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Maurizio Botta

Maurizio Botta

D-Index & Metrics

Chemistry

D-Index
72
Citations
17534
World Ranking
5286
National Ranking
108

Biology and Biochemistry

D-Index
71
Citations
17164
World Ranking
6686
National Ranking
158

Overview

Maurizio Botta is affiliated with the University of Siena in Italy and conducts research primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Molecular Biology, Public Health, Environmental and Occupational Health, Insect Science, Virology, and Infectious Diseases.

The scientist's recent publications cover a range of topics and have appeared in multiple peer-reviewed journals. Notable papers include:

  • Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats, 2020, PLoS ONE
  • DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins, 2020, European Journal of Medicinal Chemistry
  • Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor, 2020, ACS Medicinal Chemistry Letters
  • DDX3 inhibitors show antiviral activity against positive-sense single-stranded RNA viruses but not against negative-sense single-stranded RNA viruses: The coxsackie B model, 2020, Antiviral Research
  • Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone, 2020, Journal of Enzyme Inhibition and Medicinal Chemistry

The scientist collaborates frequently with a specific group of co-authors, including Elena Dreassi, Annalaura Brai, Claudio Zamperini, Mattia Mori, and Francesco Saladini. These collaborations have contributed to multiple publications across various journals.

Maurizio Botta's work appears regularly in publication venues such as ACS Medicinal Chemistry Letters, European Journal of Medicinal Chemistry, PLoS ONE, International Journal of Molecular Sciences, and Antiviral Research.

The research topics that characterize their work include:

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Mosquito-borne diseases and control
  • RNA Interference and Gene Delivery
  • Insect Utilization and Effects
  • Malaria Research and Control
  • Nanoparticle-Based Drug Delivery

Best Publications

  • Modulators of 14-3-3 Protein-Protein Interactions

    Loes M. Stevers;Eline Sijbesma;Maurizio Botta;Carol MacKintosh

  • MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

    Valentina La Rosa;Giovanna Poce;Julio Ortiz Canseco;Silvia Buroni

  • Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes

    Elena Galletti;Matteo Magnani;Michela L. Renzulli;Maurizio Botta

  • Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones.

    Daniele Castagnolo;Fabrizio Manetti;Marco Radi;Beatrice Bechi

  • Crystal Structure of the OXA-48 β-Lactamase Reveals Mechanistic Diversity among Class D Carbapenemases

    Jean Denis Docquier;Vito Calderone;Vito Calderone;Filomena De Luca;Manuela Benvenuti

  • Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

    Serena Pasquini;Claudia Mugnaini;Cristina Tintori;Maurizio Botta

  • Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

    Paola Infante;Mattia Mori;Romina Alfonsi;Francesca Ghirga

  • Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies.

    Silvia Schenone;Marco Radi;Francesca Musumeci;Chiara Brullo

  • Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors.

    Roberta Barbaro;Laura Betti;Maurizio Botta;Federico Corelli

  • Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis

    Daniele Castagnolo;Alessandro De Logu;Marco Radi;Beatrice Bechi

  • Involvement of Polyamine Oxidase in Wound Healing

    Riccardo Angelini;Alessandra Tisi;Giuseppina Rea;Martha M. Chen

  • Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity.

    Mariangela Biava;Giulio Cesare Porretta;Giovanna Poce;Sibilla Supino

  • ATP-Competitive Inhibitors of mTOR: An Update

    S. Schenone;C. Brullo;F. Musumeci;M. Radi

  • Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae)

    Elena Dreassi;Annarita Cito;Assunta Zanfini;Lara Materozzi

  • Guanylated diamines, triamines, and polyamines: chemistry and biological properties.

    Daniele Castagnolo;Silvia Schenone;Maurizio Botta

  • Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.

    Maurizio Botta;Silvia Armaroli;Silvia Armaroli;Daniele Castagnolo;Gabriele Fontana

  • Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.

    Annalaura Brai;Roberta Fazi;Cristina Tintori;Claudio Zamperini

  • Antifungal Agents. 11. N-Substituted Derivatives of 1-[(Aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: Synthesis, Anti-Candida Activity, and QSAR Studies

    Roberto Di Santo;Andrea Tafi;Roberta Costi;Maurizio Botta

  • Synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity via palladium-catalyzed heteroannulation of chiral arylpropargylic alcohols

    Maurizio Botta;Vincenzo Summa;Federico Corelli;Giovanna Di Pietro

  • Antiangiogenic agents: an update on small molecule VEGFR inhibitors.

    Silvia Schenone;Francesco Bondavalli;M. Botta

  • Fibroblast growth factors and their inhibitors.

    Fabrizio Manetti;Federico Corelli;Maurizio Botta

  • A Unified and Quantitative Receptor Model for the Microtubule Binding of Paclitaxel and Epothilone

    Minmin Wang;Xiaoyang Xia;Yohan Kim;David Hwang

Frequent Co-Authors

Fabrizio Manetti
Fabrizio Manetti University of Siena
Silvia Schenone
Silvia Schenone University of Genoa
Giovanni Maga
Giovanni Maga National Research Council (CNR)
Raffaele Saladino
Raffaele Saladino Tuscia University
José A. Esté
José A. Esté Autonomous University of Barcelona
Annalisa Santucci
Annalisa Santucci University of Siena
Yves Mély
Yves Mély University of Strasbourg
Antonello Mai
Antonello Mai Sapienza University of Rome
Zeger Debyser
Zeger Debyser KU Leuven
Maurizio Zazzi
Maurizio Zazzi University of Siena

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