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Chemistry

D-Index
46
Citations
8208
World Ranking
15998
National Ranking
593

Overview

Romano Silvestri is affiliated with Sapienza University of Rome in Italy. Their research spans several fields within the biomedical sciences, notably biochemistry, genetics, and molecular biology, with a significant focus on medicine. Their work notably covers subfields such as molecular biology, organic chemistry, oncology, infectious diseases, and cell biology.

Their contributions to science include research on various topics, such as cancer-related gene regulation, synthesis and biological activity of compounds, Wnt/β-catenin signaling in development and cancer, viral gastroenteritis research and epidemiology, viral infections and immunology, cancer therapeutics and mechanisms, and computational drug discovery methods.

Romano Silvestri has published multiple papers in well-regarded journals and scientific venues. Some recent notable publications include:

  • Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection, 2023, Circulation Research
  • Modulating undruggable targets to overcome cancer therapy resistance, 2021, Drug Resistance Updates
  • Emerging Therapeutic Agents for Colorectal Cancer, 2021, Molecules
  • Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer, 2021, Biology Direct
  • Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia, 2021, European Journal of Medicinal Chemistry

Their frequent coauthors include Giuseppe La Regina, Antonio Coluccia, Michela Puxeddu, Marianna Nalli, and Domiziana Masci. Collaboration with these researchers has contributed to a range of studies reflecting interdisciplinary approaches across chemistry, biology, pharmacology, and oncology.

Romano Silvestri's work has appeared predominantly in several scientific journals, emphasizing the following venues:

  • Molecules
  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • SSRN Electronic Journal
  • European Journal of Pharmacology

Throughout their career, Romano Silvestri has maintained an extensive publication record with an emphasis on translational research that integrates molecular mechanisms and therapeutic development.

Best Publications

  • New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies

    Gabriella De Martino;Michael C. Edler;Giuseppe La Regina;Antonio Coluccia

  • Indole, a core nucleus for potent inhibitors of tubulin polymerization.

    Andrea Brancale;Romano Silvestri

  • Arylthioindoles, Potent Inhibitors of Tubulin Polymerization

    Gabriella De Martino;Giuseppe La Regina;Antonio Coluccia;Michael C. Edler

  • New Frontiers in Selective Human MAO-B Inhibitors

    Simone Carradori;Romano Silvestri

  • Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies

    Giuseppe La Regina;Michael C. Edler;Andrea Brancale;Sahar Kandil

  • Novel Indolyl Aryl Sulfones Active against HIV-1 Carrying NNRTI Resistance Mutations: Synthesis and SAR Studies

    Romano Silvestri;Gabriella De Martino;Giuseppe La Regina;Marino Artico

  • Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.

    Rino Ragno;Antonio Coluccia;Giuseppe La Regina;Gabriella De Martino

  • Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

    Romano Silvestri

  • Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide

    Giuseppe La Regina;Antonio Coluccia;Andrea Brancale;Francesco Piscitelli

  • 2-Sulfonyl-4-chloroanilino Moiety: A Potent Pharmacophore for the Anti-Human Immunodeficiency Virus Type 1 Activity of Pyrrolyl Aryl Sulfones

    Artico M;Silvestri R;Massa S;Loi Ag

  • Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.

    Marino Artico;Romano Silvestri;Eugenia Pagnozzi;Biancamaria Bruno

  • The tubulin colchicine domain: a molecular modeling perspective.

    Alberto Massarotti;Antonio Coluccia;Romano Silvestri;Giovanni Sorba

  • Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors

    Giuseppe La Regina;Ruoli Bai;Whilelmina Maria Rensen;Erica Di Cesare

  • New Pyrrole Inhibitors of Monoamine Oxidase: Synthesis, Biological Evaluation, and Structural Determinants of MAO-A and MAO-B Selectivity

    Giuseppe La Regina;Romano Silvestri;Marino Artico;Antonio Lavecchia

  • Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

    Marcella Bassetto;Tine De Burghgraeve;Leen Delang;Alberto Massarotti

  • Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects.

    Roberto Carnevale;Romano Silvestri;Lorenzo Loffredo;Marta Novo

  • New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies

    Giuseppe La Regina;Taradas Sarkar;Ruoli Bai;Michael C. Edler

  • Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.

    Rino Ragno;Marino Artico;Gabriella De Martino;Giuseppe La Regina

  • Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.

    Romano Silvestri;Marino Artico;Gabriella De Martino;Rino Ragno

  • New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

    Giuseppe La Regina;Ruoli Bai;Antonio Coluccia;Valeria Famiglini

Frequent Co-Authors

Marino Artico
Marino Artico Sapienza University of Rome
Ettore Novellino
Ettore Novellino University of Naples Federico II
Giovanni Maga
Giovanni Maga National Research Council (CNR)
Ernest Hamel
Ernest Hamel National Institutes of Health
Antonio Lavecchia
Antonio Lavecchia University of Naples Federico II
Paolo La Colla
Paolo La Colla University of Cagliari
Johan Neyts
Johan Neyts Rega Institute for Medical Research
Claudia Martini
Claudia Martini University of Pisa
Patrizia Lavia
Patrizia Lavia Sapienza University of Rome
Antonello Mai
Antonello Mai Sapienza University of Rome

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