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Genetics

D-Index
50
Citations
9426
World Ranking
3934
National Ranking
456

Overview

Darren G. Monckton is affiliated with the University of Glasgow in the United Kingdom. Their research activity spans a range of topics primarily centered on genetic neurodegenerative diseases, with significant contributions to understanding Huntington's disease and related molecular pathways.

The scientist's research encompasses several main fields of study including Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. More specifically, their work delves into subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, and Radiology, Nuclear Medicine and Imaging, with a focused interest in Genetics as well.

Key research topics tackled by Darren G. Monckton include:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Parkinson's Disease Mechanisms and Treatments
  • DNA Repair Mechanisms
  • Neurological disorders and treatments
  • Muscle Physiology and Disorders
  • Fungal and yeast genetics research

Their frequent publication venues reflect a consistent presence in specialized journals and platforms, namely:

  • Neuromuscular Disorders
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Huntington s Disease
  • Human Molecular Genetics
  • Neurology Genetics

Darren G. Monckton's recent papers include:

  • "Huntington's Disease Pathogenesis: Two Sequential Components" (2021) published in Journal of Huntington s Disease
  • "Genetic modifiers of Huntington disease differentially influence motor and cognitive domains" (2022) in The American Journal of Human Genetics
  • "DNA methylation study of Huntington's disease and motor progression in patients and in animal models" (2020) in Nature Communications
  • "Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects" (2020) in The American Journal of Human Genetics
  • "Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset" (2022) in Nature Neuroscience

The scientist has collaborated frequently with several co-authors over their career. Those who have contributed notably include Marc Ciosi, Sarah A. Cumming, Jeffrey D. Long, Peter Holmans, and Lesley Jones, each with numerous joint publications.

Best Publications

  • Complex gene conversion events in germline mutation at human minisatellites

    Alec J. Jeffreys;Keiji Tamaki;Annette MacLeod;Darren G. Monckton;Darren G. Monckton

  • Minisatellite repeat coding as a digital approach to DNA typing

    Alec J. Jeffreys;Annette MacLeod;Keiji Tamaki;David L. Neil

  • CAG repeat not polyglutamine length determines timing of Huntington’s disease onset

    Jong-Min Lee;Kevin Correia;Jacob Loupe;Kyung-Hee Kim

  • Somatic mosaicism, germline expansions, germline reversions and intergenerational reductions in myotonic dystrophy males: small pool PCR analyses

    D. G. Monckton;L. J C Wong;T. Ashizawa;C. T. Caskey

  • New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1)

    T. Ashizawa;I. Gonzales;N. Ohsawa;R. H. Singer

  • Myotonic dystrophy: an unstable CTG repeat in a protein kinase gene.

    L Timchenko;D G Monckton;C T Caskey;C T Caskey

  • Somatic heterogeneity of the CTG repeat in myotonic dystrophy is age and size dependent.

    L. J C Wong;T. Ashizawa;D. G. Monckton;C. T. Caskey

  • Pms2 is a genetic enhancer of trinucleotide CAG·CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion

    Mário Gomes-Pereira;M. Teresa Fortune;Laura Ingram;John P. McAbney

  • Somatic instability of the expanded CTG triplet repeat in myotonic dystrophy type 1 is a heritable quantitative trait and modifier of disease severity

    Fernando Morales;Jillian M. Couto;Catherine F. Higham;Grant Hogg

  • Progression of Somatic CTG Repeat Length Heterogeneity in the Blood Cells of Myotonic Dystrophy Patients

    Loreto Martorell;Darren G. Monckton;José Gamez;Keith J. Johnson

  • Consensus-based care recommendations for adults with myotonic dystrophy type 1.

    Tetsuo Ashizawa;Cynthia Gagnon;William J. Groh;Laurie Gutmann

  • MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.

    Stéphanie Tomé;Kevin Manley;Kevin Manley;Jodie P. Simard;Greg W. Clark;Greg W. Clark

  • Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability

    M. Teresa Fortune;Christos Vassilopoulos;Mary I. Coolbaugh;Michael J. Siciliano

  • MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

    Michael Flower;Vilija Lomeikaite;Marc Ciosi;Sarah Cumming

  • Cis-acting modifiers of expanded CAG/CTG triplet repeat expandability: associations with flanking GC content and proximity to CpG islands.

    Graham J. R. Brock;Niall H. Anderson;Darren G. Monckton

  • Hypermutable myotonic dystrophy CTG repeats in transgenic mice

    Monckton Dg;Coolbaugh Mi;Ashizawa Kt;Siciliano Mj

  • CRISPR/Cas9-Induced (CTG⋅CAG) n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing

    Ellen L. van Agtmaal;Laurène M. André;Marieke Willemse;Sarah A. Cumming

  • A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes

    Marc Ciosi;Alastair Maxwell;Sarah A. Cumming;Davina J. Hensman Moss

  • Minisatellite mutation rate variation associated with a flanking DNA sequence polymorphism.

    Darren G. Monckton;Darren G. Monckton;Rita Neumann;Tara Guram;Neale Fretwell

  • Variant CCG and GGC repeats within the CTG expansion dramatically modify mutational dynamics and likely contribute toward unusual symptoms in some myotonic dystrophy type 1 patients

    Claudia Braida;Rhoda K.A. Stefanatos;Berit Adam;Navdeep Mahajan

Frequent Co-Authors

Lesley Jones
Lesley Jones Cardiff University
Peter Holmans
Peter Holmans Cardiff University
Marcy E. MacDonald
Marcy E. MacDonald Harvard University
Jeffrey D. Long
Jeffrey D. Long University of Iowa
Alec J. Jeffreys
Alec J. Jeffreys University of Leicester
Hanns Lochmüller
Hanns Lochmüller University of Freiburg
James F. Gusella
James F. Gusella Harvard University
Tetsuo Ashizawa
Tetsuo Ashizawa Houston Methodist
Benedikt Schoser
Benedikt Schoser Ludwig-Maximilians-Universität München
Michael Orth
Michael Orth University of Ulm

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