2026 Alan E. Tomkinson: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	74	1238	1102	638	554	165	17475

Overview

Alan E. Tomkinson is affiliated with the University of New Mexico in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with primary subfields including Molecular Biology, Oncology, and Structural Biology.

The scientist's work focuses extensively on DNA repair mechanisms, which constitutes the main topic of their research. Additional key research topics include PARP inhibition in cancer therapy, advanced electron microscopy techniques and applications, CRISPR and genetic engineering, advanced biosensing and bioanalysis techniques, cancer therapeutics and mechanisms, and genomics and chromatin dynamics.

Frequent collaborators in their research encompass Tasmin Naila, Seema Khattri Bhandari, Aleksandr Sverzhinsky, John M. Pascal, and Susan P. Lees-Miller.

Alan E. Tomkinson has published multiple papers in notable scientific venues. Prominent publication venues include Nucleic Acids Research, DNA Repair, Journal of Molecular Biology, bioRxiv (Cold Spring Harbor Laboratory), and Nature.

Some of the recent publications authored or co-authored by Alan E. Tomkinson are:

Structural basis of long-range to short-range synaptic transition in NHEJ, 2021, Nature
Human DNA ligases in replication and repair, 2020, DNA Repair
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells, 2020, NAR Cancer
Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers, 2021, Theranostics
An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex, 2020, Nucleic Acids Research

Best Publications

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.

Gopal K. Dasika;Suh Chin J. Lin;Song Zhao;Patrick Sung

581
Citations
AP endonuclease-independent DNA base excision repair in human cells

Lee R Wiederhold;John B. Leppard;Padmini Kedar;Feridoun Karimi-Busheri

551
Citations
Mammalian Abasic Site Base Excision Repair: IDENTIFICATION OF THE REACTION SEQUENCE AND RATE-DETERMINING STEPS *

Deepak K. Srivastava;Brian J. Vande Berg;Rajendra Prasad;James T. Molina

479
Citations
Human DNA ligase I completely encircles and partially unwinds nicked DNA.

John M. Pascal;Patrick J. O'Brien;Patrick J. O'Brien;Alan E. Tomkinson;Tom Ellenberger

451
Citations
Reconstitution of 5'-directed human mismatch repair in a purified system.

Yanbin Zhang;Fenghua Yuan;Steven R. Presnell;Keli Tian

436
Citations
Eukaryotic DNA ligases: structural and functional insights.

Tom Ellenberger;Alan E. Tomkinson

435
Citations
Mechanism of DNA double-strand break repair by non-homologous end joining.

Melissa L. Hefferin;Alan E. Tomkinson

434
Citations
Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes.

Ling Chen;Kelly Trujillo;William Ramos;Patrick Sung

401
Citations
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

Hind Ghezraoui;Marion Piganeau;Marion Piganeau;Benjamin Renouf;Benjamin Renouf;Jean Baptiste Renaud;Jean Baptiste Renaud

376
Citations
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.

Deborah E. Barnes;Alan E. Tomkinson;Alan R. Lehmann;A.David B. Webster

368
Citations
Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease

AJ Bardwell;L Bardwell;L Bardwell;AE Tomkinson;EC Friedberg

342
Citations
DNA ligases: structure, reaction mechanism, and function.

Alan E. Tomkinson;Sangeetha Vijayakumar;John M. Pascal;Tom Ellenberger

339
Citations
An interaction between DNA ligase I and proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining

David S. Levin;Wei Bai;Nina Yao;Michael O’Donnell

337
Citations
Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis

Rajendra Prasad;Rakesh K. Singhal;Deepak K. Srivastava;James T. Molina

333
Citations
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.

Ling Chen;Kelly Trujillo;Patrick Sung;Alan E. Tomkinson

333
Citations
Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

John B. Leppard;Zhiwan Dong;Zachary B. Mackey;Alan E. Tomkinson

304
Citations
Mycobacterial Ku and Ligase Proteins Constitute a Two-Component NHEJ Repair Machine

Marina Della;Phillip L. Palmbos;Hui Min Tseng;Louise M. Tonkin;Louise M. Tonkin

293
Citations
Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.

David S. Levin;Allison E. McKenna;Teresa A. Motycka;Yoshihiro Matsumoto

290
Citations
XRCC1 co‐localizes and physically interacts with PCNA

Jinshui Fan;Marit Otterlei;Heng‐Kuan Wong;Alan E. Tomkinson

288
Citations
Structure and function of mammalian DNA ligases

Alan E Tomkinson;Zachary B Mackey

264
Citations

Frequent Co-Authors

Tom Ellenberger Washington University in St. Louis

Sankar Mitra Houston Methodist

John A. Tainer The University of Texas MD Anderson Cancer Center

Tapas K. Hazra The University of Texas Medical Branch at Galveston

David M. Wilson AstraZeneca (United Kingdom)

Istvan Boldogh The University of Texas Medical Branch at Galveston

Guo Min Li The University of Texas Southwestern Medical Center

Susan P. Lees-Miller University of Calgary

Susan S. Wallace University of Vermont

Christopher E. Pearson University of Toronto

External Links

Personal website of Alan E. Tomkinson

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