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Chemistry
Belgium
2025
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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Chemistry

D-Index
83
Citations
22672
World Ranking
2970
National Ranking
39

Biology and Biochemistry

D-Index
86
Citations
24502
World Ranking
3000
National Ranking
45

Research.com Recognitions

  • 2025 - Research.com Chemistry in Belgium Leader Award
  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2022 - Research.com Chemistry in Belgium Leader Award

Overview

Christophe Pannecouque is affiliated with the Rega Institute for Medical Research in Belgium and has an extensive publication record focused on medicinal chemistry and antiviral drug development. Their primary research fields include Medicine and Immunology and Microbiology, with a substantial emphasis on subfields such as Infectious Diseases, Virology, Organic Chemistry, Epidemiology, and Molecular Biology.

The main topics of their work cover several areas including HIV/AIDS drug development and treatment, HIV Research and Treatment, Pneumocystis jirovecii pneumonia detection and treatment, Click Chemistry and Applications, Biochemical and Molecular Research, Chemical Synthesis and Analysis, and the Synthesis and Characterization of Heterocyclic Compounds.

Pannecouque has contributed numerous papers to a variety of publication venues. Their frequent publication outlets include the European Journal of Medicinal Chemistry with 32 publications, the Journal of Medicinal Chemistry with 27, Bioorganic Chemistry with 13, SSRN Electronic Journal with 11, and Molecules with 10 publications.

Recent notable papers include:

  • Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses, 2021, Chemical Society Reviews
  • Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties, 2020, Journal of Medicinal Chemistry
  • Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors, 2022, Journal of Medicinal Chemistry
  • Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities, 2020, Journal of Medicinal Chemistry
  • 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies, 2021, Journal of Medicinal Chemistry

Frequent co-authors in their research collaborations include:

  • Erik De Clercq
  • Dongwei Kang
  • Xinyong Liu
  • Peng Zhan
  • Fen-Er Chen

The collective research contributions of Christophe Pannecouque provide insight into the development of antiviral agents, particularly targeting HIV and related infectious diseases, combining aspects of medicinal chemistry with molecular and biochemical approaches. Their collaborative work across multiple international teams has resulted in a considerable body of literature published over several years in leading journals within the field.

Best Publications

  • Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

    Christophe Pannecouque;Dirk Daelemans;Erik De Clercq

  • Synthesis and antiviral activity of new pyrazole and thiazole derivatives

    Osama I. El-Sabbagh;Mohamed M. Baraka;Samy M. Ibrahim;Christophe Pannecouque

  • Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

    Peng Zhan;Christophe Pannecouque;Erik De Clercq;Xinyong Liu

  • Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: Implications for treatment and postexposure prophylaxis

    Myriam Witvrouw;Christophe Pannecouque;William M Switzer;Thomas M Folks

  • Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.

    Els Keyaerts;Leen Vijgen;Christophe Pannecouque;Els Van Damme

  • Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents

    Maria Letizia Barreca;Alba Chimirri;Laura De Luca;Anna-Maria Monforte

  • Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.

    Marina Kritsanida;Anastasia Mouroutsou;Panagiotis Marakos;Nicole Pouli

  • Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

    Maria L. Barreca;Jan Balzarini;Alba Chimirri;Erik De Clercq

  • Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

    Ravindra K. Rawal;Rajkamal Tripathi;S.B. Katti;Christophe Pannecouque

  • Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants.

    K. Asres;F. Bucar;T. Kartnig;M. Witvrouw

  • Chicoric acid analogues as HIV-1 integrase inhibitors.

    Zhaiwei Lin;Nouri Neamati;He Zhao;Yoshimitsu Kiryu

  • Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

    Myriam Witvrouw;Valery Fikkert;Wim Pluymers;Barry Matthews

  • Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

    Luca Sancineto;Alice Mariotti;Luana Bagnoli;Francesca Marini

  • Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

    Jalpa C. Trivedi;Jitender B. Bariwal;Kuldip D. Upadhyay;Yogesh T. Naliapara

  • Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide

    Giuseppe La Regina;Antonio Coluccia;Andrea Brancale;Francesco Piscitelli

  • A time-of-drug addition approach to target identification of antiviral compounds

    Dirk Daelemans;Rudi Pauwels;Rudi Pauwels;Erik De Clercq;Christophe Pannecouque

  • Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19

    Rosalba Perrone;Elena Butovskaya;Dirk Daelemans;Giorgio Palù

  • Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

    Dongwei Kang;Zengjun Fang;Zhenyu Li;Boshi Huang

  • Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.

    Ravindra K. Rawal;Rajkamal Tripathi;S.B. Katti;Christophe Pannecouque

  • Overview of Recent Strategic Advances in Medicinal Chemistry

    Gaochan Wu;Tong Zhao;Dongwei Kang;Jian Zhang

  • Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

    José A. Esté;Cecilia Cabrera;Dominique Schols;Peter Cherepanov

  • A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.

    Serena Massari;Dirk Daelemans;Maria Letizia Barreca;Anna Knezevich

Frequent Co-Authors

Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Jan Balzarini
Jan Balzarini KU Leuven
Xinyong Liu
Xinyong Liu Shandong University
Peng Zhan
Peng Zhan Shandong University
Zeger Debyser
Zeger Debyser KU Leuven
Anne-Mieke Vandamme
Anne-Mieke Vandamme Rega Institute for Medical Research
Robert Snoeck
Robert Snoeck KU Leuven

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