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Isabelle Landrieu

Isabelle Landrieu

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
8249
World Ranking
16339
National Ranking
682

Overview

Isabelle Landrieu is affiliated with the University of Lille in France and is active in research fields primarily centered on Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine.

Their research emphasizes Molecular Biology, Physiology, Cell Biology, Radiology, Nuclear Medicine and Imaging, and Cellular and Molecular Neuroscience. Key topics explored include Alzheimer's disease research and treatments, monoclonal and polyclonal antibodies research, ubiquitin and proteasome pathways, neuroscience and neuropharmacology research, cellular transport and secretion, 14-3-3 protein interactions, and computational drug discovery methods.

Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemistry
  • Zenodo (CERN European Organization for Nuclear Research)
  • Methods in Molecular Biology
  • Nature Communications

Their notable recent papers include:

  • "Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates" (2021, Frontiers in Molecular Neuroscience)
  • "Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment" (2022, Molecular Therapy)
  • "Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products" (2020, Journal of the American Chemical Society)
  • "Fragment-based Differential Targeting of PPI Stabilizer Interfaces" (2020, Journal of Medicinal Chemistry)
  • "Aggregate-selective removal of pathological tau by clustering-activated degraders" (2024, Science)

Collaboration is a significant aspect of their work, with frequent co-authors being François-Xavier Cantrelle, Elian Dupré, Luc Buée, Clément Danis, and Justine Mortelecque.

Best Publications

  • Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis

    Lieven De Veylder;Tom Beeckman;Gerrit T.S. Beemster;Luc Krols

  • Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects.

    Pascale Barbier;Orgeta Zejneli;Marlène Martinho;Alessia Lasorsa

  • Modulators of 14-3-3 Protein-Protein Interactions

    Loes M. Stevers;Eline Sijbesma;Maurizio Botta;Carol MacKintosh

  • Identification of the Tau phosphorylation pattern that drives its aggregation

    Clément Despres;Cillian Byrne;Cillian Byrne;Haoling Qi;François-Xavier Cantrelle

  • Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

    Xavier Hanoulle;Aurélie Badillo;Jean-Michel Wieruszeski;Dries Verdegem

  • Cell signaling, post-translational protein modifications and NMR spectroscopy

    Francois-Xavier Theillet;Caroline Smet-Nocca;Stamatios Liokatis;Rossukon Thongwichian

  • Structural Impact of Heparin Binding to Full-Length Tau As Studied by NMR Spectroscopy.

    Nathalie Sibille;Alain Sillen;Arnaud Leroy;Jean-Michel Wieruszeski

  • 1H NMR Study on the Binding of Pin1 Trp-trp domain with Phosphothreonine Peptides

    René Wintjens;Jean-Michel Wieruszeski;Hervé Drobecq;Pierre Rousselot-Pailley

  • Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

    Rasheduzzaman Chowdhury;Ivanhoe K. H. Leung;Ya-Min Tian;Martine I. Abboud

  • Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.

    Marie Albert;Marie Albert;Georges Mairet-Coello;Clément Danis;Clément Danis;Clément Danis;Sarah Lieger;Sarah Lieger

  • A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana

    Isabelle Landrieu;Marco da Costa;Lieven De Veylder;Frédérique Dewitte

  • Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

    Caroline Smet-Nocca;Malgorzata Broncel;Jean-Michel Wieruszeski;Caroline Tokarski

  • NMR investigation of the interaction between the neuronal protein tau and the microtubules.

    Alain Sillen;Pascale Barbier;Isabelle Landrieu;Sylvie Lefebvre

  • Mice lacking phosphatase PP2A subunit PR61/B’δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

    Justin Vijay Louis;Ellen Martens;Peter Borghgraef;Caroline Lambrecht

  • NMR Analysis of a Tau Phosphorylation Pattern

    Isabelle Landrieu;Ludovic Lacosse;Arnaud Leroy;Jean-Michel Wieruszeski

  • NMR observation of Tau in Xenopus oocytes.

    Jean-François Bodart;Jean-Michel Wieruszeski;Laziza Amniai;Arnaud Leroy

  • Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules

    Laziza Amniai;Pascale Barbier;Alain Sillen;Jean-Michel Wieruszeski

  • Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

    Dries Verdegem;Aurélie Badillo;Jean-Michel Wieruszeski;Jean-Michel Wieruszeski;Isabelle Landrieu;Isabelle Landrieu

  • Accepting its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein

    Caroline Smet;Arnaud Leroy;Alain Sillen;Jean-Michel Wieruszeski

  • Spectroscopic studies of GSK3β phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E

    Arnaud Leroy;Arnaud Leroy;Isabelle Landrieu;Isabelle Huvent;Dominique Legrand

Frequent Co-Authors

Guy Lippens
Guy Lippens Federal University of Toulouse Midi-Pyrénées
Jean-Michel Wieruszeski
Jean-Michel Wieruszeski Centre national de la recherche scientifique, CNRS
Luc Buée
Luc Buée University of Lille
Dirk Inzé
Dirk Inzé Ghent University
Luc Brunsveld
Luc Brunsveld Eindhoven University of Technology
Lieven De Veylder
Lieven De Veylder Ghent University
Dragos Horvath
Dragos Horvath University of Strasbourg
Camille Locht
Camille Locht Institut Pasteur

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