Jean-Pierre de Villartay focuses on Severe combined immunodeficiency, Immunology, Genetics, Molecular biology and DNA repair. His work deals with themes such as Recombination-activating gene, Lymphocyte and Virology, which intersect with Severe combined immunodeficiency. His Immunology research is multidisciplinary, incorporating elements of Gene rearrangement, Genetic enhancement and Transplantation.
His Genetics study frequently draws connections between related disciplines such as Biochemistry. The various areas that he examines in his Molecular biology study include Gene mutation and T-cell receptor. His studies deal with areas such as Mutation and DNA replication as well as DNA repair.
His scientific interests lie mostly in DNA repair, Molecular biology, Genetics, Immunology and Mutation. His work in the fields of DNA repair, such as Non-homologous end joining, overlaps with other areas such as DNA repair protein XRCC4. The concepts of his Molecular biology study are interwoven with issues in Recombination, Immunoglobulin class switching, DCLRE1C Gene, T-cell receptor and Transcription.
Genetics connects with themes related to Cell biology in his study. His work carried out in the field of Immunology brings together such families of science as Severe combined immunodeficiency and Transplantation. His Mutation study incorporates themes from Somatic cell, Telomere, Dyskeratosis congenita, Short stature and DNA replication.
Genetics, Mutation, DNA repair, Molecular biology and Immunology are his primary areas of study. The Mutation study which covers Telomere that intersects with Helicase, Telomerase and RNA. His Non-homologous end joining study, which is part of a larger body of work in DNA repair, is frequently linked to DNA repair protein XRCC4, bridging the gap between disciplines.
His research in Non-homologous end joining intersects with topics in Ku80, RAG2 and Immunoglobulin Class Switch Recombination. His Molecular biology research includes themes of Natural killer T cell, T cell, Gene rearrangement and DNA Repair Pathway. He has included themes like Recombination-activating gene and Severe combined immunodeficiency in his VJ recombination study.
Jean-Pierre de Villartay mainly focuses on Immunology, Molecular biology, Genetics, Mutation and Gene. His Molecular biology research incorporates themes from Congenic, Non-homologous end joining, DNA repair, Telomere and Cell nucleus. His Non-homologous end joining research is multidisciplinary, relying on both Recombination-activating gene and RAG2.
His study on Eukaryotic DNA replication is often connected to GINS complex assembly as part of broader study in DNA repair. His study in the field of Transcription factor, Missense mutation, Craniosynostosis and Enhancer also crosses realms of Copy-number variation. His Mutation research integrates issues from RNA, RNA splicing, Helicase, HEK 293 cells and Dyskeratosis congenita.
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Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy
Salima Hacein-Bey-Abina;Françoise Le Deist;Frédérique Carlier;Cécile Bouneaud.
The New England Journal of Medicine (2002)
Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency
Despina Moshous;Isabelle Callebaut;Régina de Chasseval;Barbara Corneo.
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Dietke Buck;Laurent Malivert;Régina de Chasseval;Anne Barraud.
Metallo-β-lactamase fold within nucleic acids processing enzymes: the β-CASP family
Isabelle Callebaut;Despina Moshous;Jean‐Paul Mornon;Jean‐Pierre de Villartay.
Nucleic Acids Research (2002)
Severe combined immunodeficiency. A model disease for molecular immunology and therapy.
Alain Fischer;Françoise Le Deist;Salima Hacein-Bey-Abina;Isabelle André-Schmutz.
Immunological Reviews (2005)
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
Satoshi Okada;Satoshi Okada;Janet G Markle;Elissa K Deenick;Elissa K Deenick;Federico Mele.
Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis
Despina Moshous;Christophe Pannetier;Régina de Chasseval;Françoise le Deist.
Journal of Clinical Investigation (2003)
Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome.
Barbara Corneo;Despina Moshous;Tayfun Güngör;Nicolas Wulffraat.
Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
Bénédicte Neven;Bénédicte Neven;Sandrine Leroy;Sandrine Leroy;Hélène Decaluwe;Francoise Le Deist.
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV.
Dietke Buck;Despina Moshous;Régina de Chasseval;Yunmei Ma.
European Journal of Immunology (2006)
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