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Hatem A. Abdel-Aziz

Hatem A. Abdel-Aziz

D-Index & Metrics

Chemistry

D-Index
55
Citations
7689
World Ranking
12423
National Ranking
61

Overview

Hatem A. Abdel-Aziz is affiliated with King Saud University in Saudi Arabia and has a research focus encompassing chemistry, medicine, and biochemistry, genetics, and molecular biology. Their work primarily addresses organic chemistry, molecular biology, pharmacology, pathology and forensic medicine, and oncology.

The scientist's research concentrates on several key topics including synthesis and biological activity, enzyme function and inhibition, synthesis and catalytic reactions, cancer mechanisms and therapy, synthesis and characterization of heterocyclic compounds, cancer therapeutics and mechanisms, and cholinesterase and neurodegenerative diseases.

Among recent publications authored by or involving Hatem A. Abdel-Aziz are:

  • Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations (2021, Bioorganic Chemistry)
  • Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights (2020, Journal of Enzyme Inhibition and Medicinal Chemistry)
  • 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies (2020, European Journal of Medicinal Chemistry)
  • Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors (2020, Molecules)
  • Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer (2020, ACS Medicinal Chemistry Letters)

Frequent collaborators in research include Wagdy M. Eldehna, Mahmoud S. Elkotamy, Tarfah Al-Warhi, Claudiu T. Supuran, and Alessio Nocentini.

Hatem A. Abdel-Aziz's work has been published predominantly in the following venues:

  • Bioorganic Chemistry (20 publications)
  • European Journal of Medicinal Chemistry (14 publications)
  • Journal of Enzyme Inhibition and Medicinal Chemistry (11 publications)
  • Drug Development Research (7 publications)
  • International Journal of Biological Macromolecules (4 publications)

Best Publications

  • Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles.

    Bakr F. Abdel-Wahab;Hatem A. Abdel-Aziz;Essam M. Ahmed

  • Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies

    Wagdy M. Eldehna;Mahmoud F. Abo-Ashour;Alessio Nocentini;Paola Gratteri

  • Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest.

    Mohamed Fares;Sahar Mahmoud Abou-Seri;Hatem A. Abdel-Aziz;Safinaz E.-S. Abbas

  • Nanomolar Detection of Hypochlorite by a Rhodamine-Based Chiral Hydrazide in Absolute Aqueous Media: Application in Tap Water Analysis with Live-Cell Imaging

    Shyamaprosad Goswami;Avijit Kumar Das;Abhishek Manna;Anup Kumar Maity

  • Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents.

    Wagdy M. Eldehna;Ayman Altoukhy;Hoda Mahrous;Hatem A. Abdel-Aziz

  • Design, synthesis and antitubercular activity of certain nicotinic Acid hydrazides.

    Wagdy M Eldehna;Mohamed Fares;Marwa M Abdel-Aziz;Hatem A Abdel-Aziz;Hatem A Abdel-Aziz

  • Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.

    Hany S. Ibrahim;Sahar M. Abou-Seri;Muhammet Tanc;Mahmoud M. Elaasser

  • Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

    Wagdy M. Eldehna;Mahmoud F. Abo-Ashour;Alessio Nocentini;Radwan S. El-Haggar

  • Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds.

    Hany S. Ibrahim;Wagdy M. Eldehna;Hatem A. Abdel-Aziz;Mahmoud M. Elaasser

  • Microwave-assisted synthesis and in-vitro anti-tumor activity of 1,3,4-triaryl-5-N-arylpyrazole-carboxamides

    Hatem A. Abdel-Aziz;Heba S.A. El-Zahabi;Kamal M. Dawood

  • Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

    Wagdy M Eldehna;Hadia Almahli;Ghada H Al-Ansary;Hazem A Ghabbour

  • Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones

    Hatem A. Abdel-Aziz;Amal A.I. Mekawey

  • Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations.

    Wagdy M. Eldehna;Mahmoud A. El Hassab;Mahmoud F. Abo-Ashour;Tarfah Al-Warhi

  • Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives

    Hatem A. Abdel-Aziz;Amal A.I. Mekawey;Kamal M. Dawood

  • Synthesis and antimicrobial evaluation of some 1,3-thiazole, 1,3,4-thiadiazole, 1,2,4-triazole, and 1,2,4-triazolo[3,4-b][1,3,4]-thiadiazine derivatives including a 5-(benzofuran-2-yl)-1-phenylpyrazole moiety

    Bakr F. Abdel-Wahab;Hatem A. Abdel-Aziz;Essam M. Ahmed

  • Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.

    Wagdy M. Eldehna;Mohamed Fares;Mariangela Ceruso;Hazem A. Ghabbour

  • Convenient Synthesis and Antimicrobial Activity of New 3‐Substituted 5‐(Benzofuran‐2‐yl)‐pyrazole Derivatives

    Bakr F. Abdel-Wahab;Hatem A. Abdel-Aziz;Essam M. Ahmed

  • Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.

    Hany S. Ibrahim;Heba Abdelrasheed Allam;Walaa R. Mahmoud;Alessandro Bonardi

  • Facile Synthesis and In‐Vitro Antitumor Activity of Some Pyrazolo[3,4‐b]pyridines and Pyrazolo[1,5‐a]pyrimidines Linked to a Thiazolo[3,2‐a]benzimidazole Moiety

    Hatem A. Abdel-Aziz;Tamer S. Saleh;Heba S. A. El-Zahabi

  • Synthesis of New Heterocycles Derived from 3-(3-Methyl-1H-indol-2-yl)-3-oxopropanenitrile as Potent Antifungal Agents

    Sobhi M. Gomha;Hatem A. Abdel-Aziz

  • Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

    Wagdy M. Eldehna;Ghada S. Hassan;Sara T. Al-Rashood;Tarfah Al-Warhi

  • Synthesis and antimicrobial evaluation of some 1,2,4-triazole, 1,3,4-oxa(thia)diazole, and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives

    Kamal M. Dawood;Ahmad M. Farag;Hatem A. Abdel-Aziz

Frequent Co-Authors

Wagdy M. Eldehna
Wagdy M. Eldehna Kafrelsheikh University
Hoong-Kun Fun
Hoong-Kun Fun Universiti Sains Malaysia
Claudiu T. Supuran
Claudiu T. Supuran University of Florence
Seik Weng Ng
Seik Weng Ng University of Malaya
Edward R. T. Tiekink
Edward R. T. Tiekink Sunway University
Daniela Vullo
Daniela Vullo University of Florence
Clemente Capasso
Clemente Capasso National Academies of Sciences, Engineering, and Medicine
Fabrizio Carta
Fabrizio Carta University of Florence
Maurizio Botta
Maurizio Botta University of Siena
Robert McKenna
Robert McKenna University of Florida

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