2026 Mark R. Kelley: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	82	3763	3465	1861	1674	277	19845

Overview

Mark R. Kelley is affiliated with Indiana University in the United States and has a research portfolio spanning biochemistry, genetics, molecular biology, and medicine. Their published work centers on molecular biology, cancer research, neurology, oncology, and physiology, reflecting a multidisciplinary approach to biomedical sciences.

The scientist's main fields of study include:

Biochemistry, Genetics and Molecular Biology
Medicine

Subfields of study represented in their research are:

Molecular Biology
Cancer Research
Neurology
Oncology
Physiology

The primary topics explored by Mark R. Kelley encompass:

Cancer, Hypoxia, and Metabolism
Neurofibromatosis and Schwannoma Cases
Adenosine and Purinergic Signaling
CO2 Sequestration and Geologic Interactions
Cancer Treatment and Pharmacology
Retinal Development and Disorders
Retinal Diseases and Treatments

Their contributions have appeared in several frequent publication venues, including:

OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
Cancer Research
Journal of Cellular Signaling
Gastroenterology
British Journal of Cancer

Some of the notable recent papers by Mark R. Kelley are:

"Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update," 2020, Journal of Clinical Oncology
"Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target," 2021, Journal of Experimental & Clinical Cancer Research
"Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours," 2021, British Journal of Cancer
"APE1/Ref-1 as a Novel Target for Retinal Diseases," 2021, Journal of Cellular Signaling
"Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models," 2020, Journal of Cellular and Molecular Medicine

Frequent collaborators in their research include:

Melissa L. Fishel
Silpa Gampala
Randall Wireman
Olivia Babb
Millie M. Georgiadis

Best Publications

Going APE over ref-1.

Angela R. Evans;Melissa Limp-Foster;Mark R. Kelley

781
Citations
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update

Charles L. Loprinzi;Christina Lacchetti;Jonathan Bleeker;Guido Cavaletti

690
Citations
The many functions of APE1/Ref-1: Not only a DNA repair enzyme

Gianluca Tell;Franco Quadrifoglio;Claudio Tiribelli;Mark R. Kelley

561
Citations
Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy

Daniel Shae;Kyle W. Becker;Plamen Christov;Dong Soo Yun

527
Citations
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

Gianluca Tell;Giuseppe Damante;David Caldwell;Mark R. Kelley

445
Citations
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism.

Young R. Seo;Mark R. Kelley;Martin L. Smith

403
Citations
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

Melissa L. Fishel;Mark R. Kelley

358
Citations
DNA repair in neurons: So if they don’t divide what's to repair?

Melissa L. Fishel;Michael R. Vasko;Mark R. Kelley

322
Citations
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.

Dong Wang;Meihua Luo;Mark R. Kelley

308
Citations
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Zhigang Cai;Jonathan J. Kotzin;Baskar Ramdas;Sisi Chen

300
Citations
Altered Expression of Ape1/ref-1 in Germ Cell Tumors and Overexpression in NT2 Cells Confers Resistance to Bleomycin and Radiation

Kent A. Robertson;Heather A. Bullock;Yi Xu;Renee Tritt

267
Citations
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

Carlo Vascotto;Damiano Fantini;Milena Romanello;Laura Cesaratto

260
Citations
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.

Mark R. Kelley;Liang Cheng;Richard Foster;Renee Tritt

257
Citations
Update on Late Relapse of Germ Cell Tumor: A Clinical and Molecular Analysis

David W. George;Richard S. Foster;Robert A. Hromas;Robert A. Hromas;Kent A. Robertson

225
Citations
The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression

Ying Guo;Robert Costa;Heather Ramsey;Trevor Starnes

217
Citations
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.

Meihua Luo;Sarah Delaplane;Aihua Jiang;April Reed

210
Citations
Enhanced Mitochondrial DNA Repair and Cellular Survival after Oxidative Stress by Targeting the Human 8-Oxoguanine Glycosylase Repair Enzyme to Mitochondria

Allison W. Dobson;Yi Xu;Mark R. Kelley;Susan P. LeDoux

201
Citations
APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.

Mark R. Kelley;Millie M. Georgiadis;Melissa L. Fishel

200
Citations
Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.

Melissa L. Fishel;Ying He;Martin L. Smith;Mark R. Kelley

188
Citations
The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress.

Michael R. Vasko;Chunlu Guo;Mark R. Kelley

179
Citations