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Biology and Biochemistry

D-Index
60
Citations
11812
World Ranking
12049
National Ranking
5163

Overview

Jeffrey A. Winkles is affiliated with the University of Maryland, Baltimore in the United States. Their research focuses on the intersection of medicine, engineering, and biochemistry, with a notable emphasis on biomedical engineering and molecular biology.

The primary fields of study for this scientist include:

  • Medicine
  • Engineering
  • Biochemistry, Genetics and Molecular Biology

Within these areas, their subfields of study concentrate on:

  • Biomedical Engineering
  • Molecular Biology
  • Biomaterials
  • Oncology
  • Genetics

Jeffrey A. Winkles has contributed to multiple scientific topics, particularly in relation to cancer and nanotechnology:

  • Nanoparticle-Based Drug Delivery
  • Nanoplatforms for cancer theranostics
  • Glioma Diagnosis and Treatment
  • Ultrasound and Hyperthermia Applications
  • Cancer Cells and Metastasis
  • Graphene and Nanomaterials Applications
  • Cancer, Hypoxia, and Metabolism

Their recent publications demonstrate an active engagement in cancer therapeutics and nanomedicine:

  • Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer, 2020, Science Advances
  • Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment, 2022, Advanced Drug Delivery Reviews
  • Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials, 2024, Nano Today
  • DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts, 2022, Oncogene
  • Nanoparticle-assisted, image-guided laser interstitial thermal therapy for cancer treatment, 2022, Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology

The scientist has frequently published in the following venues:

  • Advanced Drug Delivery Reviews
  • Glia
  • Cancer Research
  • Neuro-Oncology
  • Science Advances

Collaboration appears significant in their career, with regular co-authorship alongside:

  • Graeme F. Woodworth
  • Anthony J. Kim
  • Pavlos Anastasiadis
  • Chixiang Chen

Best Publications

  • The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting.

    Jeffrey A. Winkles

  • A Novel TNF Receptor Family Member Binds TWEAK and Is Implicated in Angiogenesis

    Steven R Wiley;Linda Cassiano;Timothy Lofton;Terry Davis-Smith

  • TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor.

    Steven R Wiley;Jeffrey A Winkles;Jeffrey A Winkles

  • Endothelin-1 and Endothelin Receptor mRNA Expression in Normal and Atherosclerotic Human Arteries

    J.A. Winkles;G.F. Alberts;E. Brogi;Peter Libby

  • Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier.

    David S. Hersh;Aniket S. Wadajkar;Nathan B. Roberts;Jimena G. Perez

  • The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration.

    Rachel L. Meighan-Mantha;Debbie K.W. Hsu;Yan Guo;Sharron A.N. Brown

  • Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth.

    Katsuhisa Tanabe;Iris Bonilla;Jeffrey A. Winkles;Stephen M. Strittmatter

  • The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas

    Sheau-Line Y. Feng;Yan Guo;Valentina M. Factor;Snorri S. Thorgeirsson

  • Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase.

    Patrick J. Donohue;Gregory F. Alberts;Yan Guo;Jeffrey A. Winkles

  • TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

    Mahasweta Girgenrath;Shawn Weng;Christine A Kostek;Beth Browning

  • Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages.

    E Brogi;J A Winkles;R Underwood;S K Clinton

  • The Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK)-Fibroblast Growth Factor-inducible 14 (Fn14) Signaling System Regulates Glioma Cell Survival via NFκB Pathway Activation and BCL-XL/BCL-W Expression

    Nhan L. Tran;Wendy S. McDonough;Benjamin A. Savitch;Thomas F. Sawyer

  • Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

    Jeffrey A. Winkles;Robert Friesel;Wilson H. Burgess;Richard Howk

  • The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.

    Sharron A.N. Brown;Christine M. Richards;Heather N. Hanscom;Sheau-Line Y. Feng

  • TWEAK Is an Endothelial Cell Growth and Chemotactic Factor That Also Potentiates FGF-2 and VEGF-A Mitogenic Activity

    Patrick J. Donohue;Christine M. Richards;Sharron A.N. Brown;Heather N. Hanscom

  • Increased Fibroblast Growth Factor-Inducible 14 Expression Levels Promote Glioma Cell Invasion via Rac1 and Nuclear Factor-κB and Correlate with Poor Patient Outcome

    Nhan L. Tran;Wendy S. McDonough;Benjamin A. Savitch;Shannon P. Fortin

  • Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop

    G F Alberts;K A Peifley;A Johns;J F Kleha

  • The Human Fn14 Receptor Gene Is Up-Regulated in Migrating Glioma Cells in Vitro and Overexpressed in Advanced Glial Tumors

    Nhan L. Tran;Nhan L. Tran;Wendy S. McDonough;Wendy S. McDonough;Patrick J. Donohue;Jeffrey A. Winkles

  • FGF-1 affixation stimulates ePTFE endothelialization without intimal hyperplasia.

    John L. Gray;Steven S. Kang;Gregory C. Zenni;Dae Un Kim

  • A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase.

    P J Donohue;G F Alberts;B S Hampton;J A Winkles

Frequent Co-Authors

Michael E. Berens
Michael E. Berens Translational Genomics Research Institute
Walter N. Hittelman
Walter N. Hittelman The University of Texas MD Anderson Cancer Center
Hideo Yagita
Hideo Yagita Juntendo University
Wilson H. Burgess
Wilson H. Burgess American Red Cross
Eric C. Holland
Eric C. Holland Fred Hutchinson Cancer Research Center
Robert Friesel
Robert Friesel Maine Medical Center
Yu Cao
Yu Cao University of Minnesota
Debra J. Gilbert
Debra J. Gilbert National Institutes of Health
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center

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