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Biology and Biochemistry

D-Index
67
Citations
16964
World Ranking
8174
National Ranking
597

Overview

Klaus Strebhardt is affiliated with Goethe University Frankfurt in Germany. Their research contributions primarily span the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader areas, their work focuses on subfields including Molecular Biology, Oncology, Cancer Research, Cell Biology, and Reproductive Medicine.

Their research addresses multiple topics related to cancer biology and treatment strategies. Key themes in their work include:

  • Cancer-related Molecular Pathways
  • Microtubule and mitosis dynamics
  • Ovarian cancer diagnosis and treatment
  • Cancer, Hypoxia, and Metabolism
  • PARP inhibition in cancer therapy
  • Cell death mechanisms and regulation
  • Ubiquitin and proteasome pathways

Strebhardt's recent published papers demonstrate a focus on molecular mechanisms in cancer and therapeutic targets. Notable publications include:

  • "Caspase-8: The double-edged sword," 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • "Targeting CDK9 for Anti-Cancer Therapeutics," 2021, Cancers
  • "Non-mitotic functions of polo-like kinases in cancer cells," 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • "The role of caspase-8 in the tumor microenvironment of ovarian cancer," 2020, Cancer and Metastasis Reviews
  • "Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors," 2021, Journal of Medicinal Chemistry

Frequent publication venues for Strebhardt's work include:

  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • Cancer Communications
  • Oncogene

Collaborative work is a significant aspect of their research, with frequent co-authors being Mourad Sanhaji, Sven Becker, Monika Raab, Ranadip Mandal, and Izabela Kostova. These collaborations contribute to a diverse range of studies within cancer biology and molecular mechanisms.

Best Publications

  • Paul Ehrlich's magic bullet concept: 100 years of progress.

    Klaus Strebhardt;Axel Ullrich

  • Targeting polo-like kinase 1 for cancer therapy

    Klaus Strebhardt;Axel Ullrich

  • Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

    Nicholas W Gale;Sacha J Holland;David M Valenzuela;Ann Flenniken

  • Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

    Klaus Strebhardt

  • Polo-like kinases and oncogenesis

    Frank Eckerdt;Frank Eckerdt;Juping Yuan;Klaus Strebhardt

  • Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer.

    Georg Wolf;Robert Elez;Andreas Doermer;Uwe Holtrich

  • Effect of RNA Silencing of Polo-Like Kinase-1 (PLK1) on Apoptosis and Spindle Formation in Human Cancer Cells

    Birgit Spänkuch-Schmitt;Jürgen Bereiter-Hahn;Manfred Kaufmann;Klaus Strebhardt

  • Prognostic Significance of Polo-like Kinase (PLK) Expression in Squamous Cell Carcinomas of the Head and Neck

    R Knecht;R Elez;M Oechler;C Solbach

  • Inhibition of polo-like kinase 1 by blocking Polo-box domain-dependent protein-protein interactions

    Wolfgang Reindl;Juping Yuan;Andrea Krämer;Klaus Strebhardt

  • Trastuzumab-modified nanoparticles: optimisation of preparation and uptake in cancer cells.

    Isabel Steinhauser;Birgit Spänkuch;Klaus Strebhardt;Klaus Langer

  • PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor

    Björn Hock;Beatrix Böhme;Thomas Karn;Takaharu Yamamoto

  • Highly specific HER2-mediated cellular uptake of antibody-modified nanoparticles in tumour cells.

    Heidrun Wartlick;Kerstin Michaelis;Sabine Balthasar;Klaus Strebhardt

  • The polo‐like protein kinases Fnk and Snk associate with a Ca2+‐ and integrin‐binding protein and are regulated dynamically with synaptic plasticity

    Gunther Kauselmann;Markus Weiler;Peer Wulff;Sebastian Jessberger

  • Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells.

    Juping Yuan;Ruilan Yan;Andrea Krämer;Frank Eckerdt

  • Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

    Birgit Spänkuch-Schmitt;Georg Wolf;Christine Solbach;Sibylle Loibl

  • Identification of high risk breast-cancer patients by gene expression profiling.

    André Ahr;Thomas Karn;Christine Solbach;Tanja Seiter

  • Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease

    Lucas Kneisel;Klaus Strebhardt;August Bernd;Manfred Wolter

  • Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells

    Timo Faltus;Juping Yuan;Brigitte Zimmer;Andrea Kramer

  • Tumour cell delivery of antisense oligonuclceotides by human serum albumin nanoparticles

    Heidrun Wartlick;Birgit Spänkuch-Schmitt;Klaus Strebhardt;Jörg Kreuter

  • Polo-like kinase, a novel marker for cellular proliferation.

    J Yuan;A Hörlin;B Hock;H J Stutte

Frequent Co-Authors

Christopher E. Rudd
Christopher E. Rudd University of Montreal
Franz Rödel
Franz Rödel Goethe University Frankfurt
Claus Rödel
Claus Rödel Goethe University Frankfurt
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Bernhard Kuster
Bernhard Kuster Technical University of Munich
Jürgen Bereiter-Hahn
Jürgen Bereiter-Hahn Goethe University Frankfurt
Sibylle Loibl
Sibylle Loibl Goethe University Frankfurt
Axel Ullrich
Axel Ullrich Max Planck Institute of Biochemistry
Harald Schwalbe
Harald Schwalbe Goethe University Frankfurt
Klaus Pantel
Klaus Pantel Universität Hamburg

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