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Biology and Biochemistry

D-Index
49
Citations
7844
World Ranking
18084
National Ranking
812

Overview

Denis Furling is affiliated with Université Paris Cité in France and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, with additional work in Neuroscience. Their subfields of study include Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Biomedical Engineering, and Genetics.

The research topics primarily focus on Genetic Neurodegenerative Diseases, Muscle Physiology and Disorders, Mitochondrial Function and Pathology, RNA Research and Splicing, CRISPR and Genetic Engineering, Cellular Transport and Secretion, and Exercise and Physiological Responses.

Denis Furling has published in several notable venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuromuscular Disorders
  • Nature Biomedical Engineering
  • The Journal of Physiology
  • PLoS ONE

Frequent collaborators in their work include:

  • Arnaud F. Klein
  • Mégane Lemaître
  • Arnaud Ferry
  • Geneviève Gourdon
  • Onnik Agbulut

Selected recent publications by Denis Furling demonstrate the breadth of their research interests and are as follows:

  • Alternative splicing of clathrin heavy chain contributes to the switch from coated pits to plaques (2020), published in The Journal of Cell Biology
  • Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats (2022), published in Nature Biomedical Engineering
  • Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse (2020), published in The Journal of Physiology
  • CRISPR gene editing in pluripotent stem cells reveals the function of MBNL proteins during human in vitro myogenesis (2021), published in Human Molecular Genetics
  • A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1 (2020), published in Frontiers in Genetics

Best Publications

  • Human circulating AC133+ stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle

    Yvan Torrente;Marzia Belicchi;Maurilio Sampaolesi;Federica Pisati

  • Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy.

    Susan A. M. Mulders;Walther J. A. A. van den Broek;Thurman M. Wheeler;Huib J. E. Croes

  • Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy

    Charlotte Fugier;Arnaud F Klein;Caroline Hammer;Stéphane Vassilopoulos

  • New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1)

    T. Ashizawa;I. Gonzales;N. Ohsawa;R. H. Singer

  • Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy.

    Frédérique Rau;Fernande Freyermuth;Charlotte Fugier;Jean-Philippe Villemin

  • Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle.

    Andrie Koutsoulidou;Nikolaos P Mastroyiannopoulos;Denis Furling;James B Uney

  • Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy

    Fernande Freyermuth;Frédérique Rau;Yosuke Kokunai;Thomas Linke

  • Precise small-molecule recognition of a toxic CUG RNA repeat expansion

    Suzanne G Rzuczek;Lesley A Colgan;Yoshio Nakai;Michael D Cameron

  • IGF-1 induces human myotube hypertrophy by increasing cell recruitment

    V Jacquemin;D Furling;A Bigot;G.S Butler-Browne

  • Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells

    Anna Buj-Bello;Denis Furling;Hélène Tronchère;Jocelyn Laporte

  • Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation

    Florent Hubé;Guillaume Velasco;Jérôme Rollin;Denis Furling

  • Defective satellite cells in congenital myotonic dystrophy

    D. Furling;L. Coiffier;V. Mouly;J.P. Barbet

  • Replicative aging down‐regulates the myogenic regulatory factors in human myoblasts

    Anne Bigot;Virginie Jacquemin;Florence Debacq-Chainiaux;Gillian S. Butler-Browne

  • In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts

    Marie-Catherine Le Bihan;Anne Bigot;Anne Bigot;Anne Bigot;Søren Skov Jensen;Jayne L Dennis

  • Basic Transcription Element-binding Protein (BTEB) Is a Thyroid Hormone-regulated Gene in the Developing Central Nervous System EVIDENCE FOR A ROLE IN NEURITE OUTGROWTH

    Robert J. Denver;Lydia Ouellet;Denis Furling;Akira Kobayashi

  • CRISPR/Cas9-Induced (CTG⋅CAG) n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing

    Ellen L. van Agtmaal;Laurène M. André;Marieke Willemse;Sarah A. Cumming

  • The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy.

    V. Mouly;A. Aamiri;A. Bigot;R. N. Cooper

  • Decreased levels of myotonic dystrophy protein kinase (DMPK) and delayed differentiation in human myotonic dystrophy myoblasts

    Denis Furling;Dany Lemieux;Krishan Taneja;Jack Puymirat

  • Myoblast transfer therapy: is there any light at the end of the tunnel?

    Mouly;Aamiri A;Périé S;Mamchaoui K

  • Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles.

    Ian Holt;Saloni Mittal;Denis Furling;Gillian S Butler-Browne

Frequent Co-Authors

Gillian Butler-Browne
Gillian Butler-Browne Université Paris Cité
Vincent Mouly
Vincent Mouly Université Paris Cité
Glenn E. Morris
Glenn E. Morris Keele University
Bruno Eymard
Bruno Eymard Université Paris Cité
Raphaël Porcher
Raphaël Porcher Université Paris Cité
Didier Auboeuf
Didier Auboeuf École Normale Supérieure de Lyon
Marinee Chuah
Marinee Chuah KU Leuven
Bjarne Udd
Bjarne Udd University of Helsinki
Marc Peschanski
Marc Peschanski Grenoble Alpes University

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