;Laura Cesaratto.
Molecular and Cellular Biology (2009)
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