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Susan P. Lees-Miller

Susan P. Lees-Miller

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
91
Citations
26910
World Ranking
2345
National Ranking
70

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2010 - Fellow of the Royal Society of Canada Academy of Science

Overview

Susan P. Lees-Miller is affiliated with the University of Calgary in Canada and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology with significant work in oncology, spectroscopy, structural biology, and pulmonary and respiratory medicine.

The scientist's research topics include DNA repair mechanisms, PARP inhibition in cancer therapy, advanced biosensing and bioanalysis techniques, CRISPR and genetic engineering, advanced electron microscopy techniques and applications, RNA research and splicing, and RNA modifications and cancer.

Notable recent publications include:

  • Structural basis of long-range to short-range synaptic transition in NHEJ, 2021, Nature
  • DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP, 2020, Science Advances
  • ATM-Deficient Cancers Provide New Opportunities for Precision Oncology, 2020, Cancers
  • Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease, 2020, Progress in Biophysics and Molecular Biology
  • Mechanism of efficient double-strand break repair by a long non-coding RNA, 2020, Nucleic Acids Research

Frequent co-authors collaborating with Susan P. Lees-Miller include:

  • Linda Lee
  • John A. Tainer
  • Ruiqiong Ye
  • David C. Schriemer
  • Dale A. Ramsden

Publication venues where this scientist has contributed multiple works include:

  • UNC Libraries
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances

Award recognition includes being named a Fellow of the Royal Society of Canada in 2010 by the Academy of Science.

Best Publications

  • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

    Katharine O Hartley;David Gell;Graeme C.M Smith;Hong Zhang

  • Repair of ionizing radiation-induced DNA double strand breaks by non-homologous end-joining

    Brandi L. Mahaney;Katheryn Meek;Susan P. Lees-Miller;Susan P. Lees-Miller

  • GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

    Stephen P. Jackson;Judy J. MacDonald;Susan Lees-Miller;Robert Tjian

  • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

    S P Lees-Miller;K Sakaguchi;S J Ullrich;E Appella

  • ATM associates with and phosphorylates p53: mapping the region of interaction

    Kum Kum Khanna.;Katherine E. Keating;Sergei Kozlov;Shaun Scott

  • Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

    Susan P. Lees-Miller;Roseline Godbout;Doug W. Chan;Michael Weinfeld

  • DNA damage-induced activation of ATM and ATM-dependent signaling pathways.

    Ebba U Kurz;Susan P Lees-Miller

  • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

    S. P. Lees-Miller;Yuh-Ru Chen;C. W. Anderson

  • Repair of DNA double strand breaks by non-homologous end joining.

    S. P. Lees-Miller;K. Meek

  • DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

    Q Song;S P Lees-Miller;S Kumar;Z Zhang

  • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

    Richard A. Woo;Kevin G. McLure;Susan P. Lees-Miller;Derrick E. Rancourt

  • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

    Qi Ding;Yeturu V. R. Reddy;Wei Wang;Timothy Woods

  • DNA‐PK autophosphorylation facilitates Artemis endonuclease activity

    Aaron A Goodarzi;Yaping Yu;Enriqueta Riballo;Pauline Douglas

  • ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation

    Shin'ichi Saito;Shin'ichi Saito;Aaron A. Goodarzi;Yuichiro Higashimoto;Yuka Noda

  • Structure of the RPA trimerization core and its role in the multistep DNA‐binding mechanism of RPA

    Elena Bochkareva;Sergey Korolev;Susan P. Lees‐Miller;Alexey Bochkarev

  • The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit.

    Doug W. Chan;Susan P. Lees-Miller

  • DNA-PK: the means to justify the ends?

    Katheryn Meek;Van Dang;Susan P. Lees-Miller

  • Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species

    Ebba U. Kurz;Pauline Douglas;Susan P. Lees-Miller

  • Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase

    Jane Parkinson;Susan P. Lees-Miller;Roger D. Everett

  • Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

    Aaron A Goodarzi;Jyoti C Jonnalagadda;Pauline Douglas;David Young

Frequent Co-Authors

John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Carl W. Anderson
Carl W. Anderson Brookhaven National Laboratory
Martin F. Lavin
Martin F. Lavin University of Queensland
Dale A. Ramsden
Dale A. Ramsden University of North Carolina at Chapel Hill
Ettore Appella
Ettore Appella National Institutes of Health
Kum Kum Khanna
Kum Kum Khanna Mater Research
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Michael Weinfeld
Michael Weinfeld University of Alberta
Tom L. Blundell
Tom L. Blundell University of Cambridge

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