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D-Index
66
Citations
30762
World Ranking
2569
National Ranking
329

Overview

Lesley Jones is affiliated with Cardiff University in the United Kingdom and has contributed extensively to the fields of biochemistry, genetics, molecular biology, neuroscience, and medicine. Their research primarily focuses on genetic neurodegenerative diseases, with a special emphasis on Huntington's disease and related neurological disorders.

Their body of work includes 28 publications in molecular biology, 25 in cellular and molecular neuroscience, and 13 in neurology, demonstrating a multidisciplinary approach to understanding complex biological systems. The main topics covered in their research include:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Neurological Disorders and Treatments
  • Fungal and Yeast Genetics Research
  • Parkinson's Disease Mechanisms and Treatments
  • DNA Repair Mechanisms
  • Ubiquitin and Proteasome Pathways

Jones has published in a variety of journals, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Huntington's Disease
  • Neurology
  • The American Journal of Human Genetics
  • Nature Neuroscience

Among notable recent papers are:

  • "Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease" (2021) published in Neurology
  • "Huntington's Disease Pathogenesis: Two Sequential Components" (2021) published in Journal of Huntington's Disease
  • "Genetic modifiers of Huntington disease differentially influence motor and cognitive domains" (2022) published in The American Journal of Human Genetics
  • "Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects" (2020) published in The American Journal of Human Genetics
  • "Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset" (2022) published in Nature Neuroscience

The scientist has collaborated frequently with colleagues such as Peter Holmans, Branduff McAllister, Thomas H. Massey, James F. Gusella, and Jong-Min Lee, indicating active engagement in collaborative research on neurodegenerative diseases and genetic factors affecting Huntington's disease.

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Huntington's disease

    Gillian Bates;K P S J Murphy;P Harper;L Jones

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Regional and cellular gene expression changes in human Huntington's disease brain.

    Angela Kaye Hodges;Andrew D. Strand;Aaron K. Aragaki;Alexandre Kuhn

  • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

    Lesley Jones;Peter A. Holmans;Marian L. Hamshere;Denise Harold

  • The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.

    Amy N. Packer;Yi Xing;Scott Q. Harper;Lesley Jones

  • Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

    Jong-Min Lee;Vanessa C. Wheeler;Michael J. Chao;Jean Paul G. Vonsattel

  • Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.

    Yapeng Su;Daniel Chen;Dan Yuan;Christopher Lausted

  • CAG repeat not polyglutamine length determines timing of Huntington’s disease onset

    Jong-Min Lee;Kevin Correia;Jacob Loupe;Kyung-Hee Kim

  • Susceptibility Locus for Alzheimer's Disease on Chromosome 10

    Amanda Myers;Peter Holmans;Helen Marshall;Jennifer Kwon

  • Transgenic rat model of Huntington's disease

    Stephan von Hörsten;Ina Schmitt;Huu Phuc Nguyen;Carsten Holzmann

  • Common polygenic variation enhances risk prediction for Alzheimer's disease.

    Valentina Escott-Price;Rebecca Sims;Christian Bannister;Denise Harold

  • Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

    Davina J Hensman Moss;Antonio F Pardiñas;Douglas Langbehn;Kitty Lo

  • A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter

    G. Spurlock;A. Heils;Peter Alan Holmans;J. Williams

  • A novel Alzheimer disease locus located near the gene encoding tau protein

    G. Jun;C. A. Ibrahim-Verbaas;M. Vronskaya;J-C Lambert;J-C Lambert;J-C Lambert

  • Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

    Alexandre Kuhn;Darlene R. Goldstein;Angela Hodges;Angela Hodges;Andrew D. Strand

  • Expanded CAG repeats in schizophrenia and bipolar disorder.

    Michael Conlon O'Donovan;Carol Guy;Nicholas John Craddock;Kevin Murphy

  • Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

    Lesley Jones;Darlene R. Goldstein;Gareth P. Hughes;Andrew Strand

Frequent Co-Authors

Peter Holmans
Peter Holmans Cardiff University
Michael John Owen
Michael John Owen Cardiff University
Julie Williams
Julie Williams Cardiff University
Michael Conlon O'Donovan
Michael Conlon O'Donovan Cardiff University
Stephen B. Dunnett
Stephen B. Dunnett Cardiff University
Simon Lovestone
Simon Lovestone University of Oxford
Marcy E. MacDonald
Marcy E. MacDonald Harvard University
John Hardy
John Hardy University College London
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Denise Harold
Denise Harold Dublin City University

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