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Christopher E. Pearson

Christopher E. Pearson

D-Index & Metrics

Genetics

D-Index
60
Citations
23454
World Ranking
3109
National Ranking
114

Overview

Christopher E. Pearson is affiliated with the University of Toronto in Canada. Their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Within these areas, their subfields of study include Molecular Biology, Cellular and Molecular Neuroscience, Genetics, Neurology, and Cardiology and Cardiovascular Medicine.

The scientist's body of work covers a range of main topics, including Genetic Neurodegenerative Diseases, DNA Repair Mechanisms, Genetics and Neurodevelopmental Disorders, RNA Research and Splicing, Mitochondrial Function and Pathology, Genomics and Rare Diseases, and Genomic variations and chromosomal abnormalities.

Christopher E. Pearson has contributed to numerous publications. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Journal of Huntington s Disease
  • Frontiers in Genetics
  • Science Advances

Notable recent papers by Pearson include:

  • "Genome-wide detection of tandem DNA repeats that are expanded in autism" (2020, Nature)
  • "A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo" (2020, Nature Genetics)
  • "Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum" (2024, Nature Genetics)
  • "Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences" (2021, Genome Research)
  • "Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies" (2020, The Lancet Neurology)

Collaboration is a significant aspect of Pearson's research activities. Their frequent co-authors include Mahreen Khan, Terence Gall-Duncan, Ryan K. C. Yuen, Amit Laxmikant Deshmukh, and Mohiuddin Mohiuddin.

Best Publications

  • Table S2: Trans-factors and trinucleotide repeat instability Trans-factor

    Arturo López Castel;John D Cleary;Christopher E Pearson

  • DNA Structure and Function

    Richard R. Sinden;Christopher E. Pearson;Vladimir N. Potaman;David W. Ussery

  • Repeat instability: mechanisms of dynamic mutations

    Christopher E. Pearson;Kerrie Nichol Edamura;John D. Cleary

  • Repeat instability as the basis for human diseases and as a potential target for therapy

    Arturo López Castel;John D. Cleary;John D. Cleary;Christopher E. Pearson;Christopher E. Pearson

  • RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.

    Peng Jin;Daniela C. Zarnescu;Fuping Zhang;Christopher E. Pearson

  • Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

    Adam Shlien;Brittany B Campbell;Richard de Borja;Ludmil B Alexandrov

  • The Disease-associated r(GGGGCC)n Repeat from the C9orf72 Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures

    Kaalak Reddy;Bita Zamiri;Sabrina Y.R. Stanley;Robert B. Macgregor

  • Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci.

    Christopher E. Pearson;Richard R. Sinden

  • New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1)

    T. Ashizawa;I. Gonzales;N. Ohsawa;R. H. Singer

  • Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

    Christopher E Pearson;Richard R Sinden

  • Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

    Ricardo Mouro Pinto;Ella Dragileva;Andrew Kirby;Andrew Kirby;Alejandro Lloret

  • Disease-associated repeat instability and mismatch repair

    Monika H.M. Schmidt;Christopher E. Pearson

  • Genome-wide detection of tandem DNA repeats that are expanded in autism.

    Brett Trost;Worrawat Engchuan;Charlotte M. Nguyen;Charlotte M. Nguyen;Bhooma Thiruvahindrapuram

  • Evidence of cis -acting factors in replication-mediated trinucleotide repeat instability in primate cells

    John D. Cleary;Kerrie Nichol;Yuh-Hwa Wang;Christopher E. Pearson

  • Inverted repeats, stem‐loops, and cruciforms: Significance for initiation of DNA replication

    Christopher E. Pearson;Haralabos Zorbas;Gerald B. Price;Maria Zannis-Hadjopoulos

  • TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)n Repeat of the C9orf72 Gene and Blocks Interaction of RNA-binding Proteins *

    Bita Zamiri;Kaalak Reddy;Robert B. Macgregor;Christopher E. Pearson

  • Peer-to-peer file sharing system and method using user datagram protocol

    Christopher Pearson

  • Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair.

    Gagan B Panigrahi;Rachel Lau;S Erin Montgomery;Michelle R Leonard

  • Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA.

    Richard R. Sinden;Vladimir N. Potaman;Elena A. Oussatcheva;Christopher E. Pearson

  • Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation

    Christopher E. Pearson;Evan E. Eichler;Diego Lorenzetti;Shannon F. Kramer

Frequent Co-Authors

Richard R. Sinden
Richard R. Sinden South Dakota School of Mines and Technology
Charles A. Thornton
Charles A. Thornton University of Rochester Medical Center
David Chitayat
David Chitayat University of Toronto
Albert R. La Spada
Albert R. La Spada University of California, Irvine
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Darren G. Monckton
Darren G. Monckton University of Glasgow
Alan E. Tomkinson
Alan E. Tomkinson University of New Mexico
Glenn E. Morris
Glenn E. Morris Keele University
Uri Tabori
Uri Tabori University of Toronto
Eric Bouffet
Eric Bouffet University of Toronto

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