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Kazuhiko Nakatani

Kazuhiko Nakatani

D-Index & Metrics

Chemistry

D-Index
43
Citations
8139
World Ranking
17115
National Ranking
1347

Overview

Kazuhiko Nakatani is affiliated with Osaka University in Japan and has published extensively in the fields of biochemistry, genetics, and molecular biology. Their research spans several subfields, including molecular biology, cellular and molecular neuroscience, genetics, neurology, and cancer research.

The scientist's work primarily focuses on key topics such as RNA research and splicing, RNA and protein synthesis mechanisms, genetic neurodegenerative diseases, DNA and nucleic acid chemistry, neurogenetic and muscular disorders research, DNA repair mechanisms, and RNA modifications and cancer.

Notable recent papers by Kazuhiko Nakatani include:

  • A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo, 2020, Nature Genetics
  • Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model, 2021, Nature Communications
  • FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability, 2021, Cell Reports
  • Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer, 2021, Chemical Science
  • CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral-pallidoluysian atrophy, 2021, Neurobiology of Disease

Frequent coauthors collaborating with Nakatani include:

  • Asako Murata
  • Takeshi Yamada
  • Chikara Dohno
  • T. Shibata
  • Masayuki Nakamori

The scientist's publications are often found in specialized journals related to nucleic acids and biochemical research. Frequent publication venues include:

  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemical Communications
  • Biochemistry
  • Bioorganic & Medicinal Chemistry Letters

Best Publications

  • Photoinduced DNA Cleavage via Electron Transfer: Demonstration That Guanine Residues Located 5' to Guanine Are the Most Electron-Donating Sites

    Isao Saito;Masami Takayama;Hiroshi Sugiyama;Kazuhiko Nakatani

  • Mapping of the Hot Spots for DNA Damage by One-Electron Oxidation: Efficacy of GG Doublets and GGG Triplets as a Trap in Long-Range Hole Migration

    Isao Saito;Takashi Nakamura;Kazuhiko Nakatani;Yasunori Yoshioka

  • Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance.

    Kazuhiko Nakatani;Shinsuke Sando;Isao Saito

  • Recognition of a single guanine bulge by 2-acylamino-1,8-naphthyridine

    Kazuhiko Nakatani;and Shinsuke Sando;Isao Saito

  • Small-molecule ligand induces nucleotide flipping in (CAG) n trinucleotide repeats

    Kazuhiko Nakatani;Kazuhiko Nakatani;Kazuhiko Nakatani;Shinya Hagihara;Yuki Goto;Akio Kobori

  • Chemistry of Sequence-Dependent Remote Guanine Oxidation: Photoreaction of Duplex DNA Containing Cyanobenzophenone-Substituted Uridine

    Kazuhiko Nakatani;Chikara Dohno;Isao Saito

  • Modulation of DNA-mediated hole-transport efficiency by changing superexchange electronic interaction

    Kazuhiko Nakatani;and Chikara Dohno;Isao Saito

  • A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

    Masayuki Nakamori;Gagan B. Panigrahi;Stella Lanni;Terence Gall-Duncan

  • Recognition of Guanine−Guanine Mismatches by the Dimeric Form of 2-Amino-1,8-naphthyridine

    Kazuhiko Nakatani;Shinsuke Sando;Hiroyuki Kumasawa;Jun Kikuchi

  • Photoswitchable molecular glue for DNA.

    Chikara Dohno;Shin-Nosuke Uno;Kazuhiko Nakatani

  • Improved selectivity for the binding of naphthyridine dimer to guanine-guanine mismatch.

    Kazuhiko Nakatani;Shinusuke Sando;Isao Saito

  • Chemistry Challenges in SNP Typing

    Kazuhiko Nakatani

  • The SPR sensor detecting cytosine-cytosine mismatches

    Akio Kobori;Souta Horie;Hitoshi Suda;Isao Saito

  • Photophysics of the intramolecular exciplex formation in .omega.-(1-pyrenyl)-.alpha.-(dimethylamino)alkanes

    A. M. Swinnen;M. Van der Auweraer;F. C. De Schryver;K. Nakatani

  • Binding of naphthyridine carbamate dimer to the (CGG)n repeat results in the disruption of the G-C base pairing.

    Tao Peng;Kazuhiko Nakatani

  • Detection of guanine–adenine mismatches by surface plasmon resonance sensor carrying naphthyridine–azaquinolone hybrid on the surface

    Shinya Hagihara;Hiroyuki Kumasawa;Yuki Goto;Gosuke Hayashi

  • HIGHLY EFFICIENT PHOTOCHEMICAL GENERATION OF O-QUINONE METHIDE FROM MANNICH BASES OF PHENOL DERIVATIVES

    Kazuhiko Nakatani;Nobuhiro Higashida;Isao Saito

  • Fluorescent indicator displacement assay for ligand-RNA interactions.

    Jinhua Zhang;Shiori Umemoto;Kazuhiko Nakatani

  • Mismatch-binding ligands function as a molecular glue for DNA.

    Tao Peng;Chikara Dohno;Kazuhiko Nakatani

  • DNA alkylation properties of the duocarmycins: (+)-duocarmycin A, epi-(+)-duocarmycin A, ent-(−)-duocarmycin A and epi,ent-(−)-duocarmycin A

    Dale L. Boger;Weiya Yun;Shiro Terashima;Yasumichi Fukuda

Frequent Co-Authors

Isao Saito
Isao Saito Kyoto University
Takeji Takui
Takeji Takui Osaka Metropolitan University
Yoshitaka Nagai
Yoshitaka Nagai Osaka University
Kazunobu Sato
Kazunobu Sato Osaka Metropolitan University
Christopher E. Pearson
Christopher E. Pearson University of Toronto
Zhi-Hong Jiang
Zhi-Hong Jiang Macau University of Science and Technology
Tadashi Okada
Tadashi Okada Osaka University
Kizashi Yamaguchi
Kizashi Yamaguchi Osaka University
Justin Jang Hann Chu
Justin Jang Hann Chu National University of Singapore
Daisuke Shiomi
Daisuke Shiomi Osaka Metropolitan University

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