What is he best known for?
The fields of study he is best known for:
His primary areas of study are Tau protein, Alzheimer's disease, Pathology, Cell biology and Progressive supranuclear palsy.
His Tau protein research incorporates elements of Pick's disease, Neurodegeneration and Exon.
Nicolas Sergeant has researched Alzheimer's disease in several fields, including Epitope, Genetically modified mouse, Neuroscience and Amyloid.
His research investigates the connection between Pathology and topics such as Hippocampus that intersect with issues in Cortex, Kinase activity and Trinucleotide repeat expansion.
His Cell biology research incorporates themes from Genetics, Cell culture, Alternative splicing, RNA splicing and Regulation of gene expression.
Nicolas Sergeant works mostly in the field of Progressive supranuclear palsy, limiting it down to topics relating to Tauopathy and, in certain cases, Parkinsonism, Frontotemporal dementia and Dementia.
His most cited work include:
- The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease (684 citations)
- Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model (380 citations)
- Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. (251 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Tau protein, Pathology, Cell biology, Neuroscience and Phosphorylation.
His work deals with themes such as Neurodegeneration, Tauopathy, RNA splicing, Exon and Gene isoform, which intersect with Tau protein.
His Cell biology study combines topics in areas such as Genetics, Biochemistry, Presenilin and Amyloid precursor protein.
His Alternative splicing, Regulation of gene expression, Phenotype and microRNA study in the realm of Genetics connects with subjects such as Dicer.
His studies in Neuroscience integrate themes in fields like Tau pathology, Genetically modified mouse and Disease, Amyloid.
He combines subjects such as Molecular biology, PIN1 and Neuron with his study of Phosphorylation.
He most often published in these fields:
- Tau protein (33.12%)
- Pathology (23.38%)
- Cell biology (27.92%)
What were the highlights of his more recent work (between 2015-2021)?
- Sperm (7.14%)
- Andrology (4.55%)
- Neuroscience (22.08%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Sperm, Andrology, Neuroscience, Transgene and Biochemistry.
His study in Neuroscience is interdisciplinary in nature, drawing from both Tau protein, Neurodegeneration, Tauopathy and Adenosine receptor.
His Tau protein study is focused on Alzheimer's disease in general.
His Neurodegeneration research integrates issues from Mutation, Gliosis, Dementia, Myotonic dystrophy and Gene isoform.
His Transgene study integrates concerns from other disciplines, such as Apolipoprotein E, CASS4 and Focal adhesion.
His Biochemistry research is multidisciplinary, incorporating perspectives in Microtubule and Brain tissue.
Between 2015 and 2021, his most popular works were:
- A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. (102 citations)
- A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. (102 citations)
- Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. (65 citations)
In his most recent research, the most cited papers focused on:
Nicolas Sergeant mainly focuses on Transgene, Adenosine receptor, Tauopathy, Glutamate receptor and Neuroscience.
His Transgene study incorporates themes from Apolipoprotein E, CASS4 and Neurodegeneration.
His Pharmacology research extends to the thematically linked field of Adenosine receptor.
His studies deal with areas such as Hippocampal formation, Adenosine A2A receptor and Genetically modified mouse as well as Glutamate receptor.
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