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Wlodzimierz J. Krzyzosiak

Wlodzimierz J. Krzyzosiak

D-Index & Metrics

Genetics

D-Index
57
Citations
9697
World Ranking
3433
National Ranking
4

Research.com Recognitions

  • 2017 - Polish Academy of Science
  • 2007 - Prize of the Foundation for Polish Science - Nagroda Fundacji na rzecz Nauki Polskiej for discovering the mechanism of selective silencing of genetic information that can lead to neurodegenerative diseases

Overview

Wlodzimierz J. Krzyzosiak is affiliated with the Polish Academy of Sciences in Poland. Their research work predominantly focuses on several intersecting domains within biochemistry, genetics, molecular biology, and neuroscience.

The main fields of study associated with Wlodzimierz J. Krzyzosiak include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

The subfields of study are:

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Key topics that characterize the scientist's work cover:

  • Genetic Neurodegenerative Diseases
  • RNA Research and Splicing
  • Mitochondrial Function and Pathology
  • CRISPR and Genetic Engineering
  • DNA Repair Mechanisms

Recent publications by Wlodzimierz J. Krzyzosiak demonstrate a focus on genetic disease mechanisms, RNA biology, and cellular molecular life processes. Notable papers include:

  • Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts (2020), published in Cellular and Molecular Life Sciences
  • RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context (2020), published in Journal of Molecular Biology
  • Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts (2020), published in Stem Cell Research

Frequent collaborators in their research include:

  • Agnieszka Fiszer
  • Adam Ciesiołka
  • Agata Ciołak
  • Emilia Kozłowska
  • Anna Stroynowska-Czerwińska

The scientist's work has been published in well-recognized journals, such as:

  • Cellular and Molecular Life Sciences
  • Journal of Molecular Biology
  • Stem Cell Research

Wlodzimierz J. Krzyzosiak has been recognized with several awards during their career. They are a recipient of the Prize of the Foundation for Polish Science awarded in 2007 for discovering the mechanism of selective silencing of genetic information that can lead to neurodegenerative diseases. Additionally, the Polish Academy of Science honored them in 2017.

Best Publications

  • Practical Aspects of microRNA Target Prediction

    T M Witkos;E Koscianska;W J Krzyzosiak

  • Nuclear speckles: molecular organization, biological function and role in disease.

    Lukasz Galganski;Martyna O. Urbanek;Wlodzimierz J. Krzyzosiak

  • Structural Features of MicroRNA (miRNA) Precursors and Their Relevance to miRNA Biogenesis and Small Interfering RNA/Short Hairpin RNA Design

    Jacek Krol;Krzysztof Sobczak;Urszula Wilczynska;Maria Drath

  • Cellular toxicity of expanded RNA repeats: focus on RNA foci

    Marzena Wojciechowska;Wlodzimierz J. Krzyzosiak

  • Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target

    Wlodzimierz J. Krzyzosiak;Krzysztof Sobczak;Marzena Wojciechowska;Agnieszka Fiszer

  • RNA structure of trinucleotide repeats associated with human neurological diseases

    Krzysztof Sobczak;Mateusz de Mezer;Gracjan Michlewski;Jacek Krol

  • CAG repeats mimic CUG repeats in the misregulation of alternative splicing

    Agnieszka Mykowska;Krzysztof Sobczak;Marzena Wojciechowska;Piotr Kozlowski

  • Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

    Mateusz de Mezer;Marzena Wojciechowska;Marek Napierala;Krzysztof Sobczak;Krzysztof Sobczak

  • Ribonuclease Dicer Cleaves Triplet Repeat Hairpins into Shorter Repeats that Silence Specific Targets

    Jacek Krol;Agnieszka Fiszer;Agnieszka Mykowska;Krzysztof Sobczak

  • Structural basis of microRNA length variety

    Julia Starega-Roslan;Jacek Krol;Edyta Koscianska;Piotr Kozlowski

  • CUG repeats present in myotonin kinase RNA form metastable "slippery" hairpins.

    Marek Napierala;Wlodzimierz J. Krzyzosiak

  • Sequence-non-specific effects of RNA interference triggers and microRNA regulators

    Marta Olejniczak;Paulina Galka;Wlodzimierz J. Krzyzosiak

  • The role of the precursor structure in the biogenesis of microRNA

    Julia Starega-Roslan;Edyta Koscianska;Piotr Kozlowski;Wlodzimierz J. Krzyzosiak

  • Trinucleotide repeats in human genome and exome

    Piotr Kozlowski;Mateusz de Mezer;Wlodzimierz J. Krzyzosiak

  • CAG Repeats Containing CAA Interruptions Form Branched Hairpin Structures in Spinocerebellar Ataxia Type 2 Transcripts

    Krzysztof Sobczak;Wlodzimierz J. Krzyzosiak

  • The role of Dicer protein partners in the processing of microRNA precursors.

    Edyta Koscianska;Julia Starega-Roslan;Wlodzimierz J. Krzyzosiak

  • Structural determinants of BRCA1 translational regulation

    Krzysztof Sobczak;Wlodzimierz J. Krzyzosiak

  • Patterns of cleavages induced by lead ions in defined RNA secondary structure motifs

    Jerzy Ciesiołka;Daniel Michałowski;Jan Wrzesinski;Jacek Krajewski

  • Characterization of the lead(II)-induced cleavages in tRNAs in solution and effect of the Y-base removal in yeast tRNAPhe

    W. J. Krzyzosiak;T. Marciniec;M. Wiewiorowski;P. Romby

  • SURVEY AND SUMMARY Sequence-non-specific effects of RNA interference triggers and microRNA regulators

    Marta Olejniczak;Paulina Galka;Wlodzimierz J. Krzyzosiak

Frequent Co-Authors

Ryszard Kierzek
Ryszard Kierzek Polish Academy of Sciences
Richard Giegé
Richard Giegé Centre national de la recherche scientifique, CNRS
Jean-Pierre Ebel
Jean-Pierre Ebel Centre national de la recherche scientifique, CNRS
Pascale Romby
Pascale Romby Centre national de la recherche scientifique, CNRS
Mariusz Jaskolski
Mariusz Jaskolski Adam Mickiewicz University in Poznań
Zofia Szweykowska-Kulinska
Zofia Szweykowska-Kulinska Adam Mickiewicz University in Poznań

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