World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
81
Citations
23643
World Ranking
3242
National Ranking
240

Research.com Recognitions

  • 2001 - Fellow of Alfred P. Sloan Foundation

Overview

Harald Schwalbe is affiliated with Goethe University Frankfurt in Germany and specializes in the broader field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology. Their research spans various subfields including Infectious Diseases, Materials Chemistry, Spectroscopy, and Ecology.

The scientist's work primarily covers topics such as RNA and protein synthesis mechanisms, RNA modifications and cancer, DNA and nucleic acid chemistry, advanced biosensing and bioanalysis techniques, protein structure and dynamics, SARS-CoV-2 and COVID-19 research, and RNA research and splicing.

Frequent collaborators in their research include Christian Richter, Sridhar Sreeramulu, Anna Wacker, Boris Fürtig, and Andreas Schlundt.

Their publications appear regularly in several scientific journals, with repeated contributions to:

  • Biomolecular NMR Assignments
  • Nucleic Acids Research
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Chemistry - A European Journal

Selected recent papers authored or co-authored by Harald Schwalbe include:

  • Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy, 2020, Nucleic Acids Research
  • Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome, 2021, Angewandte Chemie International Edition
  • Folding dynamics of polymorphic G-quadruplex structures, 2021, Biopolymers
  • Cysteine oxidation and disulfide formation in the ribosomal exit tunnel, 2020, Nature Communications
  • Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation, 2021, Journal of the American Chemical Society

In recognition of their contributions, Harald Schwalbe was named a Fellow of the Alfred P. Sloan Foundation in 2001.

Best Publications

  • Long-Range Interactions Within a Nonnative Protein

    Judith Klein-Seetharaman;Maki Oikawa;Shaun B. Grimshaw;Julia Wirmer

  • NMR Spectroscopy of RNA

    Boris Fürtig;Christian Richter;Jens Wöhnert;Harald Schwalbe

  • Perspectives on NMR in drug discovery: a technique comes of age

    Maurizio Pellecchia;Ivano Bertini;David Cowburn;Claudio Dalvit

  • Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations.

    Lorna J. Smith;Kimberly A. Bolin;Harald Schwalbe;Malcolm W. MacArthur

  • Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

    Florian Buhr;Sujata Jha;Michael Thommen;Joerg Mittelstaet

  • Mechanistic insight from the crystal structure of mitochondrial complex I

    Volker Zickermann;Christophe Wirth;Hamid Nasiri;Hamid Nasiri;Karin Siegmund

  • The concept of a random coil: Residual structure in peptides and denatured proteins

    Lorna J. Smith;Klaus M. Fiebig;Harald Schwalbe;Christopher M. Dobson

  • Structure and dynamics of the homologous series of alanine peptides: a joint molecular dynamics/NMR study.

    Jürgen Graf;Phuong H. Nguyen;Gerhard Stock;Harald Schwalbe

  • Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea.

    Harald Schwalbe;Klaus M. Fiebig;Matthias Buck;Jonathan A. Jones

  • Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

    Andrea Nören-Müller;Ivan Reis-Corrêa;Heino Prinz;Claudia Rosenbaum

  • Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy

    Jan Henrik Ardenkjær-Larsen;Gregory S. Boebinger;Arnaud Comment;Simon Duckett

  • NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump.

    Bettina Elshorst;Mirko Hennig;Holger Försterling;Alexander Diener

  • Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings.

    Jens Wöhnert;Katherine J. Franz;Mark Nitz;Barbara Imperiali

  • Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90–Cdc37, a Kinome Chaperone–Cochaperone, by Triterpene Celastrol

    Sridhar Sreeramulu;Santosh Lakshmi Gande;Michael Göbel;Harald Schwalbe

  • A refined solution structure of hen lysozyme determined using residual dipolar coupling data.

    Harald Schwalbe;Shaun B. Grimshaw;Andrew Spencer;Matthias Buck

  • Three-state mechanism couples ligand and temperature sensing in riboswitches

    Anke Reining;Senada Nozinovic;Kai Schlepckow;Florian Buhr

  • Solution NMR structure of proteorhodopsin.

    Sina Reckel;Daniel Gottstein;Jochen Stehle;Frank Löhr

  • WeNMR: Structural Biology on the Grid

    Tsjerk A. Wassenaar;Marc Dijk;Nuno Loureiro-Ferreira;Gijs Schot

  • High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA

    Senada Nozinovic;Boris Fürtig;Hendrik R. A. Jonker;Christian Richter

  • NMR Characterization of Kinase p38 Dynamics in Free and Ligand-Bound Forms

    Martin Vogtherr;Krishna Saxena;Swen Hoelder;Susanne Grimme

  • Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy

    Jan-Henrik Ardenkjaer-Larsen;Gregory S. Boebinger;Arnaud Comment;Simon Duckett

Frequent Co-Authors

Christian Griesinger
Christian Griesinger Max Planck Society
Frank Löhr
Frank Löhr Goethe University Frankfurt
Judith Klein-Seetharaman
Judith Klein-Seetharaman Arizona State University
Thomas Langer
Thomas Langer Max Planck Society
Clemens Glaubitz
Clemens Glaubitz Goethe University Frankfurt
Josef Wachtveitl
Josef Wachtveitl Goethe University Frankfurt
Wolfgang Bermel
Wolfgang Bermel University of Florence
Christopher M. Dobson
Christopher M. Dobson University of Cambridge
Michael Bolte
Michael Bolte Goethe University Frankfurt

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