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Biology and Biochemistry

D-Index
70
Citations
16797
World Ranking
7036
National Ranking
3237

Overview

Matthew D. Disney is affiliated with the Scripps Research Institute in the United States. Their research primarily focuses on the biochemical and molecular mechanisms underlying RNA and protein synthesis, with extensive contributions in the fields of molecular biology, cellular and molecular neuroscience, cardiology and cardiovascular medicine, genetics, and cancer research.

The scientist has published extensively in areas related to RNA biology, particularly exploring RNA structures, RNA modifications in cancer, RNA interference, gene delivery, and neurogenetic as well as muscular disorders. Their work also covers viral infections and immunology research.

Recent papers authored or coauthored by Matthew D. Disney include:

  • Targeting RNA structures with small molecules, 2022, Nature Reviews Drug Discovery
  • Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders, 2020, ACS Central Science
  • Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer, 2020, Proceedings of the National Academy of Sciences
  • Small molecule recognition of disease-relevant RNA structures, 2020, Chemical Society Reviews
  • How We Think about Targeting RNA with Small Molecules, 2020, Journal of Medicinal Chemistry

Frequent collaborators include Jessica L. Childs-Disney, Yuquan Tong, Amirhossein Taghavi, Samantha M. Meyer, and Raphael I. Benhamou. Their collaborations have contributed to a significant body of work within the RNA research domain.

Matthew D. Disney has published largely in respected venues, with multiple publications in:

  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Chemical Biology
  • Proceedings of the National Academy of Sciences
  • Journal of Medicinal Chemistry

Their main fields of study are categorized under Biochemistry, Genetics, and Molecular Biology, with specific focus areas such as molecular biology, neuroscience, cardiology, genetics, and cancer. The scientist's research topics emphasize RNA and protein synthesis mechanisms, RNA research and splicing, RNA modifications related to cancer, RNA interference, genetic neurodegenerative diseases, viral infections and immunology, as well as neurogenetic and muscular disorders.

Best Publications

  • Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure

    David H. Mathews;Matthew D. Disney;Jessica L. Childs;Susan J. Schroeder

  • Detection of Bacteria with Carbohydrate-Functionalized Fluorescent Polymers

    Matthew D. Disney;Juan Zheng;Timothy M. Swager;Peter H. Seeberger

  • The Use of Carbohydrate Microarrays to Study Carbohydrate-Cell Interactions and to Detect Pathogens

    Matthew D. Disney;Peter H. Seeberger

  • A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA

    Rita L Strack;Matthew D Disney;Samie R Jaffrey

  • Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

    Zhaoming Su;Yongjie Zhang;Tania F. Gendron;Peter O. Bauer

  • Sequence-based design of bioactive small molecules that target precursor microRNAs

    Sai Pradeep Velagapudi;Steven M Gallo;Matthew D Disney

  • Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

    Dilek Colak;Nikica Zaninovic;Michael S. Cohen;Zev Rosenwaks

  • Hybridization-Based Unquenching of DNA Hairpins on Au Surfaces: Prototypical “Molecular Beacon” Biosensors

    Hui Du;Matthew D Disney;Benjamin L Miller;Todd D Krauss

  • Recent advances in developing small molecules targeting RNA

    Lirui Guan;Matthew D. Disney

  • Tools for glycomics : mapping interactions of carbohydrates in biological systems

    Daniel M. Ratner;Eddie W. Adams;Matthew D. Disney;Matthew D. Disney;Peter H. Seeberger;Peter H. Seeberger

  • Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

    Tania D Gendron;Jeannie Chew;Jeannette N. Stankowski;Lindsey R. Hayes

  • Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome

    Chantal Sellier;Fernande Freyermuth;Ricardos Tabet;Tuan Tran

  • Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3

    Alexei Pushechnikov;Melissa M. Lee;Jessica L. Childs-Disney;Krzysztof Sobczak

  • Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

    Matthew D. Disney

  • Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

    Matthew D. Disney;Audrey M. Winkelsas;Sai Pradeep Velagapudi;Mark Southern

  • Design of a small molecule against an oncogenic noncoding RNA

    Sai Pradeep Velagapudi;Michael D. Cameron;Christopher L. Haga;Laura H. Rosenberg

  • Precise small-molecule recognition of a toxic CUG RNA repeat expansion

    Suzanne G Rzuczek;Lesley A Colgan;Yoshio Nakai;Michael D Cameron

  • Small molecule targeted recruitment of a nuclease to rna

    Matthew D. Disney

  • A mannan binding lectin is involved in cell–cell attachment in a toxic strain of Microcystis aeruginosa

    Jan Christoph Kehr;Yvonne Zilliges;Andreas Springer;Matthew D. Disney

  • Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit

    Matthew G. Costales;Christopher L. Haga;Sai Pradeep Velagapudi;Jessica L. Childs-Disney

Frequent Co-Authors

Peter H. Seeberger
Peter H. Seeberger Max Planck Society
Douglas H. Turner
Douglas H. Turner University of Rochester
Charles A. Thornton
Charles A. Thornton University of Rochester Medical Center
Eric T. Wang
Eric T. Wang University of Florida
Tania F. Gendron
Tania F. Gendron Mayo Clinic
George C. Schatz
George C. Schatz Northwestern University
Donald G. Phinney
Donald G. Phinney Scripps Research Institute
Jeffrey D. Rothstein
Jeffrey D. Rothstein Johns Hopkins University

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