His scientific interests lie mostly in DNA ligase, DNA repair, Nucleotide excision repair, Molecular biology and DNA clamp. His research integrates issues of Processivity, Polymerase and Cell biology in his study of DNA ligase. His DNA repair study deals with DNA damage intersecting with Exonuclease and Primase.
His Molecular biology study incorporates themes from Base excision repair, AP endonuclease, DNA glycosylase and AP site. His DNA clamp research is multidisciplinary, incorporating elements of Okazaki fragments, DNA polymerase II, HMG-box and DNA replication. His research integrates issues of DNA polymerase delta and DNA polymerase I in his study of Okazaki fragments.
Alan E. Tomkinson spends much of his time researching DNA ligase, DNA repair, Molecular biology, DNA replication and Biochemistry. His DNA ligase research incorporates themes from DNA polymerase mu, DNA clamp and Cell biology. His DNA repair research is multidisciplinary, incorporating perspectives in Cancer research and DNA damage.
His research in Molecular biology intersects with topics in Replication protein A, Non-homologous end joining, Replication factor C, DNA mismatch repair and DNA ligase activity. His DNA replication study integrates concerns from other disciplines, such as DNA polymerase delta and Proliferating cell nuclear antigen. His Base excision repair research includes elements of Computational biology and AP site.
DNA ligase, Cell biology, DNA repair, DNA replication and DNA are his primary areas of study. The DNA ligase study combines topics in areas such as DDB1 and LIG4. Within one scientific family, Alan E. Tomkinson focuses on topics pertaining to DNA repair protein XRCC4 under Cell biology, and may sometimes address concerns connected to Ku80 and Non-homologous end joining.
His studies in DNA repair integrate themes in fields like DNA polymerase mu and Mitochondrial DNA. His DNA replication research includes themes of Molecular biology, DNA clamp and Proliferating cell nuclear antigen. His work on Homologous recombination and Polymerase is typically connected to XRCC1 as part of general DNA study, connecting several disciplines of science.
Alan E. Tomkinson mainly focuses on DNA ligase, Cell biology, DNA damage, Genetics and DNA replication. His DNA ligase study is concerned with Biochemistry in general. Alan E. Tomkinson has included themes like Chromatin and DNA in his Cell biology study.
As part of the same scientific family, Alan E. Tomkinson usually focuses on DNA damage, concentrating on DNA polymerase and intersecting with Genome instability, Cancer cell, Cancer and DNA polymerase II. He has researched DNA replication in several fields, including Molecular biology, MSH2 and Trinucleotide repeat expansion. His Molecular biology research is multidisciplinary, relying on both DNA repair, Control of chromosome duplication, Licensing factor and Eukaryotic DNA replication.
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AP endonuclease-independent DNA base excision repair in human cells
Lee R Wiederhold;John B. Leppard;Padmini Kedar;Feridoun Karimi-Busheri.
Molecular Cell (2004)
Human DNA ligase I completely encircles and partially unwinds nicked DNA.
John M. Pascal;Patrick J. O'Brien;Patrick J. O'Brien;Alan E. Tomkinson;Tom Ellenberger.
Mechanism of DNA double-strand break repair by non-homologous end joining.
Melissa L. Hefferin;Alan E. Tomkinson.
DNA Repair (2005)
Reconstitution of 5'-directed human mismatch repair in a purified system.
Yanbin Zhang;Fenghua Yuan;Steven R. Presnell;Keli Tian.
Eukaryotic DNA ligases: structural and functional insights.
Tom Ellenberger;Alan E. Tomkinson.
Annual Review of Biochemistry (2008)
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Hind Ghezraoui;Marion Piganeau;Marion Piganeau;Benjamin Renouf;Benjamin Renouf;Jean Baptiste Renaud;Jean Baptiste Renaud.
Molecular Cell (2014)
An interaction between DNA ligase I and proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining
David S. Levin;Wei Bai;Nina Yao;Michael O’Donnell.
Proceedings of the National Academy of Sciences of the United States of America (1997)
DNA ligases: structure, reaction mechanism, and function.
Alan E. Tomkinson;Sangeetha Vijayakumar;John M. Pascal;Tom Ellenberger.
Chemical Reviews (2006)
Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair
John B. Leppard;Zhiwan Dong;Zachary B. Mackey;Alan E. Tomkinson.
Molecular and Cellular Biology (2003)
Mycobacterial Ku and Ligase Proteins Constitute a Two-Component NHEJ Repair Machine
Marina Della;Phillip L. Palmbos;Hui Min Tseng;Louise M. Tonkin;Louise M. Tonkin.
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