D-Index & Metrics Best Publications
Chemistry
Italy
2022
Biology and Biochemistry
Italy
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 137 Citations 83,617 1,645 World Ranking 70 National Ranking 1
Biology and Biochemistry D-index 144 Citations 85,773 1,428 World Ranking 98 National Ranking 1

Research.com Recognitions

Awards & Achievements

2022 - Research.com Biology and Biochemistry in Italy Leader Award

2022 - Research.com Chemistry in Italy Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Organic chemistry

Claudiu T. Supuran mainly focuses on Carbonic anhydrase, Enzyme, Biochemistry, Stereochemistry and Isozyme. He interconnects Mechanism of action, Active site, Sulfonamide, Enzyme inhibitor and Acetazolamide in the investigation of issues within Carbonic anhydrase. His research investigates the connection with Enzyme and areas like Chemical synthesis which intersect with concerns in Medicinal chemistry.

His Biochemistry study combines topics from a wide range of disciplines, such as Bicarbonate and Pharmacology. His Stereochemistry study deals with Sulfamide intersecting with Sulfamic acid. The various areas that Claudiu T. Supuran examines in his Isozyme study include Enzyme activator, Phenols and Cytosol.

His most cited work include:

  • Carbonic anhydrases: novel therapeutic applications for inhibitors and activators (2039 citations)
  • Interfering with pH regulation in tumours as a therapeutic strategy (988 citations)
  • Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms? (744 citations)

What are the main themes of his work throughout his whole career to date?

Claudiu T. Supuran spends much of his time researching Carbonic anhydrase, Biochemistry, Enzyme, Stereochemistry and Isozyme. His Carbonic anhydrase research incorporates elements of Active site, Cytosol, Sulfonamide, Enzyme inhibitor and Gene isoform. Claudiu T. Supuran has researched Biochemistry in several fields, including Sulfonamide and Acetazolamide.

His Acetazolamide research includes elements of Methazolamide and Ethoxzolamide. His Enzyme research focuses on subjects like Sulfamide, which are linked to Sulfamic acid. The Stereochemistry study combines topics in areas such as Selectivity, Structure–activity relationship, Carbonic anhydrase II and Carbonic Anhydrase I.

He most often published in these fields:

  • Carbonic anhydrase (75.58%)
  • Biochemistry (48.35%)
  • Enzyme (43.24%)

What were the highlights of his more recent work (between 2018-2021)?

  • Carbonic anhydrase (75.58%)
  • Biochemistry (48.35%)
  • Gene isoform (19.80%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Carbonic anhydrase, Biochemistry, Gene isoform, Stereochemistry and Enzyme. His work focuses on many connections between Carbonic anhydrase and other disciplines, such as Cytosol, that overlap with his field of interest in Transmembrane protein. As a part of the same scientific study, Claudiu T. Supuran usually deals with the Biochemistry, concentrating on Bacteria and frequently concerns with Microbiology.

His research integrates issues of Inhibitory postsynaptic potential, Coumarin, Carbonic Anhydrase IX, Biological evaluation and Isozyme in his study of Gene isoform. The concepts of his Stereochemistry study are interwoven with issues in Aryl and Carbonic anhydrase II. The Enzyme study combines topics in areas such as Bicarbonate and Sulfamide.

Between 2018 and 2021, his most popular works were:

  • Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery. (63 citations)
  • Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes. (58 citations)
  • Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity (53 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Gene

Carbonic anhydrase, Biochemistry, Gene isoform, Stereochemistry and Enzyme are his primary areas of study. His Carbonic anhydrase research incorporates themes from In vitro, Active site, Molecular model, Coumarin and Sulfonamide. His Biochemistry research integrates issues from Cell culture and Inhibitory postsynaptic potential.

His Gene isoform study incorporates themes from Cancer cell, Carbonic anhydrase II, Selectivity, Structure–activity relationship and Acetazolamide. Claudiu T. Supuran has researched Stereochemistry in several fields, including Triazole and Biological activity. His work in Enzyme tackles topics such as Microbiology which are related to areas like Leishmania.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

Claudiu T. Supuran.
Nature Reviews Drug Discovery (2008)

2689 Citations

Interfering with pH regulation in tumours as a therapeutic strategy

Dario Neri;Claudiu T. Supuran.
Nature Reviews Drug Discovery (2011)

1242 Citations

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

Vincenzo Alterio;Anna Di Fiore;Katia D’Ambrosio;Claudiu T. Supuran.
Chemical Reviews (2012)

905 Citations

Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.

Silvia Pastorekova;Seppo Parkkila;Jaromir Pastorek;Claudiu T Supuran.
Journal of Enzyme Inhibition and Medicinal Chemistry (2004)

822 Citations

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

Eliška Švastová;Alžbeta Hulı́ková;Monika Rafajová;Miriam Zat'ovičová.
FEBS Letters (2004)

713 Citations

Anticancer and antiviral sulfonamides.

Andrea Scozzafava;Takashi Owa;Antonio Mastrolorenzo;Claudiu T. Supuran.
Current Medicinal Chemistry (2003)

702 Citations

Carbonic anhydrase inhibitors

Claudiu T. Supuran.
Bioorganic & Medicinal Chemistry Letters (2003)

608 Citations

How many carbonic anhydrase inhibition mechanisms exist

Claudiu T. Supuran.
Journal of Enzyme Inhibition and Medicinal Chemistry (2016)

593 Citations

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Yuanmei Lou;Paul C McDonald;Arusha Oloumi;Stephen K. Chia.
Cancer Research (2011)

591 Citations

Carbonic anhydrases as targets for medicinal chemistry

Claudiu T. Supuran;Andrea Scozzafava.
Bioorganic & Medicinal Chemistry (2007)

579 Citations

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